Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Estela Jacinto"'
Autor:
Guy Werlen, Mei-Ling Li, Luca Tottone, Victoria da Silva-Diz, Xiaoyang Su, Daniel Herranz, Estela Jacinto
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Although T cell commitment to specific lineages coincides with the rearrangement of T cell receptor loci, it remains unclear whether metabolism also influences this process. Here, authors show that de novo hexosamine biosynthesis promotes αβ T cell
Externí odkaz:
https://doaj.org/article/03bd53820a824ec5ad20fed9b1e12f4c
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
It has been reported that the mechanistic target of rapamycin (mTOR) pathway is involved in cerebral ischemia–reperfusion injury. One of the important pathological changes during reperfusion after cerebral ischemia is disruption of blood–brain ba
Externí odkaz:
https://doaj.org/article/2cb569ace4514c299c6de4ab0f1ec6a4
Autor:
Federico La Manna, Marta De Menna, Nikhil Patel, Sofia Karkampouna, Maria Rosaria De Filippo, Irena Klima, Peter Kloen, Lijkele Beimers, George N. Thalmann, Rob C. M. Pelger, Estela Jacinto, Marianna Kruithof-de Julio
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Externí odkaz:
https://doaj.org/article/f30d7eb96bd947879fea5fbee5c6c889
Autor:
Federico La Manna, Marta De Menna, Nikhil Patel, Sofia Karkampouna, Maria De Filippo, Irena Klima, Peter Kloen, Lijkele Beimers, George N. Thalmann, Rob C. M. Pelger, Estela Jacinto, Marianna Kruithof-de Julio
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Bone metastasis is the leading cause of prostate cancer (PCa) mortality, frequently marking the progression to castration-resistant PCa. Dysregulation of the androgen receptor pathway is a common feature of castration-resistant PCa, frequently appear
Externí odkaz:
https://doaj.org/article/914236bb387547269f378db2b2a702de
Autor:
Po-Chien Chou, Swati Rajput, Xiaoyun Zhao, Chadni Patel, Danielle Albaciete, Won Jun Oh, Heineken Queen Daguplo, Nikhil Patel, Bing Su, Guy Werlen, Estela Jacinto
Publikováno v:
Cells, Vol 9, Iss 7, p 1567 (2020)
Cells adjust to nutrient fluctuations to restore metabolic homeostasis. The mechanistic target of rapamycin (mTOR) complex 2 responds to nutrient levels and growth signals to phosphorylate protein kinases belonging to the AGC (Protein Kinases A,G,C)
Externí odkaz:
https://doaj.org/article/c37c3acda08744d6a7442b784ab14874
Publikováno v:
Physiol Rev
Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and proliferation. The uptake of nutrients from the environment and their intracellular metabolism is a highly controlled process that involves cross talk between growt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31893371b43ba22238b11eb62ca49245
https://doi.org/10.1152/physrev.00026.2020
https://doi.org/10.1152/physrev.00026.2020
Publikováno v:
Genes. 14:933
The hexosamine biosynthesis pathway (HBP) produces uridine diphosphate-N-acetyl glucosamine, UDP-GlcNAc, which is a key metabolite that is used for N- or O-linked glycosylation, a co- or post-translational modification, respectively, that modulates p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75331498cfdac8ca3329e5f801eda7ee
https://doi.org/10.3390/genes14040933
https://doi.org/10.3390/genes14040933
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a51e83437c2d24439ad8989eef41f9a
https://doi.org/10.1096/fasebj.2022.36.s1.0r396
https://doi.org/10.1096/fasebj.2022.36.s1.0r396
Autor:
Huimei Lu, Caiyong Ye, Dimitri G. Pestov, Bochao Liu, Zhiyuan Shen, Jingmei Liu, Arnold B. Rabson, Estela Jacinto
Publikováno v:
Nucleic Acids Research
Ribosome biogenesis is a fundamental process required for cell proliferation. Although evolutionally conserved, the mammalian ribosome assembly system is more complex than in yeasts. BCCIP was originally identified as a BRCA2 and p21 interacting prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f22adc865562a39fe81688fe93c656a
http://europepmc.org/articles/PMC7736804
http://europepmc.org/articles/PMC7736804
Autor:
Mei-Ling Li, Aparna Ragupathi, Nikhil Patel, Tatiana Hernandez, Jedrick Magsino, Guy Werlen, Gary Brewer, Estela Jacinto
Publikováno v:
Journal of Biological Chemistry. 298:102437
Mammalian target of rapamycin (mTOR), which is part of mTOR complex 1 (mTORC1) and mTORC2, controls cellular metabolism in response to levels of nutrients and other growth signals. A hallmark of mTORC2 activation is the phosphorylation of Akt, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d66d84e854a0b6a900dd86e0afd7850
https://doi.org/10.1016/j.jbc.2022.102437
https://doi.org/10.1016/j.jbc.2022.102437