Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Estéfano, Pinilla"'
Autor:
Lilliana Beck, Estéfano Pinilla, Daniel Dias Rufino Arcanjo, Raquel Hernanz, Judit Prat-Duran, Asbjørn Graver Petersen, Ralf Köhler, Majid Sheykhzade, Simon Comerma-Steffensen, Ulf Simonsen
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Endothelial cell dysfunction and fibrosis are associated with worsening of the prognosis in patients with cardiovascular disease. Pirfenidone has a direct antifibrotic effect, but vasodilatation may also contribute to the effects of pirfenidone. Ther
Externí odkaz:
https://doaj.org/article/34134b1c93264b05a5e166de31839f1e
Autor:
Lilliana Beck, Junjing Su, Simon Comerma-Steffensen, Estéfano Pinilla, Rune Carlsson, Raquel Hernanz, Majid Sheykhzade, Carl Christian Danielsen, Ulf Simonsen
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Endothelial cell dysfunction and vessel stiffening are associated with a worsened prognosis in diabetic patients with cardiovascular diseases. The present study hypothesized that sex impacts endothelial dysfunction and structural changes in arteries
Externí odkaz:
https://doaj.org/article/8f9bcd1d62d84f4aa8c081719c8906b4
Autor:
Karen Axelgaard Lorentzen, Raquel Hernanz, Estéfano Pinilla, Jens Randel Nyengaard, Lise Wogensen, Ulf Simonsen
Publikováno v:
Lorentzen, K A, Hernanz, R, Pinilla, E, Nyengaard, J R, Wogensen, L & Simonsen, U 2023, ' Sex-Dependent Impairment of Endothelium-Dependent Relaxation in Aorta of Mice with Overexpression of Hyaluronan in Tunica Media ', International Journal of Molecular Sciences, vol. 24, no. 9 . https://doi.org/10.3390/ijms24098436
International Journal of Molecular Sciences; Volume 24; Issue 9; Pages: 8436
International Journal of Molecular Sciences; Volume 24; Issue 9; Pages: 8436
Diabetic macroangiopathy is characterized by increased extracellular matrix deposition, including excessive hyaluronan accumulation, vessel thickening and stiffness, and endothelial dysfunction in large arteries. We hypothesized that the overexpressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a3393c638058f4dd90d0ac009ea442
https://pure.au.dk/portal/da/publications/sexdependent-impairment-of-endotheliumdependent-relaxation-in-aorta-of-mice-with-overexpression-of-hyaluronan-in-tunica-media(7c2129cc-df94-4736-bcfc-173fee213736).html
https://pure.au.dk/portal/da/publications/sexdependent-impairment-of-endotheliumdependent-relaxation-in-aorta-of-mice-with-overexpression-of-hyaluronan-in-tunica-media(7c2129cc-df94-4736-bcfc-173fee213736).html
Autor:
Lars Kjøbstad Markvardsen, Estéfano Pinilla, Lene D Sønderskov, Mathilde Aalling, Christine Wandall-Frostholm, Ulf Simonsen, Susie Mogensen, Charlotte Andersen, Judit Prat-Duran
Publikováno v:
Markvardsen, L K, Sønderskov, L D, Wandall-Frostholm, C, Pinilla, E, Prat-Duran, J, Aalling, M, Mogensen, S, Andersen, C U & Simonsen, U 2021, ' Cystamine Treatment Fails to Prevent the Development of Pulmonary Hypertension in Chronic Hypoxic Rats ', Journal of Vascular Research, vol. 58, no. 4, pp. 237-251 . https://doi.org/10.1159/000515511
Introduction: Pulmonary hypertension is characterized by vasoconstriction and remodeling of pulmonary arteries, leading to right ventricular hypertrophy and failure. We have previously found upregulation of transglutaminase 2 (TG2) in the right ventr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::029daccd3f91599135cd21a46abe7715
