Výsledky vyhledávání - "Estelle Dransart"

Akademický článek

Exploration into Galectin-3 Driven Endocytosis and Lattices

Autor: Massiullah Shafaq-Zadah, Estelle Dransart, Satish Kailasam Mani, Julio Lopes Sampaio, Lydia Bouidghaghen, Ulf J. Nilsson, Hakon Leffler, Ludger Johannes

Publikováno v: Biomolecules, Vol 14, Iss 9, p 1169 (2024)

Essentially all plasma membrane proteins are glycosylated, and their activity is regulated by tuning their cell surface dynamics. This is achieved by glycan-binding proteins of the galectin family that either retain glycoproteins within lattices or d

Externí odkaz: https://doaj.org/article/5cd986dc895f41daa399c4b735f43adf

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Akademický článek

Glycolipid-dependent and lectin-driven transcytosis in mouse enterocytes

Autor: Alena Ivashenka, Christian Wunder, Valerie Chambon, Roger Sandhoff, Richard Jennemann, Estelle Dransart, Katrina Podsypanina, Bérangère Lombard, Damarys Loew, Christophe Lamaze, Francoise Poirier, Hermann-Josef Gröne, Ludger Johannes, Massiullah Shafaq-Zadah

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)

Ivashenka et al. report that galectin-3 (Gal3) binding to lactotransferrin drives its transcytosis in enterocytes. Such trafficking is Gal3- and glycosphingolipid-dependent, and Gal3 is found in clathrin-independent carriers. These findings suggest t

Externí odkaz: https://doaj.org/article/ddd280be10104d1db4c00ab5b1dd138b

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Akademický článek

CXCR6 deficiency impairs cancer vaccine efficacy and CD8+ resident memory T-cell recruitment in head and neck and lung tumors

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)

Background Resident memory T lymphocytes (TRM) are located in tissues and play an important role in immunosurveillance against tumors. The presence of TRM prior to treatment or their induction is associated to the response to anti-Programmed cell dea

Externí odkaz: https://doaj.org/article/7396a1c31d234ef2b59347b1a9805e52

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Akademický článek

Local IFNα enhances the anti-tumoral efficacy of systemic anti-PD1 to prevent tumor relapse

Autor: Maxime Thoreau, Fabienne Regnier, Ludger Johannes, Estelle Dransart, Alain Trautmann, Nadege Bercovici, Marion v Guerin, Lene Vimeux, Matthieu Benard, Hweixian L Penny

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

Background Tumor relapse constitutes a major challenge for anti-tumoral treatments, including immunotherapies. Indeed, most cancer-related deaths occur during the tumor relapse phase.Methods We designed a mouse model of tumor relapse in which mice tr

Externí odkaz: https://doaj.org/article/eb416a1a1ddb4c35877b667537985dcb

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Akademický článek

Induction of resident memory T cells enhances the efficacy of cancer vaccine

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

Resident memory T cells (Trm) are memory T cells that remain in tissue. Here, the authors show that induction of Trm cells is required for control of tumour growth following mucosal vaccination in mice bearing head and neck cancer and that Trm cells

Externí odkaz: https://doaj.org/article/2c09610a4b334c25a37a0973fab8481f

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Akademický článek

Tumor Delivery of Ultrasound Contrast Agents Using Shiga Toxin B Subunit

Autor: Olivier Couture, Estelle Dransart, Sabrina Dehay, Fariba Nemati, Didier Decaudin, Ludger Johannes, Mickael Tanter

Publikováno v: Molecular Imaging, Vol 10 (2011)

The present study demonstrates the targeting of ultrasound contrast agents to human xenograft tumors by exploiting the overexpression of the glycolipid Gb3 in neovasculature. To this end, microbubbles were functionalized with a natural Gb3 ligand, th

Externí odkaz: https://doaj.org/article/aa4fa1b8dba34e69bc45c1d9b8246b9e

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Akademický článek

In Vivo Tumor Targeting by the B-Subunit of Shiga Toxin

Autor: Thomas Viel, Estelle Dransart, Fariba Nemati, Emilie Henry, Benoit Thézé, Didier Decaudin, Daniel Lewandowski, Raphael Boisgard, Ludger Johannes, Bertrand Tavitian

Publikováno v: Molecular Imaging, Vol 7 (2008)

Delivery of drugs to the appropriate target cells would improve efficacy and reduce potential side effects. The nontoxic B-subunit of the intestinal pathogen-produced Shiga toxin (STxB) binds specifically to the glycosphingolipid Gb 3 , overex-presse

Externí odkaz: https://doaj.org/article/3bd322884120473382681be82d373418

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