Increased Von Willebrand factor, decreased ADAMTS13 and thrombocytopenia in melioidosis.

Autor: Emma Birnie, Gavin C K W Koh, Ester C Löwenberg, Joost C M Meijers, Rapeephan R Maude, Nicholas P J Day, Sharon J Peacock, Tom van der Poll, W Joost Wiersinga

Publikováno v: PLoS Neglected Tropical Diseases, Vol 11, Iss 3, p e0005468 (2017)

BACKGROUND:Melioidosis, caused by bioterror treat agent Burkholderia pseudomallei, is an important cause of community-acquired Gram-negative sepsis in Southeast Asia and Northern Australia. New insights into the pathogenesis of melioidosis may help i

Externí odkaz: https://doaj.org/article/6532bcd5ea2d4bd8aab7124f8b6891fa

Increased Von Willebrand factor, decreased ADAMTS13 and thrombocytopenia in melioidosis

Autor: Gavin C. K. W. Koh, Tom van der Poll, Rapeephan R. Maude, Emma Birnie, Joost C. M. Meijers, W. Joost Wiersinga, Ester C. Löwenberg, Nicholas P. J. Day, Sharon J. Peacock

Publikováno v: PLoS Neglected Tropical Diseases, Vol 11, Iss 3, p e0005468 (2017)
PLoS neglected tropical diseases, 11(3):e0005468. Public Library of Science
PLoS Neglected Tropical Diseases

Background Melioidosis, caused by bioterror treat agent Burkholderia pseudomallei, is an important cause of community-acquired Gram-negative sepsis in Southeast Asia and Northern Australia. New insights into the pathogenesis of melioidosis may help i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa20ddea2c0544005976696f21b0314
http://europepmc.org/articles/PMC5376340?pdf=render

Acute Stress Elicited by Bungee Jumping Suppresses Human Innate Immunity

Autor: Tom van der Poll, Lu Zhou, Sander H. Diks, Goda Choi, Erik Endert, David J. van Westerloo, Karla C. S. Queiroz, Maikel P. Peppelenbosch, Alex F. de Vos, Marcel Levi, Jasper Truijen, Manuel P. F. L. Pereira, Joost C. M. Meijers, Ester C. Löwenberg

Publikováno v: Molecular medicine (Cambridge, Mass.), 17(3-4), 180-188. Feinstein Institute for Medical Research
Molecular medicine, 17(3-4), 180-188. FEINSTEIN INST MED RES

Although a relation between diminished human immunity and stress is well recognized both within the general public and the scientific literature, the molecular mechanisms by which stress alters immunity remain poorly understood, We explored a novel m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7181766b4601cd480797311e89a2dea2
https://doi.org/10.2119/molmed.2010.00204

Coagulation factor XI as a novel target for antithrombotic treatment

Autor: Ester C. Löwenberg, Brett P. Monia, Marcel Levi, Joost C. M. Meijers

Publikováno v: Journal of Thrombosis and Haemostasis. 8:2349-2357

Coagulation factor (F)XI was first described as a member of the contact pathway of coagulation. However, the 'classic' theory of the extrinsic and intrinsic pathway has been revised and FXI was found to be activated by thrombin and to play a role in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a752fc1b9b5a52c8034bc59706512009
https://doi.org/10.1111/j.1538-7836.2010.04031.x

Severe malaria is associated with a deficiency of von Willebrand factor cleaving protease, ADAMTS13

Autor: F. Nuchsongsin, Mahtabuddin Hassan, Emran Bin Yunus, Marcel Levi, Gofranul Hoque, Joost C. M. Meijers, Ester C. Löwenberg, Arjen M. Dondorp, Sophie Cohen, B.-J. van den Born, Prakaykaew Charunwatthana, Richard J. Maude

Publikováno v: Thrombosis and haemostasis, 103(1), 181-187. Schattauer GmbH

SummarySevere falciparum malaria remains a major killer in tropical countries. Central in the pathophysiology is mechanical obstruction in the micro-circulation caused by cytoadherence and sequestration of parasitized erythrocytes. However, the patho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::849658a46cb22ffe7a30117b8343f9b8
https://pubmed.ncbi.nlm.nih.gov/20062916