https://doi.org/10.1159/000515511
https://doi.org/10.1159/000515511
Autor:
Elvira López-Oliva, Dolores Prieto, Estéfano Pinilla, Alfonso Gómez, Javier Sáenz-Medina, Sara Benedito, María Pilar Martínez, Mercedes Muñoz, Luis Rivera, Cristina Contreras, Claudia Rodríguez
Publikováno v:
Muñoz Picos, M, López-Oliva, E, Pinilla, E, Rodríguez, C, Pilar Martínez, M, Contreras, C, Gómez, A, Benedito, S, Sáenz-Medina, J, Rivera, L & Prieto, D 2021, ' Differential Contribution of Renal Cytochrome P450 Enzymes to Kidney Endothelial Dysfunction and Vascular Oxidative Stress in Obesity ', Biochemical Pharmacology, pp. 114850 . https://doi.org/10.1016/j.bcp.2021.114850
E-Prints Complutense. Archivo Institucional de la UCM
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E-Prints Complutense. Archivo Institucional de la UCM
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Arachidonic acid (AA)-derived cytochrome P450 (CYP) derivatives, epoxyeicosatrienoic acids (EETs) and 20-hidroxyeicosatetranoic acid (20-HETE), play a key role in kidney tubular and vascular functions and blood pressure. Altered metabolism of CYP epo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4f14fc0e3bdb2091b1625e056ac145
https://pubmed.ncbi.nlm.nih.gov/34822809
https://pubmed.ncbi.nlm.nih.gov/34822809
Autor:
Daniel Dias Rufino Arcanjo, Majid Sheykhzade, Raquel Hernanz, Ralf Köhler, Simon Comerma-Steffensen, Judit Prat-Duran, Ulf Simonsen, Estéfano Pinilla, Lilliana Beck, Asbjørn Graver Petersen
Publikováno v:
Thinggaard, L B, Pinilla, E, Arcanjo, D D R, Hernanz, R, Prat Duran, J, Petersen, A, Köhler, R, Sheykhzade, M, Comerma Steffensen, S G & Simonsen, U 2021, ' Pirfenidone Is a Vasodilator: Involvement of KV7 Channels in the Effect on Endothelium-Dependent Vasodilatation in Type-2 Diabetic Mice ', Frontiers in Pharmacology, vol. 11, 619152 . https://doi.org/10.3389/fphar.2020.619152
Frontiers in Pharmacology, Vol 11 (2021)
Beck, L, Pinilla, E, Arcanjo, D D R, Hernanz, R, Prat-Duran, J, Petersen, A G, Köhler, R, Sheykhzade, M, Comerma-Steffensen, S & Simonsen, U 2021, ' Pirfenidone Is a Vasodilator : Involvement of K V 7 Channels in the Effect on Endothelium-Dependent Vasodilatation in Type-2 Diabetic Mice ', Frontiers in Pharmacology, vol. 11, 619152 . https://doi.org/10.3389/fphar.2020.619152
Frontiers in Pharmacology, Vol 11 (2021)
Beck, L, Pinilla, E, Arcanjo, D D R, Hernanz, R, Prat-Duran, J, Petersen, A G, Köhler, R, Sheykhzade, M, Comerma-Steffensen, S & Simonsen, U 2021, ' Pirfenidone Is a Vasodilator : Involvement of K V 7 Channels in the Effect on Endothelium-Dependent Vasodilatation in Type-2 Diabetic Mice ', Frontiers in Pharmacology, vol. 11, 619152 . https://doi.org/10.3389/fphar.2020.619152
Endothelial cell dysfunction and fibrosis are associated with worsening of the prognosis in patients with cardiovascular disease. Pirfenidone has a direct antifibrotic effect, but vasodilatation may also contribute to the effects of pirfenidone. Ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66abadbf891e3684b677a37e10c10a52
https://pure.au.dk/portal/da/publications/pirfenidone-is-a-vasodilator-involvement-of-kv7-channels-in-the-effect-on-endotheliumdependent-vasodilatation-in-type2-diabetic-mice(67bad165-322a-4e7b-af9b-19aeda4dd175).html
