RhoA downregulation in the murine intestinal epithelium results in chronic Wnt activation and increased tumorigenesis

Autor: Higinio Dopeso, Paulo Rodrigues, Fernando Cartón-García, Irati Macaya, Josipa Bilic, Estefanía Anguita, Li Jing, Bruno Brotons, Núria Vivancos, Laia Beà, Manuel Sánchez-Martín, Stefania Landolfi, Javier Hernandez-Losa, Santiago Ramon y Cajal, Rocío Nieto, María Vicario, Ricard Farre, Simo Schwartz, Jr., Sven C.D. van Ijzendoorn, Kazuto Kobayashi, Águeda Martinez-Barriocanal, Diego Arango

Publikováno v: iScience, Vol 27, Iss 4, Pp 109400- (2024)

Summary: Rho GTPases are molecular switches regulating multiple cellular processes. To investigate the role of RhoA in normal intestinal physiology, we used a conditional mouse model overexpressing a dominant negative RhoA mutant (RhoAT19N) in the in

Externí odkaz: https://doaj.org/article/9d852163178f465ea052ec089ed5a27d

Myosin Vb as a tumor suppressor gene in intestinal cancer

Autor: Fernando Cartón-García, Bruno Brotons, Estefanía Anguita, Higinio Dopeso, Jordi Tarragona, Rocio Nieto, Elia García-Vidal, Irati Macaya, Zsuzsanna Zagyva, Mariona Dalmau, Manuel Sánchez-Martín, Sven C. D. van Ijzendoorn, Stefania Landolfi, Javier Hernandez-Losa, Simo Schwartz Jr, Xavier Matias-Guiu, Santiago Ramón y Cajal, Águeda Martínez-Barriocanal, Diego Arango

Publikováno v: ONCOGENE, 41. Nature Publishing Group

Colorectal cancer causes >900,000 deaths every year and a deeper understanding of the molecular mechanisms underlying this disease will contribute to improve its clinical management and survival. Myosin Vb (MYO5B) regulates intracellular vesicle traf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d7cbaf75f5558f1b08187aab072e063
https://hdl.handle.net/11370/a6122fb5-603a-40f9-ab87-d766afa97f46

Identification of ZBTB18 as a novel colorectal tumor suppressor gene through genome-wide promoter hypermethylation analysis

Autor: Estefanía Anguita, Jing Li, John M. Mariadason, Valentina Maggio, Lauri A. Aaltonen, Diego Arango, Rocio Nieto, Águeda Martínez-Barriocanal, Elia García-Vidal, Simó Schwartz, Paulo Rodrigues, Sarah Bazzocco, Higinio Dopeso, Alex Sánchez, Priscila Guimarães de Marcondes

Publikováno v: Clinical Epigenetics
Scientia
Dipòsit Digital de la UB
Universidad de Barcelona
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona

Càncer colorectal; Metilació; Dit de zinc Cáncer colorrectal; Metilación; Dedo de zinc Colorectal cancer; Methylation; Zinc finger Background Cancer initiation and progression are driven by genetic and epigenetic changes. Although genome/exome se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6ab31fdfd17a0d3b9bca39f84989533
http://europepmc.org/articles/PMC8063439

Ca2+ signaling and Src-kinases-controlled cellular functions

Autor: Antonio Villalobo, Estefanía Anguita

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Calcium-mediated signaling and the functionality of Src-family tyrosine kinases (SFKs) are two interconnected processes. Activation of these kinases, which are coupled to a series of receptors, mediates Ca2+ mobilization by regulating Ca2+ channels,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d117403535dd7b585e3e8abfafe197e4
http://hdl.handle.net/10261/188053

Abstract 840: Identification of novel colorectal tumor suppressor genes through genome-wide promoter hypermethylation analysis

Autor: Sarah Bazzocco, Jose Higinio Dopeso, Águeda Martínez-Barriocanal, Estefanía Anguita, Rocio Nieto, Alex Sanchez, John M. Mariadason, Diego Arango

Publikováno v: Cancer Research. 79:840-840

Cancer initiation and progression are driven by both genetic and epigenetic changes. Although recent genome/exome sequencing efforts have significantly contributed to the thorough characterization of the genetic changes associated with the oncogenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06b843184fff78bbf7962ec9550df059
https://doi.org/10.1158/1538-7445.am2019-840