Výsledky vyhledávání - "Estefanía Zacca"

B cells from Patients with Rheumatoid Arthritis Show Conserved CD39-Mediated Regulatory Function and increased CD39 Expression After Positive Response to Therapy

Autor: S.N. Bossio, Laura Onetti, E.V. Acosta Rodríguez, Eduardo Mussano, C.L. Montes, Nicolás Eric Ponce, Isaac I. Cadile, Cristina del Valle Acosta, M.C. Amezcua Vesely, Adriana Gruppi, Paola Virginia Ferrero, Estefanía Zacca

Publikováno v: J Mol Biol
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by progressive joint destruction associated with increased pro-inflammatory mediators. In inflammatory microenvironments, exogenous ATP (eATP) is hydrolyzed to adenosine, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81078d915dfa48c18ef30d8b11eb8bf0
https://pubmed.ncbi.nlm.nih.gov/33098857

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PD-L1+ Regulatory B Cells Are Significantly Decreased in Rheumatoid Arthritis Patients and Increase After Successful Treatment

Autor: Maria C. Taboada Bonfanti, Isaac I. Cadile, Carolina Lucia Montes, Sergio Manuel Alonso, Estefanía Zacca, Luisina Inés Onofrio, Maria I. Stancich, Adriana Gruppi, Eduardo Mussano, María Cecilia Ramello, Eva Virginia Acosta Rodriguez, Laura Onetti, Paola Virginia Ferrero, Cristina del Valle Acosta

Publikováno v: Frontiers in Immunology
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Frontiers in Immunology, Vol 9 (2018)

Background: B cells play an important role in the development and maintenance of rheumatoid arthritis (RA). Although IL-10-producing B cells represent a major subset of regulatory B cells (Bregs) able to suppress autoimmune and inflammatory responses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3faea3989e63cf75ead5b504b2e7e8b6
http://europepmc.org/articles/PMC6174216

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Inhibitory Receptor Expression on T Cells as a Marker of Disease Activity and Target to Regulate Effector Cellular Responses in Rheumatoid Arthritis

Autor: Eduardo Mussano, Eva Virginia Acosta Rodriguez, Isaac I. Cadile, M. Victoria Gazzoni, María Cecilia Ramello, Cristina del Valle Acosta, Paola Virginia Ferrero, Jimena Tosello Boari, Luisina Inés Onofrio, Raúl Jurado, Estefanía Zacca, Carolina L. Montes, Adriana Gruppi, Laura Onetti

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Objective: Inhibitory receptors are essential for the regulation of effector immune responses and may play critical roles in autoimmune diseases. We evaluated whether inhibitory receptor expression on T cells from patients with rheumatoid arthritis (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d014cc8b1c21d9fa23f48f663fc74c60
Wiley Online Library

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TLR7 triggering with polyuridylic acid promotes cross-presentation in CD8α+ conventional dendritic cells by enhancing antigen preservation and MHC class I antigen permanence on the dendritic cell surface

Autor: Romina P. Ranocchia, Estefanía Zacca, María C. Pistoresi-Palencia, María I. Crespo, Nicolás Gonzalo Núñez, Gabriel Morón, Belkys A. Maletto, Mariana Maccioni

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

ssRNA can interact with dendritic cells (DCs) through binding to TLR7, inducing secretion of proinflammatory cytokines and type I IFN. Triggering TLR7 enhances cross-priming of CD8+ T cells, which requires cross-presentation of exogenous Ag to DCs. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec63a685fd2e4a36fcbe01a1a662b83
https://pubmed.ncbi.nlm.nih.gov/23284054

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Aging Impairs the Ability of Conventional Dendritic Cells to Cross-Prime CD8+ T Cells upon Stimulation with a TLR7 Ligand

Autor: Gabriel Morón, Belkys A. Maletto, María C. Pistoresi-Palencia, Rachel P. Acland, Mariana Maccioni, Emiliano Roselli, Nicolás Gonzalo Núñez, María I. Crespo, Estefanía Zacca

Publikováno v: PLoS ONE
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS ONE, Vol 10, Iss 10, p e0140672 (2015)

The aging process is accompanied by altered immune system functioning and an increased risk of infection. Dendritic cells (DCs) are antigen-presenting cells that play a key role in both adaptive and innate immunity, but how aging affects DCs and thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7276b0a4239530617bcf676a0a05ab90
https://doi.org/10.1371/journal.pone.0140672

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