https://pure.au.dk/portal/da/publications/pirfenidone-is-a-vasodilator-involvement-of-kv7-channels-in-the-effect-on-endotheliumdependent-vasodilatation-in-type2-diabetic-mice(67bad165-322a-4e7b-af9b-19aeda4dd175).html
Autor:
Dolores Prieto, Estéfano Pinilla, Luis Rivera, Albino García-Sacristán, Ana Sánchez, María Pilar Martínez, Ralf Köhler, Mercedes Muñoz
Publikováno v:
Pinilla, E, Sánchez-Pina, A, Martínez, M P, Muñoz Picos, M, García-Sacristán, A, Köhler, R, Prieto, D & Rivera, L 2021, ' Endothelial K Ca 1.1 and K Ca 3.1 channels mediate rat intrarenal artery endothelium derived hyperpolarization response ', Acta Physiologica, vol. 231, no. 4, e13598 . https://doi.org/10.1111/apha.13598
Aim: Endothelium-derived hyperpolarization (EDH)-mediated response plays an essential role in the control of kidney preglomerular circulation, but the identity of the K+ channels involved in this response is still controversial. We hypothesized that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ccebd4fa50d4472ab91edfe0622638
https://doi.org/10.1111/apha.13598
https://doi.org/10.1111/apha.13598
Autor:
Estéfano, Pinilla, Ana, Sánchez, María P, Martínez, Mercedes, Muñoz, Albino, García-Sacristán, Ralf, Köhler, Dolores, Prieto, Luis, Rivera
Publikováno v:
Acta physiologica (Oxford, England)REFERENCES. 231(4)
Endothelium-derived hyperpolarization (EDH)-mediated response plays an essential role in the control of kidney preglomerular circulation, but the identity of the KWe study the functional expression of different KImmunofluorescence revealed the expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1a36fdcac7cd5bdc8cac764aebae3493
https://pubmed.ncbi.nlm.nih.gov/33314681
https://pubmed.ncbi.nlm.nih.gov/33314681
Autor:
Luis Rivera, Judit Prat-Duran, Ulf Simonsen, Vladimir V. Matchkov, Estéfano Pinilla, Simon Comerma-Steffensen, Niels H. Buus
Publikováno v:
Pinilla, E, Comerma Steffensen, S G, Prat Duran, J, Rivera, L, Matchkov, V, Buus, N H & Simonsen, U 2021, ' Transglutaminase 2 Inhibitor LDN 27219 Age-Dependently Lowers Blood Pressure and Improves Endothelium-Dependent Vasodilation in Resistance Arteries ', Hypertension, vol. 77, no. 1, pp. 216-227 . https://doi.org/10.1161/HYPERTENSIONAHA.120.15352
Transglutaminase 2 (TG2) is an enzyme which in the open conformation exerts transamidase activity, leading to protein cross-linking and fibrosis. In the closed conformation, TG2 participates in transmembrane signaling as a G protein. The unspecific t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118340e148db5be9389a7d1b4658dff8
https://pubmed.ncbi.nlm.nih.gov/33249864
https://pubmed.ncbi.nlm.nih.gov/33249864
Autor:
Lilliana, Beck, Estéfano, Pinilla, Daniel Dias Rufino, Arcanjo, Raquel, Hernanz, Judit, Prat-Duran, Asbjørn Graver, Petersen, Ralf, Köhler, Majid, Sheykhzade, Simon, Comerma-Steffensen, Ulf, Simonsen
Publikováno v:
Frontiers in Pharmacology
Endothelial cell dysfunction and fibrosis are associated with worsening of the prognosis in patients with cardiovascular disease. Pirfenidone has a direct antifibrotic effect, but vasodilatation may also contribute to the effects of pirfenidone. Ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::563d0012ddf4eaa0d7c294b92bf31f62
https://pubmed.ncbi.nlm.nih.gov/33643042
https://pubmed.ncbi.nlm.nih.gov/33643042