Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ester Caffarel-Salvador"'
Autor:
Pia Pernille Søgaard, Marianne Lind, Chatpakorn Rassemeena Christiansen, Karsten Petersson, Adam Clauss, Ester Caffarel-Salvador
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1722 (2021)
Gene therapies have conspicuously bloomed in recent years as evidenced by the increasing number of cell-, gene-, and oligo-based approved therapies. These therapies hold great promise for dermatological disorders with high unmet need, for example, ep
Externí odkaz:
https://doaj.org/article/91ea12f4b5d540a39d93d281321846ea
Autor:
Ester Caffarel-Salvador, Mary-Carmel Kearney, Rachel Mairs, Luigi Gallo, Sarah A. Stewart, Aaron J. Brady, Ryan F. Donnelly
Publikováno v:
Pharmaceutics, Vol 7, Iss 4, Pp 397-412 (2015)
Photodynamic therapy involves delivery of a photosensitising drug that is activated by light of a specific wavelength, resulting in generation of highly reactive radicals. This activated species can cause destruction of targeted cells. Application of
Externí odkaz:
https://doaj.org/article/ac350a8229d44e8982ff0a3b09dad560
Autor:
Ester Caffarel-Salvador, Aaron J Brady, Eyman Eltayib, Teng Meng, Ana Alonso-Vicente, Patricia Gonzalez-Vazquez, Barbara M Torrisi, Eva Maria Vicente-Perez, Karen Mooney, David S Jones, Steven E J Bell, Colin P McCoy, Helen O McCarthy, James C McElnay, Ryan F Donnelly
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145644 (2015)
We describe, for the first time the use of hydrogel-forming microneedle (MN) arrays for minimally-invasive extraction and quantification of drug substances and glucose from skin in vitro and in vivo. MN prepared from aqueous blends of hydrolysed poly
Externí odkaz:
https://doaj.org/article/06d0f54346524e2bbedb2a72f75da2df
Autor:
Ryan F Donnelly, Maelíosa T C McCrudden, Ahlam Zaid Alkilani, Eneko Larrañeta, Emma McAlister, Aaron J Courtenay, Mary-Carmel Kearney, Thakur Raghu Raj Singh, Helen O McCarthy, Victoria L Kett, Ester Caffarel-Salvador, Sharifa Al-Zahrani, A David Woolfson
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111547 (2014)
We describe, for the first time, hydrogel-forming microneedle arrays prepared from "super swelling" polymeric compositions. We produced a microneedle formulation with enhanced swelling capabilities from aqueous blends containing 20% w/w Gantrez S-97,
Externí odkaz:
https://doaj.org/article/339283157b53467a8c48ca0321e9ad3f
Autor:
Joy Collins, Andreas Vegge, Frantisek Hubalek, Shane McDonnell, Tadayuki Yoshitake, Fauziah R. Zakaria, Jacob Wainer, Ryan Yu Tian, Ulrik Lytt Rahbek, Soyoung Kim, Robert Langer, Giovanni Traverso, Alison Hayward, Raissa Yona, Xiaoya Lu, Ester Caffarel-Salvador, Vance Soares, Morten Revsgaard Frederiksen, Daniel Minahan, Keiko Ishida, Jessica Wong, Rebecca McManus, Xiewen Liu, Siddartha Tamang, James G. Fujimoto, Johannes Josef Fels, Sarah R. Stern, Niclas Roxhed
Publikováno v:
Science advances. 7(4)
Alternative means for drug delivery are needed to facilitate drug adherence and administration. Microneedles (MNs) have been previously investigated transdermally for drug delivery. To date, drug loading into MNs has been limited by drug solubility i
Autor:
Karsten Petersson, Adam Clauss, Chatpakorn Rassemeena Christiansen, Ester Caffarel-Salvador, Pia Pernille Søgaard, Marianne Lind
Publikováno v:
Pharmaceutics
Pharmaceutics, Vol 13, Iss 1722, p 1722 (2021)
Pharmaceutics, Vol 13, Iss 1722, p 1722 (2021)
Gene therapies have conspicuously bloomed in recent years as evidenced by the increasing number of cell-, gene-, and oligo-based approved therapies. These therapies hold great promise for dermatological disorders with high unmet need, for example, ep
Publikováno v:
PMC
Orally administered devices could enable the systemic uptake of biologic therapeutics by engineering around the physiological barriers present in the gastrointestinal (GI) tract. Such devices aim to shield cargo from degradative enzymes and increase
Autor:
Sahab Babaee, Kaitlyn Hess, Jiuyun Shi, Ameya R. Kirtane, Alison Hayward, Aniket Wahane, Robert Langer, Giovanni Traverso, Simo Pajovic, Siddartha Tamang, Joy Collins, Hormoz Mazdiyasni, Ester Caffarel-Salvador
Publikováno v:
Science Translational Medicine. 11
We hypothesized that ingested warm fluids could act as triggers for biomedical devices. We investigated heat dissipation throughout the upper gastrointestinal (GI) tract by administering warm (55°C) water to pigs and identified two zones in which th
Autor:
Ester Caffarel-Salvador, Abramson Alex G, Tomas Landh, Khang Minsoo, Yuan Gao, Robert Langer, Giovanni Traverso, Cody Cleveland, Siddartha Tamang, David Silverstein, Morten Revsgaard Frederiksen, Ulrik Lytt Rahbek, Jorrit Jeroen Water, Johannes Josef Fels, David Dellal, Niclas Roxhed, Joy Collins, Stephen T. Buckley, Anders V. Friderichsen, Rikke Kaae Kirk, Frantisek Hubalek, Andreas Vegge, Alison Hayward
Publikováno v:
PMC
Biomacromolecules have transformed our capacity to effectively treat diseases; however, their rapid degradation and poor absorption in the gastrointestinal (GI) tract generally limit their administration to parenteral routes. An oral biologic deliver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5173590c68b33410f60fe4c51c099c1
https://hdl.handle.net/1721.1/124359
https://hdl.handle.net/1721.1/124359
Autor:
Joy Collins, Ulrik Lytt Rahbek, Tadayuki Yoshitake, Robert Langer, Giovanni Traverso, Alison Hayward, Niclas Roxhed, Yuan Gao, David Dellal, Hsiang-Chieh Lee, Soyoung Kim, Ester Caffarel-Salvador, Johannes Josef Fels, Daniel Minahan, Abramson Alex G, Morten Revsgaard Frederiksen, Jacob Wainer, Siddartha Tamang, James G. Fujimoto, Vance Soares, Xiaoya Lu, Ryan Yu Tian
Publikováno v:
Nat Med
Insulin and other injectable biologic drugs have transformed the treatment of patients suffering from diabetes1,2, yet patients and healthcare providers often prefer to use and prescribe less effective orally dosed medications3-5. Compared with subcu