Abstract 3134: CCN3 is a prognostic biomarker and functional mediator of prostate cancer bone metastasis

Autor: Matthew Dankner, Veronique Ouellet, Laudine Desreumaux-Communal, Estelle Schmitt, Dru Perkins, Matthew G. Annis, Veronique Barres, Christine Caron, Anne-Marie Mes-Masson, Fred Saad, Peter M. Siegel

Publikováno v: Cancer Research. 79:3134-3134

Background: Prostate cancer commonly metastasizes to the bone, resulting in pathological fractures and poor prognosis. CCN3/NOV (Nephroblastoma overexpressed) is a secreted protein with a known role in breast cancer metastasis to bone. However, in pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb906f072b26698ca1348e6cd464e0f6
https://doi.org/10.1158/1538-7445.am2019-3134

CCN3/NOV as a functional driver and prognostic biomarker of prostate cancer bone metastasis

Autor: Anne-Marie Mes-Masson, Estelle Schmitt, Veronique Ouellet, Peter M. Siegel, Matthew Dankner, Matthew G. Annis, Laudine Desreumaux-Communal, Véronique Barrès, Fred Saad, Christine Caron, Dru Perkins

Publikováno v: Journal of Clinical Oncology. 37:182-182

182 Background: Prostate cancer commonly metastasizes to the bone, resulting in pathological fractures and poor prognosis. CCN3/NOV (Nephroblastoma overexpressed) has been implicated in promoting the formation of osteolytic prostate cancer (PC) bone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5cc601464defce1afdb2ddec01764f5e
https://doi.org/10.1200/jco.2019.37.7_suppl.182

Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2–M transition

Autor: Bernard Monsarrat, Gladys Mirey, Nathalie Theis-Febvre, Estelle Schmitt, Stéphanie Dutertre, Carine Froment, Jean-Pierre Bouché, Martine Cazales, Christine Dozier, Bernard Ducommun, Muriel Quaranta, Valerie Trabut, Claude Prigent

Publikováno v: Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2004, 117 (Pt 12), pp.2523-31. ⟨10.1242/jcs.01108⟩
Journal of Cell Science, 2004, 117 (Pt 12), pp.2523-31. ⟨10.1242/jcs.01108⟩
Journal of Cell Science 12 (117), 2523-2531. (2004)

Aurora-A protein kinase, which is the product of an oncogene, is required for the assembly of a functional mitotic apparatus and the regulation of cell ploidy. Overexpression of Aurora-A in tumour cells has been correlated with cancer susceptibility

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cff8abee3fecb95f19dbdbaac02ee3e5
https://doi.org/10.1242/jcs.01108

Bax-α promotes apoptosis induced by cancer chemotherapy and accelerates the activation of caspase 3-like cysteine proteases in p53 double mutant B lymphoma Namalwa cells

Autor: Richard Bertrand, Estelle Schmitt, Alain Steyaert, Guido Cimoli

Publikováno v: Cell Death & Differentiation. 5:506-516

Stable transfected human p53 (mt/mt) B lymphoma Namalwa variant lines showing differential expression of the Bax-alpha protein were derived under hygromycin selection. Overexpression of Bax-alpha in these variant cells accelerates cell death induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1398a33270f9b0299330cebff7ff2019
https://doi.org/10.1038/sj.cdd.4400376

Differential mitotic degradation of the CDC25B phosphatase variants

Autor: Estelle Schmitt, I Kieffer, Christine Dozier, Bernard Ducommun, Corinne Lorenzo

Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 2007, 26 (57), pp.7847-58. ⟨10.1038/sj.onc.1210596⟩

CDC25 phosphatases control cell-cycle progression by dephosphorylating and activating cyclin-dependent kinases. CDC25B, one of the three members of this family in human cells, is thought to regulate initial mitotic events. CDC25B is an unstable prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a348c488d6291e4c8372ba5375013003
https://hal.archives-ouvertes.fr/hal-00317345