Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Estelle M. N. Hamelin"'
Autor:
Stephen Martin Courtney, Suganthan Selvaratnam, Christopher John Yarnold, Paolo Tavecchia, Mirco Meniconi, Carlo Riva, Estelle M. N. Hamelin, Helen S. Boehm, Raffaella Di Lucrezia, David Willows, Paul Giles, J. Marie Bainbridge, Jörn Jungmann, Sakthi Shanmugathasan, Hervé Deboves, Giorgio Sironi, Amedeo Leonardi, Mark Brewer, Andreas Scheel
Publikováno v:
ChemistrySelect. 2:175-189
The development of selective steroidal mineralocorticoid receptor antagonists with improved pharmacological profiles over existing marketed drugs is an attractive goal. Such compounds offer potential for the treatment of hypertension, heart failure a
Autor:
John J. Barker, Saverio Minucci, Roberto Boggio, Mario Varasi, Osamu Ichihara, Thomas Hesterkamp, Annett Müller, Mark Whittaker, Stephen Martin Courtney, Mihaly Gardiner, Oliver Barker, Banu G. Phillips, Vincent Anthony Corden, Christian Aldo Georges Napoleon Montalbetti, Christopher John Yarnold, Estelle M. N. Hamelin, Fulvia Fusar, Deepti Patel, Owen Mather, Viddhata Chauhan, Robert K. Y. Cheng, Dirk Winkler, Neil Edwards, Virginie M. Falque, Richard S. Jones, Ciro Mercurio
Publikováno v:
ChemMedChem. 4:963-966
Heat shock protein 90 (Hsp90) plays a key role in stress response and protection of the cell against the effects of mutation. Herein we report the identification of an Hsp90 inhibitor identified by fragment screening using a high-concentration bioche
Autor:
William N. Draffin, Michael G. B. Drew, Laurence M. Harwood, Estelle M.-N. Hamelin, David J. Aldous, Sukanthini Thurairatnam
Publikováno v:
Synthesis. :3271-3278
We report herein, the first generation of unsymmetrical ketone-derived chiral stabilized azomethine ylides. Intrairiolecular and intermolecular cycloaddition strategies have been utilized to synthesize both an enantiornerically pure bicyclic proline
Autor:
Michael G. B. Drew, Archie B. Jahans, Sukanthini Thurairatnam, Laurence M. Harwood, Estelle M.-N. Hamelin, David J. Aldous
Publikováno v:
Synlett. 2001:1836-1840
Publikováno v:
Synlett. 2001:1841-1842