Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Estíbaliz, Miranda"'
Autor:
Iñigo Apaolaza, Edurne San José-Eneriz, Luis Tobalina, Estíbaliz Miranda, Leire Garate, Xabier Agirre, Felipe Prósper, Francisco J. Planes
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Exploiting synthetic lethality is a promising approach for cancer therapy. Here, the authors present an approach to identifying such interactions by finding genetic minimal cut sets (gMCSs) that block cancer proliferation, and apply it to study the l
Externí odkaz:
https://doaj.org/article/ef8cc22898f64ca2b56b0ae347ed3a4f
Autor:
Nicolás Martínez-Calle, Marien Pascual, Raquel Ordoñez, Edurne San José Enériz, Marta Kulis, Estíbaliz Miranda, Elisabeth Guruceaga, Víctor Segura, María José Larráyoz, Beatriz Bellosillo, María José Calasanz, Carles Besses, José Rifón, José I. Martín-Subero, Xabier Agirre, Felipe Prosper
Publikováno v:
Haematologica, Vol 104, Iss 8 (2019)
In this study we interrogated the DNA methylome of myelofibrosis patients using high-density DNA methylation arrays. We detected 35,215 differentially methylated CpG, corresponding to 10,253 genes, between myelofibrosis patients and healthy controls.
Externí odkaz:
https://doaj.org/article/92c068858094471b9449973937dec2fd
Autor:
Marian Gimeno, Edurne San José-Enériz, Angel Rubio, Leire Garate, Estíbaliz Miranda, Carlos Castilla, Xabier Agirre, Felipe Prosper, Fernando Carazo
Publikováno v:
Cancers; Volume 14; Issue 13; Pages: 3251
Recent functional genomic screens—such as CRISPR-Cas9 or RNAi screening—have fostered a new wave of targeted treatments based on the concept of synthetic lethality. These approaches identified LEthal Dependencies (LEDs) by estimating the effect o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f7635bca086c3c50526b15a6507a26
Autor:
Elena Sáez, Musheng Xu, Raquel Ordoñez, Amaia Vilas-Zornoza, Feifei Zhang, Xabier Agirre, Antonio Pineda-Lucena, Obdulia Rabal, Julen Oyarzabal, Felipe Prosper, Edurne San José-Enériz, Estíbaliz Miranda, Irene de Miguel, Leire Garate, Juan A. Sánchez-Arias, Ander Estella, Wei Wu
Publikováno v:
Journal of Medicinal Chemistry. 64:3392-3426
Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe8ef28e03f4b1381fbbbd762da2c60a
https://doi.org/10.1021/acs.jmedchem.0c02255
https://doi.org/10.1021/acs.jmedchem.0c02255
Autor:
Jesús F. San Miguel, Marta Kulis, Elisabeth Guruceaga, Arantxa Carrasco-Leon, Felipe Prosper, Raquel Ordoñez, Ane Amundarain, Leire Garate, Cem Meydan, Teresa Ezponda, Laura Castro-Labrador, Xabier Agirre, José I. Martín-Subero, Ari Melnick, Marien Pascual, Estíbaliz Miranda, Amaia Vilas-Zornoza, Christopher E. Mason, Bruno Paiva, Halima El-Omri, Patxi San Martin-Uriz, Diego Alignani, María José Calasanz, Luis Vitores Valcárcel, Ruba Y. Taha, Francisco J. Planes, Victor Segura
Publikováno v:
Leukemia
Multiple myeloma (MM) is an incurable disease, whose clinical heterogeneity makes its management challenging, highlighting the need for biological features to guide improved therapies. Deregulation of specific long non-coding RNAs (lncRNAs) has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0747eda6958befd5fd5627a104151d6a
https://doi.org/10.1038/s41375-021-01147-y
https://doi.org/10.1038/s41375-021-01147-y
Autor:
