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pro vyhledávání: '"Estefania Hugo Caselli"'
Autor:
Jonathan A. Ellman, Estefania Hugo Caselli, Hai-Chao Xu, Somenath Chowdhury, Clifford Bryant, Steven Chen, Servando Ponce, Michelle R. Arkin, R. Jeffrey Neitz, Jiri Gut, Adam R. Renslo
Publikováno v:
Bioorganic & medicinal chemistry letters, vol 25, iss 21
Inhibition of the cysteine protease cruzain from Trypanosoma cruzi has been studied pre-clinically as a new chemotherapeutic approach to treat Chagas’ disease. Efficacious effects of vinylsulfone-based cruzain inhibitors in animal models support th