Zobrazeno 1 - 10
of 690
pro vyhledávání: '"Esteban N"'
Autor:
Javier Negueruela, Valerie Vandenbempt, Stephanie Talamantes, Francisco Ribeiro-Costa, Mariana Nunes, André Dias, Mayank Bansal, Esteban N. Gurzov
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103297- (2024)
Summary: Gene editing of human pluripotent stem cells is a promising approach for developing targeted gene therapies for metabolic diseases. Here, we present a protocol for generating a CRISPR-Cas12a gene knockout of protein tyrosine phosphatases in
Externí odkaz:
https://doaj.org/article/c8a881473ccd4570afc4e34c60812a51
Publikováno v:
Discover Environment, Vol 1, Iss 1, Pp 1-13 (2023)
Abstract Fireworks are widely celebrated worldwide but have raised environmental concerns due to pollutant emissions. This has prompted evolving legislation in many countries, necessitating scientific evidence for policy development. Existing literat
Externí odkaz:
https://doaj.org/article/f5a06abc41564c1dbde96d0dc9f1ee76
Autor:
Valerie Vandenbempt, Sema Elif Eski, Manoja K. Brahma, Ao Li, Javier Negueruela, Ylke Bruggeman, Stéphane Demine, Peng Xiao, Alessandra K. Cardozo, Nicolas Baeyens, Luciano G. Martelotto, Sumeet Pal Singh, Eliana Mariño, Conny Gysemans, Esteban N. Gurzov
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108694- (2024)
Summary: An altered gut microbiota is associated with type 1 diabetes (T1D), affecting the production of short-chain fatty acids (SCFA) and glucose homeostasis. We previously demonstrated that enhancing serum acetate and butyrate using a dietary supp
Externí odkaz:
https://doaj.org/article/5023158edf454661a1c63b4ee36c62b7
Autor:
Stephanie Talamantes, Michela Lisjak, Eduardo H. Gilglioni, Camilo J. Llamoza-Torres, Bruno Ramos-Molina, Esteban N. Gurzov
Publikováno v:
JHEP Reports, Vol 5, Iss 9, Pp 100811- (2023)
Summary: Obesity-related complications such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D) are well-established risk factors for the development of hepatocellular carcinoma (HCC). This review provides insights into the molecul
Externí odkaz:
https://doaj.org/article/bdc6868083954ef9bc3215c297727189
Autor:
Tatiana Takiishi, Peng Xiao, Marie Franchimont, Eduardo H. Gilglioni, Erick N. Arroba, Esteban N. Gurzov, Mathieu JM. Bertrand, Alessandra K. Cardozo
Publikováno v:
Molecular Metabolism, Vol 69, Iss , Pp 101681- (2023)
Objectives: Type 1 diabetes (T1D) is caused by progressive immune-mediated loss of insulin-producing β-cells. Inflammation is detrimental to β-cell function and survival, moreover, both apoptosis and necrosis have been implicated as mechanisms of
Externí odkaz:
https://doaj.org/article/43ae0b3ebd974c21b9e2c60cf2ed9866
Autor:
Kirstine J. Bell, Sonia Saad, Bree J. Tillett, Helen M. McGuire, Sara Bordbar, Yu Anne Yap, Long T. Nguyen, Marc R. Wilkins, Susan Corley, Shannon Brodie, Sussan Duong, Courtney J. Wright, Stephen Twigg, Barbara Fazekas de St Groth, Leonard C. Harrison, Charles R. Mackay, Esteban N. Gurzov, Emma E. Hamilton-Williams, Eliana Mariño
Publikováno v:
Microbiome, Vol 10, Iss 1, Pp 1-21 (2022)
Abstract Background Short-chain fatty acids (SCFAs) produced by the gut microbiota have beneficial anti-inflammatory and gut homeostasis effects and prevent type 1 diabetes (T1D) in mice. Reduced SCFA production indicates a loss of beneficial bacteri
Externí odkaz:
https://doaj.org/article/e25eb74805594ff78c91c45cb9747d55
Publikováno v:
PeerJ, Vol 10, p e13540 (2022)
Marine mammals are under pressure from multiple threats, such as global climate change, bycatch, and vessel collisions. In this context, more frequent and spatially extensive surveys for abundance and distribution studies are necessary to inform cons
Externí odkaz:
https://doaj.org/article/d3ac06e373d240c1a0dd1ea808f5b048
Autor:
Manoja K. Brahma, Peng Xiao, Madalina Popa, Javier Negueruela, Valerie Vandenbempt, Stéphane Demine, Alessandra K. Cardozo, Esteban N. Gurzov
Publikováno v:
Nutrients, Vol 14, Iss 18, p 3866 (2022)
The loss of functional pancreatic β-cell mass is an important hallmark of both type 1 and type 2 diabetes. The RNA-binding protein NOVA1 is expressed in human and rodent pancreatic β-cells. Previous in vitro studies indicated that NOVA1 is necessar
Externí odkaz:
https://doaj.org/article/b2ffeed846254c9991fc894933ce7e70
Autor:
Gabriel S. Vignoli Muniz, Lilia I. De la Torre, Evandro L. Duarte, Esteban N. Lorenzón, Eduardo M. Cilli, Andrea Balan, M. Teresa Lamy
Publikováno v:
Biochemistry and Biophysics Reports, Vol 24, Iss , Pp 100827- (2020)
Antimicrobial peptides (AMPs) have been appointed as a possible alternative to traditional antibiotics in face of pathogens increasing resistance to conventional drugs. Hylin a1 (IFGAILPLALGALKNLIK), an AMP extracted from the skin secretion of a Sout
Externí odkaz:
https://doaj.org/article/7c09fc9020604e86937312db3c12a4ac
Autor:
Kim Loh, Yan-Chuan Shi, Stacey Walters, Mohammed Bensellam, Kailun Lee, Katsuya Dezaki, Masanori Nakata, Chi Kin Ip, Jeng Yie Chan, Esteban N. Gurzov, Helen E. Thomas, Michaela Waibel, James Cantley, Thomas W. Kay, Toshihiko Yada, D. Ross Laybutt, Shane T. Grey, Herbert Herzog
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Islet transplantation is considered one of the potential treatments for T1DM but limited islet survival and their impaired function pose limitations to this approach. Here Loh et al. show that the Y1 receptor is expressed in β- cells and inhibition
Externí odkaz:
https://doaj.org/article/99ec06e40ce64866b58ef492f2dc58bd