Hybrid mass spectrometry methods reveal lot-to-lot differences and delineate the effects of glycosylation on the tertiary structure of Herceptin®† †Electronic supplementary information (ESI) available: Supporting results (Fig. S1–S23 and Tables S1–S3) as mentioned in the text. See DOI: 10.1039/c8sc05029e

Autor: Upton, Rosie, Migas, Lukasz G., Pacholarz, Kamila J, Beniston, Richard G., Peters, Shirley, Davis, Rachel, Estdale, Sian, Firth, David, Barran, Perdita

Publikováno v: Chemical Science
Upton, R, Migas, L G, Pacholarz, K J, Beniston, R G, Peters, S, Davis, R, Estdale, S, Firth, D & Barran, P 2019, ' Hybrid Mass Spectrometry Methods Reveal Lot-to-Lot Differences and Delineate the Effects of Glycosylation on the Tertiary Structure of Herceptin ', Chemical Science . https://doi.org/10.1039/C8SC05029E

To quantify the measurable structural heterogeneity of a biopharmaceutical product and the effect of glycosylation on this we systematically evaluate three lots of Herceptin®, two mAb standards and an intact 5 Fc-hinge fragment.
To quantify the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb3f87d6ed07fe5d965f65b243753cf
http://europepmc.org/articles/PMC6425993

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Prostaglandin production by melanocytic cells and the effect of α-melanocyte stimulating hormone

Autor: Nicolaou, Anna, Estdale, Sian E, Tsatmali, Marina, Herrero, Daniel Pascual, Thody, Anthony J

Publikováno v: In FEBS Letters 2004 570(1):223-226

Synthesis, linear dichroism and mesogenic properties of substituted azulenes.

Autor: Brettle, Roger, Dunmur, David A., Estdale, Sian, Marson, Charles M.

Publikováno v: Journal of Materials Chemistry; Apr1993, Vol. 3 Issue 4, p327-331, 5p