Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Estela E, Medrano"'
Autor:
Danielle R. Martinez, Hunter W. Richards, Qiushi Lin, Carlos A. Torres-Cabala, Victor G. Prieto, Jonathan L. Curry, Estela E. Medrano
Publikováno v:
Journal of Skin Cancer, Vol 2012 (2012)
The current study characterizes the mitosis-associated histone dual modification on the core of histone H3: trimethylation of histone H3 lysine 79 and simultaneous phosphorylation of H3 threonine 80 (H3K79me3T80ph). Through the use of protein and mic
Externí odkaz:
https://doaj.org/article/e398d6814f7349b1b8552c96ca0218e2
Autor:
Qiushi Lin, Estela E. Medrano, Danielle R. Martinez, Carlos A. Torres-Cabala, Victor G. Prieto, Hunter W. Richards, Jonathan L. Curry
Publikováno v:
Journal of Skin Cancer, Vol 2012 (2012)
Journal of Skin Cancer
Journal of Skin Cancer
The current study characterizes the mitosis-associated histone dual modification on the core of histone H3: trimethylation of histone H3 lysine 79 and simultaneous phosphorylation of H3 threonine 80 (H3K79me3T80ph). Through the use of protein and mic
Publikováno v:
Hepatology. 54:989-998
Age declines liver functions, leading to the development of age-associated diseases. A member of the sirtuins family, SIRT1, is involved in the control of glucose homeostasis and fat metabolism. Because aging livers have alterations in glucose and fa
Publikováno v:
Cell Cycle. 9:1684-1689
The transcriptional co-regulator SKI is a potent inhibitor of TGFbeta-growth inhibitory signals. SKI binds to receptor-activated Smads in the nucleus, forming repressor complexes containing HDACs, mSin3, NCoR, and other protein partners. Alternativel
Publikováno v:
Experimental Gerontology. 45:279-285
HDAC1 is a member of the class I of histone deacetylases that also includes HDAC2, −3 and −8. Although HDAC1 has been mostly studied in the context of cancer, recent evidence strongly suggests that it plays critical roles in cellular senescence,
Autor:
Raymond L. Barnhill, Glenn Merlino, Jeffrey A. Sosman, T. M. Landi, F. S. Hodi, Estela E. Medrano, David E. Fisher, Boris C. Bastian, M. Herlyn
Publikováno v:
Pigment Cell & Melanoma Research. 23:14-26
The 2009 International Melanoma Congress sponsored by the Society for Melanoma Research brought together a large collection of laboratory researchers, students, and clinicians. Presentations were made in numerous areas spanning biological analyses to
Autor:
Dennis R. Roop, Ed Stavnezer, Jon A. Reed, Shunsuke Ishii, Koichi Matsuzaki, Dahu Chen, Thomas J. Hornyak, Tao Fan, Estela E. Medrano, Qiushi Lin, Nikolai A. Timchenko, Neil F. Box
Publikováno v:
Pigment Cell Melanoma Res
The SKI protein represses the TGF-beta tumor suppressor pathway by associating with the Smad transcription factors. SKI is upregulated in human malignant melanoma tumors in a disease-progression manner and its overexpression promotes proliferation an
Publikováno v:
Journal of Cutaneous Pathology. 36:197-205
Background The p27(KIP1) and p57(KIP2) proteins belong to the CIP/KIP family of cyclin-dependent kinase inhibitors involved in the growth arrest and cellular senescence. High levels of p27(KIP1) unexpectedly have been detected in invasive malignant m
Autor:
Hunter W. Richards, Estela E. Medrano
Publikováno v:
Pigment Cell & Melanoma Research. 22:14-29
Melanoma is a highly heterogeneous cancer that comes in different flavors (lentigo maligna melanoma, superficial spreading melanoma, nodular melanoma, acral lentiginous/mucosal melanoma and other less common subtypes including malignant cellular blue
Autor:
Lubov Timchenko, Estela E. Medrano, Guo Li Wang, Xiurong Shi, Nikolai A. Timchenko, Elizabeth Salisbury
Publikováno v:
Journal of Biological Chemistry. 283:26179-26187
HDAC1 (histone deacetylase 1) regulates a number of biological processes in cells. Our previous studies revealed that HDAC1 inhibits proliferation of the livers in old mice. We have surprisingly observed that HDAC1 is also increased in young livers p