Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Estelle J.A. Suys"'
From influenza to COVID-19: Lipid nanoparticle mRNA vaccines at the frontiers of infectious diseases
Autor:
Thomas P. Davis, Adam K. Wheatley, Stephen J. Kent, Colin W. Pouton, Estelle J.A. Suys, Natalie L. Trevaskis, Azizah Algarni, Emily H. Pilkington, Nghia P. Truong, Hareth Al-Wassiti, Danijela Zukancic
Publikováno v:
Acta Biomaterialia
Vaccination represents the best line of defense against infectious diseases and is crucial in curtailing pandemic spread of emerging pathogens to which a population has limited immunity. In recent years, mRNA vaccines have been proposed as the new fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b948c75d8f4d79051e9c052b6d610818
https://doi.org/10.1016/j.actbio.2021.06.023
https://doi.org/10.1016/j.actbio.2021.06.023
Publikováno v:
Molecular Pharmaceutics. 18:1768-1778
The aim of this study was to evaluate the effect of lipid digestion on the permeability and absorption of orally administered saquinavir (SQV), a biopharmaceutics classification system (BCS) class IV drug, in different lipid-based formulations. Three
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::080d9f6377d650d0fe5d3908dcae8ef6
https://doi.org/10.1021/acs.molpharmaceut.1c00015
https://doi.org/10.1021/acs.molpharmaceut.1c00015
Autor:
Cameron J. Nowell, Daniel H.S. Brundel, Lisa M. Kaminskas, Gracia Gracia, Orlagh M. Feeney, Christopher J.H. Porter, Michelle M. McIntosh, David W. Kang, Estelle J.A. Suys
Publikováno v:
Nanomedicine. 16:275-292
Aim: Delivery of nanoparticles (NPs) to tumors can be impeded by high levels of hyaluronan (HA) in the stroma. Enzymatic depolymerization of HA with PEGylated hyaluronidase (PEGPH20) improves the delivery of antibodies to tumors. However, it is unkno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d58a79faf1ed4ce52d5c4edfebf9ae
https://doi.org/10.2217/nnm-2020-0433
https://doi.org/10.2217/nnm-2020-0433
Autor:
Thai Thanh Hoang Thi, Estelle J.A. Suys, Jung Seok Lee, Ki Dong Park, Dai Hai Nguyen, Nghia P. Truong
Publikováno v:
Vaccines
Vaccines, Vol 9, Iss 359, p 359 (2021)
Vaccines, Vol 9, Iss 359, p 359 (2021)
COVID-19 vaccines have been developed with unprecedented speed which would not have been possible without decades of fundamental research on delivery nanotechnology. Lipid-based nanoparticles have played a pivotal role in the successes of COVID-19 va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::333e0d229ac846445e268f8451ae329d
https://pubmed.ncbi.nlm.nih.gov/33918072
https://pubmed.ncbi.nlm.nih.gov/33918072
Autor:
Azizah Algarni, Emily H. Pilkington, Hareth Al-Wassiti, Nghia P. Truong, Danijela Zukancic, Estelle J.A. Suys
Publikováno v:
Pharmaceutics, Vol 12, Iss 1068, p 1068 (2020)
Pharmaceutics
Volume 12
Issue 11
Pharmaceutics
Volume 12
Issue 11
Targeted delivery of nucleic acids to lymph nodes is critical for the development of effective vaccines and immunotherapies. However, it remains challenging to achieve selective lymph node delivery. Current gene delivery systems target mainly to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d806e7570470acd2b43fa6e6371451
https://www.mdpi.com/1999-4923/12/11/1068
https://www.mdpi.com/1999-4923/12/11/1068
Autor:
Daniel H.S. Brundel, Christopher J.H. Porter, Colin W. Pouton, David K. Chalmers, Estelle J.A. Suys
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 331
Drug absorption from lipid-based formulations (LBFs) in the gastrointestinal (GI) tract is the result of a series of processes, including formulation dispersion, interaction with biliary and pancreatic secretions, drug solubilisation and supersaturat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c83799ef04a106c8ea4940b4d150d457
https://pubmed.ncbi.nlm.nih.gov/33450318
https://pubmed.ncbi.nlm.nih.gov/33450318
Autor:
Cameron J. Nowell, Anna C. Pham, David K. Chalmers, Christopher J.H. Porter, Hassan Benameur, Estelle J.A. Suys, Andrew J. Clulow, Dallas B. Warren, Colin W. Pouton
Publikováno v:
Journal of Pharmaceutical Sciences. 108:193-204
Polyethoxylated, nonionic surfactants are important constituents of many drug formulations, including lipid-based formulations. In an effort to better understand the behavior of formulation excipients at the molecular level, we have developed molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07509fadd096b3dfa2dd1295877eb1f0
https://doi.org/10.1016/j.xphs.2018.11.028
https://doi.org/10.1016/j.xphs.2018.11.028
Publikováno v:
Molecular Pharmaceutics. 15:2355-2371
The ability of lipid-based formulations (LBFs) to increase the solubilization, and prolong the supersaturation, of poorly water-soluble drugs (PWSDs) in the gastrointestinal (GI) fluids has generated significant interest in the past decade. One mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e667c5eb80196217b41dd48cb0a32c8
https://doi.org/10.1021/acs.molpharmaceut.8b00206
https://doi.org/10.1021/acs.molpharmaceut.8b00206
Autor:
Estelle J.A. Suys, Hassan Benameur, Colin W. Pouton, Christopher J.H. Porter, Dallas B. Warren, David K. Chalmers
Publikováno v:
Molecular pharmaceutics. 14(11)
In this study, we use molecular dynamics (MD) and experimental techniques (nephelometry and dynamic light scattering) to investigate the influence of cholesterol content and pH on the colloidal structures that form in the gastrointestinal (GI) tract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad86cd04ae04fb6af239ea83c949c59
https://pubmed.ncbi.nlm.nih.gov/28980815
https://pubmed.ncbi.nlm.nih.gov/28980815