Zobrazeno 1 - 10
of 482
pro vyhledávání: '"Esteban Domingo"'
Publikováno v:
npj Viruses, Vol 2, Iss 1, Pp 1-11 (2024)
Abstract Quasispecies theory revolutionized our understanding of viral evolution by describing viruses as dynamic populations of genetically diverse variants constantly adapting. This article explores the theory’s role in virus-host interactions, i
Externí odkaz:
https://doaj.org/article/a607f47feb404195b5851e28d9dea766
Autor:
Carlos Raico Landa, Ascensión Ariza-Mateos, Carlos Briones, Celia Perales, Astrid Wagner, Esteban Domingo, Jordi Gómez
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The rhizome concept proposed by Gilles Deleuze and Félix Guattari offers a novel perspective on the organization and interdependence of complex constellations of heterogeneous entities, their mapping and their ruptures. The emphasis of the
Externí odkaz:
https://doaj.org/article/d0985f8cf2ee493eb418f7d301fba074
Autor:
Brenda Martínez-González, María Eugenia Soria, Pablo Mínguez, Ramón Lorenzo-Redondo, Llanos Salar-Vidal, Alberto López-García, Mario Esteban-Muñoz, Antoni Durán-Pastor, Pilar Somovilla, Carlos García-Crespo, Ana Isabel de Ávila, Jordi Gómez, Jaime Esteban, Ricardo Fernández-Roblas, Ignacio Gadea, Esteban Domingo, Celia Perales
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
IntroductionSARS-CoV-2 isolates of a given clade may contain low frequency genomes that encode amino acids or deletions which are typical of a different clade.MethodsHere we use high resolution ultra-deep sequencing to analyze SARS-CoV-2 mutant spect
Externí odkaz:
https://doaj.org/article/2458e84b3aad42eba6e7b16a7f27dfbb
Autor:
Carlos García-Crespo, Irene Francisco-Recuero, Isabel Gallego, Marina Camblor-Murube, María Eugenia Soria, Ana López-López, Ana Isabel de Ávila, Antonio Madejón, Javier García-Samaniego, Esteban Domingo, Aurora Sánchez-Pacheco, Celia Perales
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
IntroductionCellular epigenetic modifications occur in the course of viral infections. We previously documented that hepatitis C virus (HCV) infection of human hepatoma Huh-7.5 cells results in a core protein-mediated decrease of Aurora kinase B (AUR
Externí odkaz:
https://doaj.org/article/b3cc1a83b8ad4731aee542b53c738838
Autor:
Flavia Caridi, Rodrigo Cañas-Arranz, Ángela Vázquez-Calvo, Patricia de León, Katherine I. Calderón, Esteban Domingo, Francisco Sobrino, Miguel A. Martín-Acebes
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Foot-and-mouth disease virus (FMDV) is a picornavirus that exhibits an extremely acid sensitive capsid. This acid lability is directly related to its mechanism of uncoating triggered by acidification inside cellular endosomes. Using a collec
Externí odkaz:
https://doaj.org/article/2f4df36e32514ec9bf512bbce68573e8
Autor:
Carlos García-Crespo, Lucía Vázquez-Sirvent, Pilar Somovilla, María Eugenia Soria, Isabel Gallego, Ana Isabel de Ávila, Brenda Martínez-González, Antoni Durán-Pastor, Esteban Domingo, Celia Perales
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
We report a quantification of the decrease of effectiveness of antiviral agents directed to hepatitis C virus, when the agents are added during an ongoing infection in cell culture vs. when they are added at the beginning of the infection. Major dete
Externí odkaz:
https://doaj.org/article/73c6d82bbe8845b18dff3ceda6ce6cbc
Autor:
Brenda Martínez-González, Lucía Vázquez-Sirvent, María E. Soria, Pablo Mínguez, Llanos Salar-Vidal, Carlos García-Crespo, Isabel Gallego, Ana I. de Ávila, Carlos Llorens, Beatriz Soriano, Ricardo Ramos-Ruiz, Jaime Esteban, Ricardo Fernandez-Roblas, Ignacio Gadea, Carmen Ayuso, Javier Ruíz-Hornillos, Concepción Pérez-Jorge, Esteban Domingo, Celia Perales
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 9 (2022)
Replication of SARS-CoV-2 in the human population is defined by distributions of mutants that are present at different frequencies within the infected host and can be detected by ultra-deep sequencing techniques. In this study, we examined the SARS-C
Externí odkaz:
https://doaj.org/article/a4878f2c6b334c20baf2fe61091dfbe2
SARS-CoV-2 Point Mutation and Deletion Spectra and Their Association with Different Disease Outcomes
Autor:
Brenda Martínez-González, María Eugenia Soria, Lucía Vázquez-Sirvent, Cristina Ferrer-Orta, Rebeca Lobo-Vega, Pablo Mínguez, Lorena de la Fuente, Carlos Llorens, Beatriz Soriano, Ricardo Ramos, Marta Cortón, Rosario López-Rodríguez, Carlos García-Crespo, Isabel Gallego, Ana Isabel de Ávila, Jordi Gómez, Luis Enjuanes, Llanos Salar-Vidal, Jaime Esteban, Ricardo Fernandez-Roblas, Ignacio Gadea, Carmen Ayuso, Javier Ruíz-Hornillos, Nuria Verdaguer, Esteban Domingo, Celia Perales
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 2 (2022)
ABSTRACT Mutant spectra of RNA viruses are important to understand viral pathogenesis and response to selective pressures. There is a need to characterize the complexity of mutant spectra in coronaviruses sampled from infected patients. In particular
Externí odkaz:
https://doaj.org/article/6d9736d4a3d14394be76e5f75a5176ca
Autor:
Rosario Sabariegos, Ana María Ortega-Prieto, Luis Díaz-Martínez, Ana Grande-Pérez, Carlos García Crespo, Isabel Gallego, Ana I de Ávila, Laura Albentosa-González, María Eugenia Soria, Pablo Gastaminza, Esteban Domingo, Celia Perales, Antonio Mas
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1010210 (2022)
In the course of experiments aimed at deciphering the inhibition mechanism of mycophenolic acid and ribavirin in hepatitis C virus (HCV) infection, we observed an inhibitory effect of the nucleoside guanosine (Gua). Here, we report that Gua, and not
Externí odkaz:
https://doaj.org/article/2f919a8f2d6b481da74b22cb86838e32
Autor:
Soledad Delgado, Celia Perales, Carlos García-Crespo, María Eugenia Soria, Isabel Gallego, Ana Isabel de Ávila, Brenda Martínez-González, Lucía Vázquez-Sirvent, Cecilio López-Galíndez, Federico Morán, Esteban Domingo
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 3 (2021)
ABSTRACT RNA viruses replicate as complex mutant spectra termed viral quasispecies. The frequency of each individual genome in a mutant spectrum depends on its rate of generation and its relative fitness in the replicating population ensemble. The ad
Externí odkaz:
https://doaj.org/article/041d5980a232449789212264732757dd