NF-κB-inducing kinase (NIK) is activated in pancreatic β-cells but does not contribute to the development of diabetes

Autor: Peng Xiao, Tatiana Takiishi, Natalia Moretti Violato, Giada Licata, Francesco Dotta, Guido Sebastiani, Lorella Marselli, Sumeet Pal Singh, Mozes Sze, Geert Van Loo, Emmanuel Dejardin, Esteban Nicolas Gurzov, Alessandra Kupper Cardozo

Publikováno v: Cell Death and Disease, Vol 13, Iss 5, Pp 1-11 (2022)

Abstract The transcription factor nuclear factor-κB (NF-κB) has a key role in the pathogenesis of diabetes and its complications. Although activation of the canonical NF-κB pathway in β-cells is generally deleterious, little is known about the ro

Externí odkaz: https://doaj.org/article/1277c1357f0c4eb8aed8ef4ecac0ad73

Metabolite-based dietary supplementation in human type 1 diabetes is associated with microbiota and immune modulation

Autor: Sara Bordbar, Charles R. Mackay, Stephen M. Twigg, Eliana Mariño, Shannon Brodie, Sonia Saad, Marc R. Wilkins, Barbara Fazekas de St Groth, Long T. Nguyen, Emma E. Hamilton-Williams, Bree J. Tillett, Susan M. Corley, Courtney J. Wright, Helen M. McGuire, Yu Anne Yap, Kirstine J. Bell, Sussan Duong, Esteban Nicolas Gurzov, Leonard C. Harrison

BackgroundShort-chain fatty acids (SCFAs) produced by the gut microbiota have beneficial anti-inflammatory and gut homeostasis effects and prevent type 1 diabetes (T1D) in mice. Reduced SCFA production indicates a loss of beneficial bacteria, commonl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81d99ceb0bb773c049b35a111f8cd051
https://doi.org/10.1101/2021.09.15.21263059

Novel Strategies to Protect and Visualize Pancreatic beta Cells in Diabetes

Autor: Martin Gotthardt, Rita S. Garcia Ribeiro, Esteban Nicolas Gurzov, Pu Chun Ke, Ulf Ahlgren

Publikováno v: Trends in Endocrinology and Metabolism, 31, 905-917
Trends in endocrinology and metabolism
Trends in Endocrinology & Metabolism
Trends in Endocrinology and Metabolism, 31, 12, pp. 905-917

Contains fulltext : 229460.pdf (Publisher’s version ) (Closed access) A common feature in the pathophysiology of different types of diabetes is the reduction of beta cell mass and/or impairment of beta cell function. Diagnosis and treatment of type

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af7b9a059e6d7e9232521687c058d93
https://doi.org/10.1016/j.tem.2020.10.002

Differential regulation of pro-inflammatory cytokine signalling by protein tyrosine phosphatases in pancreatic β-cells

Autor: Prerak Trivedi, William J Stanley, Helen E. Thomas, Andrew P Ap Sutherland, Esteban Nicolas Gurzov

Publikováno v: Journal of Molecular Endocrinology. 59:325-337

Type 1 diabetes (T1D) is characterized by the destruction of insulin-producing β-cells by immune cells in the pancreas. Pro-inflammatory including TNF-α, IFN-γ and IL-1β are released in the islet during the autoimmune assault and signal in β-cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::645711cdf95c4aab1c811f0aca55f25f
https://doi.org/10.1530/jme-17-0089

JNK Activation of BIM Promotes Hepatic Oxidative Stress, Steatosis, and Insulin Resistance in Obesity

Autor: Lokman Pang, Decio L. Eizirik, Jean Valéry Turatsinze, Kim Loh, Mariana Igoillo-Esteve, Esteban Nicolas Gurzov, William J Stanley, Daniel J. Gough, Eric Trepo, Christophe Moreno, Sara A Litwak, Arpeeta Sharma, Sandra Galic, Helen E. Thomas, Judy B. de Haan

Publikováno v: Diabetes. 66:2973-2986

The members of the BCL-2 family are crucial regulators of the mitochondrial pathway of apoptosis in normal physiology and disease. Besides their role in cell death, BCL-2 proteins have been implicated in the regulation of mitochondrial oxidative phos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cee18fa01548cdfd13bff33d750ef20
https://doi.org/10.2337/db17-0348