PDIA, an Iminosugar Compound with a Wide Biofilm Inhibitory Spectrum Covering Both Gram-Positive and Gram-Negative Human Bacterial Pathogens

Autor: Łucja Kozień, Estelle Gallienne, Olivier Martin, Sophie Front, Magdalena Strus, Piotr Heczko

Publikováno v: Microorganisms, Vol 10, Iss 6, p 1222 (2022)

Many difficult-to-treat human infections related to catheters and other indwelling devices are caused by bacteria residing in biofilms. One of the key properties of microorganisms residing in a biofilm is decreased susceptibility towards antimicrobia

Externí odkaz: https://doaj.org/article/604854bb88dd41ec881cac6bfecd1c3d

Hydrozirconation/bromination, followed by a Michaelis-Arbuzov reaction, as a convenient approach towards polyfunctional glycosylphosphonates

Autor: Kévin Mébarki, Floriane Heis, Thomas Lecour, Véronique Chassagne, Estelle Gallienne, Marine Gavel, Alexandra Le Foll, Olivier R. Martin, Antoine Joosten

Publikováno v: Carbohydrate Research
Carbohydrate Research, Elsevier, 2020, ⟨10.1016/j.carres.2020.108228⟩
Carbohydrate Research, 2020, ⟨10.1016/j.carres.2020.108228⟩

International audience; In this note, an hydrozirconation/bromination/Michaelis-Arbuzov sequence was developped to introduce a trimethylene phosphonate unit on ketopyranosides. Performed on polyfunctional substrates bearing orthogonal protecting grou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148a7abe6b272deffdc87ae04eb32da5
https://hal-normandie-univ.archives-ouvertes.fr/hal-03151446

4-epi-Isofagomine derivatives as pharmacological chaperones for the treatment of lysosomal diseases linked to β-galactosidase mutations: Improved synthesis and biological investigations

Autor: Tim Wood, Sofia Almeida, Julie Charollais-Thoenig, Sophie Front, Estelle Gallienne, Céline Marmy, Vincent Pilloud, Olivier R. Martin, Vincent Zoete, Stéphane Demotz, Roger Marti

Publikováno v: Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, 2018, 26 (20), pp.5462-5469. ⟨10.1016/j.bmc.2018.09.023⟩
Bioorganic and Medicinal Chemistry, Elsevier, 2018, 26 (20), pp.5462-5469. ⟨10.1016/j.bmc.2018.09.023⟩

International audience; (5aR)-5a-C-pentyl-4-epi-isofagomine 1 is a powerful inhibitor of lysosomal β-galactosidase and a remarkable chaperone for mutations associated with GM1-gangliosidosis and Morquio disease type B. We report herein an improved s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50af9c886c0e8bd662aae5364f47b51
https://univ-orleans.hal.science/hal-02179720

Stereoselective synthesis of 1-C-alkyl iminogalactitol derivatives, potential chaperones for galactosidase-linked LSDs: a real challenge

Autor: Anna Biela-Banaś, Estelle Gallienne, Olivier R. Martin, Sophie Front

Publikováno v: Tetrahedron Letters. 55:838-841

1-C-Alkyl iminogalactitol derivatives are highly desirable target compounds as potential pharmacological chaperones for the treatment of galactosidase-linked lysosomal storage disorders (LSDs). The synthesis of such compounds from d-galactose by a C-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3044ec634fef44165fdda9912fda20e
https://doi.org/10.1016/j.tetlet.2013.12.024

An improved methodology for the synthesis of 1-C-allyl imino-d-xylitol and -l-arabinitol and their rapid functionalization

Autor: Olivier R. Martin, Estelle Gallienne, Anna Biela, Jadwiga Frelek, Farah Oulaïdi, Marcin Górecki

Publikováno v: Tetrahedron. 69:3348-3354

As part of our research program dedicated to the design and synthesis of new iminosugars as pharmacological chaperones for the treatment of lysosomal storage disorders, we developed a rapid and efficient methodology for the access to functionalized a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83e997db7242f3050a71888603f6c1a4
https://doi.org/10.1016/j.tet.2012.12.082