Biopterin metabolism and eNOS expression during hypoxic pulmonary hypertension in mice.

Autor: Mathilde Dubois, Estelle Delannoy, Lucie Duluc, Ellen Closs, Huige Li, Christian Toussaint, Alain-Pierre Gadeau, Axel Gödecke, Véronique Freund-Michel, Arnaud Courtois, Roger Marthan, Jean-Pierre Savineau, Bernard Muller

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e82594 (2013)

Tetrahydrobiopterin (BH4), which fosters the formation of and stabilizes endothelial NO synthase (eNOS) as an active dimer, tightly regulates eNOS coupling / uncoupling. Moreover, studies conducted in genetically-modified models demonstrate that BH4

Externí odkaz: https://doaj.org/article/daf2ff7938b441cca853d75689a580ad

Hypoxia-induced hyperreactivity of pulmonary arteries: role of cyclooxygenase-2, isoprostanes, and thromboxane receptors

Autor: Bernard Muller, Arnaud Courtois, Véronique Leblais, Véronique Freund-Michel, Estelle Delannoy, Roger Marthan

Publikováno v: Cardiovascular Research. 85:582-592

Aims This study investigates the role of the cyclooxygenase (COX)/prostanoid pathway in chronic hypoxia-induced hyperreactivity of pulmonary arteries. Methods and results Pulmonary arteries were removed from normoxic or hypoxic (0.5 atm for 21 days)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::937b95c2bc128535d85ec1a6cb603b45
https://doi.org/10.1093/cvr/cvp292

Biopterin metabolism and eNOS expression during hypoxic pulmonary hypertension in mice

Autor: Lucie Duluc, Jean-Pierre Savineau, Axel Gödecke, Ellen I. Closs, Alain-Pierre Gadeau, Arnaud Courtois, Véronique Freund-Michel, Bernard Muller, Huige Li, Mathilde Dubois, Roger Marthan, Christian Toussaint, Estelle Delannoy

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e82594 (2013)
PLoS ONE
PLoS ONE, Public Library of Science, 2013, 8 (11), pp.e82594. ⟨10.1371/journal.pone.0082594⟩

International audience; Tetrahydrobiopterin (BH$_4$), which fosters the formation of and stabilizes endothelial NO synthase (eNOS) as an active dimer, tightly regulates eNOS coupling / uncoupling. Moreover, studies conducted in genetically-modified m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406ae64c464c76e627b5e2fdcd0fe2a0
http://europepmc.org/articles/PMC3842263?pdf=render

Impairment of NO-dependent relaxation in intralobar pulmonary arteries: comparison of urban particulate matter and manufactured nanoparticles

Autor: Hugues Begueret, Yannick Ladeiro, Marie Annick Billon Galland, Isabelle Baudrimont, Arnaud Courtois, Estelle Delannoy, Bernard Muller, Francelyne Marano, Véronique Leblais, Patrick Brochard, Pascal Andujar, Roger Marthan

Publikováno v: Environmental Health Perspectives
Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2008, 116 (10), pp.1294-9. ⟨10.1289/ehp.11021⟩

International audience; BACKGROUND AND OBJECTIVES: Because pulmonary circulation is the primary vascular target of inhaled particulate matter (PM), and nitric oxide is a major vasculoprotective agent, in this study we investigated the effect of vario

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c638a81a27979cdda55080e78310de
https://www.hal.inserm.fr/inserm-00339267/document

P113. Potential role of uncoupled endothelial NO-synthase in alterations of vasomotor responses of pulmonary arteries induced by chronic hypoxia

Autor: Bernard Muller, Alain P. Gadeau, Arnaud Courtois, Claude Desgranges, Véronique Leblais, Estelle Delannoy, Roger Marthan

Publikováno v: Nitric Oxide. 19:70

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::468493fd46e1b98576db4af85a1f051f
https://doi.org/10.1016/j.niox.2008.06.211