Výsledky vyhledávání - "Estelle Lecluze"

Akademický článek

RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2

Autor: Barbara Nicol, Sara A. Grimm, Frédéric Chalmel, Estelle Lecluze, Maëlle Pannetier, Eric Pailhoux, Elodie Dupin-De-Beyssat, Yann Guiguen, Blanche Capel, Humphrey H.-C. Yao

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Proper ovarian differentiation requires RUNX1. Here, the authors show that double knockout of Runx1/Foxl2 results in masculinization of fetal ovaries, and that RUNX1 and FOXL2 jointly occupy common chromatin regions to maintain pre-granulosa cell ide

Externí odkaz: https://doaj.org/article/70611c2bdf5d4776a09548dc9ccd8240

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Association analyses of predicted loss-of-function variants prioritized 15 genes as blood pressure regulators

Autor: Estelle Lecluze, Guillaume Lettre

BackgroundHypertension, clinically defined by elevated blood pressure (BP), is an important cause of mortality and morbidity worldwide. Many risk factors for hypertension are known, including a positive family history, which suggests that genetics co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81d8537f649591a733e419f5db5ddc1a
https://doi.org/10.1101/2023.03.13.23287209

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Dynamics of the transcriptional landscape during human fetal testis and ovary development

Autor: Vincent Lavoué, Millissia Ben Maamar, Frédéric Chalmel, Sabrina Leverrier-Penna, Séverine Mazaud-Guittot, Antoine Rolland, Estelle Lecluze, Bertrand Evrard, Paul Fowler, Bernard Jégou, Panagiotis Filis, Isabelle Coiffec

Publikováno v: Human Reproduction
Human Reproduction, 2020, 35 (5), pp.1099-1119. ⟨10.1093/humrep/deaa041⟩
Human Reproduction, Oxford University Press (OUP), 2020, 35 (5), pp.1099-1119. ⟨10.1093/humrep/deaa041⟩

STUDY QUESTION Which transcriptional program triggers sex differentiation in bipotential gonads and downstream cellular events governing fetal testis and ovary development in humans? SUMMARY ANSWER The characterization of a dynamically regulated prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eff80fcd5565d46c242ace9869424ae
https://doi.org/10.1093/humrep/deaa041

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Hypoxia and ERα Transcriptional Crosstalk Is Associated with Endocrine Resistance in Breast Cancer

Autor: Charly Jehanno, Pascale Le Goff, Denis Habauzit, Yann Le Page, Sylvain Lecomte, Estelle Lecluze, Frédéric Percevault, Stéphane Avner, Raphaël Métivier, Denis Michel, Gilles Flouriot

Publikováno v: Cancers
Cancers, 2022, 14 (19), pp.4934. ⟨10.3390/cancers14194934⟩
Cancers; Volume 14; Issue 19; Pages: 4934

International audience; Estrogen receptor-alpha (ER alpha) is the driving transcription factor in 70% of breast cancers and its activity is associated with hormone dependent tumor cell proliferation and survival. Given the recurrence of hormone resis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e34234f2e2cbd379b40e4e31817de4d
https://doi.org/10.3390/cancers14194934

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RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2

Autor: Blanche Capel, Yann Guiguen, Eric Pailhoux, Maëlle Pannetier, Humphrey H.-C. Yao, Frédéric Chalmel, Barbara Nicol, Elodie Dupin-De-Beyssat, Sara A. Grimm, Estelle Lecluze

Publikováno v: Nature Communications
Nature Communications, 2019, 10:5116 (1), pp.1-14. ⟨10.1038/s41467-019-13060-1⟩
Nature Communications, Nature Publishing Group, 2019, 10:5116 (1), pp.1-14. ⟨10.1038/s41467-019-13060-1⟩
Nature Communications (10), 1-14. (2019)
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.5116. ⟨10.1038/s41467-019-13060-1⟩
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Sex determination of the gonads begins with fate specification of gonadal supporting cells into either ovarian pre-granulosa cells or testicular Sertoli cells. This fate specification hinges on a balance of transcriptional control. Here we report tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5102796c42741e677f88979507a843b7
http://europepmc.org/articles/PMC6848188

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The ReproGenomics Viewer: a multi-omics and cross-species resource compatible with single-cell studies for the reproductive science community

Autor: Nathan Alary, Isabelle Stévant, Aurélie Lardenois, Thomas A Darde, Estelle Lecluze, Frank Tüttelmann, Frédéric Chalmel, Bernard Jégou, Antoine Rolland, Serge Nef, Olivier Collin

Publikováno v: Bioinformatics
Bioinformatics, 2019, 35 (17), pp.3133-3139. ⟨10.1093/bioinformatics/btz047⟩
Bioinformatics (2019)
Bioinformatics, Oxford University Press (OUP), 2019, 35 (17), pp.3133-3139. ⟨10.1093/bioinformatics/btz047⟩

MotivationRecent advances in transcriptomics have enabled unprecedented insight into gene expression analysis at a single-cell resolution. While it is anticipated that the number of publications based on such technologies will increase in the next de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a886257e1397d40bf60d96b6e24b057
https://univ-rennes.hal.science/hal-02015545

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RUNX1 safeguards the identity of the fetal ovary through an interplay with FOXL2

Autor: Blanche Capel, Yann Guiguen, Eric Pailhoux, Elodie Dupin-De-Beyssat, Sara A. Grimm, Humphrey H.-C. Yao, Barbara Nicol, Frédéric Chalmel, Estelle Lecluze, Maëlle Pannetier

Sex determination of the gonads begins with fate specification of gonadal supporting cells into either ovarian granulosa cells or testicular Sertoli cells. This process of fate specification hinges on a balance of transcriptional control. We discover

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d601a0f029127b79d9ea8f88006583d1
https://hal.inrae.fr/hal-02790582

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New transcriptomic tools to understand testis development and functions

Autor: Estelle Lecluze, Frédéric Chalmel, Bernard Jégou, Antoine Rolland

Publikováno v: Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology, Elsevier, 2018, 468, pp.47-59. ⟨10.1016/j.mce.2018.02.019⟩
Molecular and Cellular Endocrinology, 2018, 468, pp.47-59. ⟨10.1016/j.mce.2018.02.019⟩

International audience; The testis plays a central role in the male reproductive system - secreting several hormones including male steroids and producing male gametes. A complex and coordinated molecular program is required for the proper differenti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5058405d72979043b5f10d0d6516b02
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01864339

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