Constrained peptides mimic a viral suppressor of RNA silencing

Autor: Arne Kuepper, Niall M McLoughlin, Saskia Neubacher, Alejandro Yeste-Vázquez, Estel Collado Camps, Chandran Nithin, Sunandan Mukherjee, Lucas Bethge, Janusz M Bujnicki, Roland Brock, Stefan Heinrichs, Tom N Grossmann

Publikováno v: Nucleic acids research, 49(22), 12622-12633. Oxford University Press
Nucleic Acids Research, 49, 22, pp. 12622-12633
Nucleic Acids Research, 49, 12622-12633
Nucleic Acids Research
Kuepper, A, McLoughlin, N M, Neubacher, S, Yeste-Vázquez, A, Collado Camps, E, Nithin, C, Mukherjee, S, Bethge, L, Bujnicki, J M, Brock, R, Heinrichs, S & Grossmann, T N 2021, ' Constrained peptides mimic a viral suppressor of RNA silencing ', Nucleic acids research, vol. 49, no. 22, pp. 12622-12633 . https://doi.org/10.1093/nar/gkab1149

The design of high-affinity, RNA-binding ligands has proven very challenging. This is due to the unique structural properties of RNA, often characterized by polar surfaces and high flexibility. In addition, the frequent lack of well-defined binding p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b39330069ff43b52fbaa43e7f2fd0706
https://doi.org/10.1093/nar/gkab1149

Site-Specific Dual-Labeling of a VHH with a Chelator and a Photosensitizer for Nuclear Imaging and Targeted Photodynamic Therapy of EGFR-Positive Tumors

Autor: Franck Denat, Martin Gotthardt, Emma Renard, Estel Collado Camps, Sanne A. M. van Lith, Annemarie Kip, Coline Canovas, Mark Rijpkema, Victor Goncalves

Publikováno v: Cancers
Cancers, MDPI, 2021, 13 (3), pp.428. ⟨10.3390/cancers13030428⟩
Cancers, 13
Cancers, 13, 3
Cancers; Volume 13; Issue 3; Pages: 428
Cancers, Vol 13, Iss 428, p 428 (2021)

Simple Summary Variable domains of heavy chain only antibodies are small proteins that can be used for tumor imaging and therapy upon conjugation of functional groups. As frequently used random conjugation techniques can decrease binding to the targe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7dee18e3a2f987aa8556ea09534139
https://hdl.handle.net/2066/230616

Metabolic sialic acid blockade lowers the activation threshold of moDCs for TLR stimulation

Autor: Torben Heise, Barbara M. Schulte, Thomas J. Boltje, Estel Collado-Camps, Gosse J. Adema, Esther D. Kers-Rebel, Jonas Nørskov Søndergaard, Martijn H. den Brok, Christian Büll

Publikováno v: Immunology and Cell Biology, 95, 4, pp. 408-415
Immunology and Cell Biology, 95, 408-415

Contains fulltext : 177820.pdf (Publisher’s version ) (Closed access) Sialic acid sugars cover the surface of dendritic cells (DCs) and have been suggested to impact several aspects of DC biology. Research into the role of sialic acids in DCs, howe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80609f571a91f7ea42622c0f48f6dd20
https://hdl.handle.net/2066/177820

Lipid Droplets as Immune Modulators in Myeloid Cells

Autor: Tonke K. Raaijmakers, Gosse J. Adema, Estel Collado-Camps, Martijn H. den Brok

Publikováno v: Trends in Immunology, 39, 380-392
Trends in Immunology, 39, 5, pp. 380-392

Contains fulltext : 193622.pdf (Publisher’s version ) (Closed access) Lipid droplets (LDs) were initially described as fat storage organelles in adipocytes, but are increasingly recognized as dynamic players in lipid metabolism, with important role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be09127820bb5fb983f8258854c4b70
https://pubmed.ncbi.nlm.nih.gov/29478771