Ane Amundarain, Luis V. Valcárcel, Raquel Ordoñez, Leire Garate, Estíbaliz Miranda, Xabier Cendoya, Arantxa Carrasco‐Leon, María José Calasanz, Bruno Paiva, Cem Meydan, Christopher E. Mason, Ari Melnick, Paula Rodriguez‐Otero, José I. Martín‐Subero, Jesús San Miguel, Francisco J. Planes, Felipe Prósper, Xabier Agirre
Publikováno v:
American Journal of Hematology. 97
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d9507a1847567fd2dbed92ab3d74a1
https://doi.org/10.1002/ajh.26450
https://doi.org/10.1002/ajh.26450
Autor:
Fernando Carazo, Edurne San José-Enériz, Marian Gimeno, Leire Garate, Estíbaliz Miranda, Carlos Castilla, Xabier Agirre, Ángel Rubio, Felipe Prósper
Recent functional genomic screens -such as CRISPR-Cas9 or RNAi screening-have fostered a new wave of targeted treatments based on the concept of synthetic lethality. These approaches identified LEthal Dependencies (LEDs) by estimating the effect of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a323417f2388cd9c6f85258fd5d6f2ed
https://doi.org/10.1101/2021.10.29.466419
https://doi.org/10.1101/2021.10.29.466419
Autor:
Puri Fortes, José A. Casado, Jesús M. Paramio, Obdulia Rabal, Cristian Suárez-Cabrera, Marta Dueñas, Cristina Segovia, Carmen Segrelles, Noelia Casares, Juan José Lasarte, Xabier Agirre, Felix Guerrero-Ramos, Iris Lodewijk, Ester Munera-Maravilla, Amaia Vilas-Zornoza, Leire Garate, Guillermo Velasco, Edurne San José-Enériz, Julen Oyarzabal, Mónica Martínez-Fernández, Estíbaliz Miranda, Fernando F. López-Calderón, Alejandra Bernardini, Luis Vitores Valcárcel, Felipe Villacampa, Daniel Castellano, Carolina Rubio, Felipe Prosper
Publikováno v:
Translational Cancer Research
Bladder cancer is lethal in its advanced, muscle-invasive phase with very limited therapeutic advances1,2. Recent molecular characterization has defined new (epi)genetic drivers and potential targets for bladder cancer3,4. The immune checkpoint inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c009cbe5038a15337e3366fe4d4d4816
https://doi.org/10.1038/s41591-019-0499-y
https://doi.org/10.1038/s41591-019-0499-y
Autor:
Obdulia, Rabal, Edurne, San José-Enériz, Xabier, Agirre, Juan Antonio, Sánchez-Arias, Irene, de Miguel, Raquel, Ordoñez, Leire, Garate, Estíbaliz, Miranda, Elena, Sáez, Amaia, Vilas-Zornoza, Antonio, Pineda-Lucena, Ander, Estella, Feifei, Zhang, Wei, Wu, Musheng, Xu, Felipe, Prosper, Julen, Oyarzabal
Publikováno v:
Journal of medicinal chemistry. 64(6)
Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bad3640d9d5cb27668dc78f6b1e780a3
https://pubmed.ncbi.nlm.nih.gov/33661013
https://pubmed.ncbi.nlm.nih.gov/33661013
Autor:
Amaia Vilas-Zornoza, Xabier Agirre, Vanesa Martín-Palanco, José Ignacio Martín-Subero, Edurne San José-Eneriz, Leire Garate, Sara Álvarez, Estíbaliz Miranda, Paula Rodríguez-Otero, José Rifón, Antonio Torres, María José Calasanz, Juan Cruz Cigudosa, José Román-Gómez, Felipe Prósper
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17012 (2011)
Aberrant DNA methylation is one of the most frequent alterations in patients with Acute Lymphoblastic Leukemia (ALL). Using methylation bead arrays we analyzed the methylation status of 807 genes implicated in cancer in a group of ALL samples at diag
Externí odkaz:
https://doaj.org/article/6e39c3a5691b497a9b4284448183bded