Development and implementation of a customised rapid syndromic diagnostic test for severe pneumonia [version 3; peer review: 2 approved]

Autor: Thomas P Hellyer, Vilas Navapurkar, Joana Pereira-Dias, Ellen Higginson, Petra Polgarova, Emma Heasman-Hunt, Lissamma Titti, Joanne Brown, Jonathan Scott, William PW Smith, David Sapsford, Anthony Rostron, Ronan McMullan, M. Estée Török, Vanessa Wong, David A Enoch, Martin D Curran, A John Simpson, Sally Forrest, Nicholas M Brown, Josefin Bartholdson Scott, Andrew Conway Morris, Jurgen Herre, Mailis Maes, Matthew Routledge, Surendra Parmar, Gordon Dougan

Publikováno v: Wellcome Open Research, Vol 6 (2022)

Background: The diagnosis of pneumonia has been hampered by a reliance on bacterial cultures which take several days to return a result, and are frequently negative. In critically ill patients this leads to the use of empiric, broad-spectrum antimicr

Externí odkaz: https://doaj.org/article/f065e84a244242ad92ad8327f4cb7f6e

A prospective study of risk factors associated with seroprevalence of SARS-CoV-2 antibodies in healthcare workers at a large UK teaching hospital

Autor: Daniel J Cooper, Sara Lear, Laura Watson, Ashley Shaw, Mark Ferris, Rainer Doffinger, Rachel Bousfield, Katherine Sharrocks, Michael P. Weekes, Ben Warne, Dominic Sparkes, Nick K Jones, Lucy Rivett, Matthew Routledge, Afzal Chaudhry, Katherine Dempsey, Montgomery Matson, Adil Lakha, George Gathercole, Olivia O'Connor, Emily Wilson, Orthi Shahzad, Kieran Toms, Rachel Thompson, Ian Halsall, David Halsall, Sally Houghton, Sofia Papadia, Nathalie Kingston, Kathleen E Stirrups, Barbara Graves, Paul Townsend, Neil Walker, Hannah Stark, Daniela De Angelis, Shaun Seaman, Gordon Dougan, John R Bradley, M. Estée Török, Ian Goodfellow, Stephen Baker

Publikováno v: Journal of Infection. 85:557-564

To describe the risk factors for SARS-CoV-2 infection in UK healthcare workers (HCWs).We conducted a prospective sero-epidemiological study of HCWs at a major UK teaching hospital using a SARS-CoV-2 immunoassay. Risk factors for seropositivity were a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285b31db7528f7a480ac8b1520bdadb3
https://doi.org/10.1016/j.jinf.2022.08.030

Evidence of widespread endemic populations of highly multidrug resistant Klebsiella pneumoniae in hospital settings in Hanoi, Vietnam: a prospective cohort study

Autor: My H Pham, Le Thi Hoi, Mathew A Beale, Fahad A Khokhar, Nguyen Thi Hoa, Patrick Musicha, Grace A Blackwell, Hoang Bao Long, Dang Thi Huong, Nguyen Gia Binh, Dao Xuan Co, Tran Giang, Cuong Bui, Hai Ninh Tran, James Bryan, Archie Herrick, Theresa Feltwell, Behzad Nadjm, Julian Parkhill, Hindrik Rogier van Doorn, Nguyen Vu Trung, Nguyen Van Kinh, Mili Estée Török, Nicholas R Thomson

BACKGROUND: Patients with prolonged hospitalisation have a significant risk of carriage of and subsequent infection with extended spectrum β-lactamase (ESBL)-producing and carbapenemase-producing Klebsiella pneumoniae. However, the distinctive roles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e431ae16c1efdcb1364328cc1515634
https://www.repository.cam.ac.uk/handle/1810/343571

The rapid detection of respiratory pathogens in critically ill children

Autor: John A. Clark, Andrew Conway Morris, Martin D. Curran, Deborah White, Esther Daubney, Iain R. L. Kean, Vilas Navapurkar, Josefin Bartholdson Scott, Mailis Maes, Rachel Bousfield, M. Estée Török, David Inwald, Zhenguang Zhang, Shruti Agrawal, Constantinos Kanaris, Fahad Khokhar, Theodore Gouliouris, Stephen Baker, Nazima Pathan

Funder: NIHR Cambridge Biomedical Research Centre
PURPOSE: Respiratory infections are the most common reason for admission to paediatric intensive care units (PICU). Most patients with lower respiratory tract infection (LRTI) receive broad-spect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a09289669fe265c80e46972480b281
https://www.repository.cam.ac.uk/handle/1810/345257

Challenges and opportunities for conducting a vaccine trial during the COVID-19 pandemic in the United Kingdom

Autor: M Estée Török, Benjamin R Underwood, Mark Toshner, Claire Waddington, Emad Sidhom, Katherine Sharrocks, Rachel Bousfield, Charlotte Summers, Caroline Saunders, Zoe McIntyre, Helen Morris, Jo Piper, Gloria Calderon, Sarah Dennis, Tracy Assari, Anita Marguerie de Rotrou, Ashley Shaw, John Bradley, John O’Brien, Robert C Rintoul, Ian Smith, Ed Bullmore, Krishna Chatterjee, Carla Ribeiro, Lorinda Pickup, Ranalie de Jesus, Karen Brookes, Phoebe Vargas, Caroline McMahon, Chiara Macor, Ciro Pasquale, Areti Bermperi, Evgenia Kourampa, Marivic Fabiculcana, Julie Ann Zerudo, Vivien Mendoza, Stewart Fuller, Claire Glemas, Sharon Baker, Greta Lyons, Marina Bishop, Siobhan Coleman, Naomi Thomas, Vince Mlilo, Edward Stanton, Rachel Michel, Julie Philips, Heidi Rice, Lucie Garner, Francesca Rosa, Saji Victor, Julie Zamikula, Sue Mepham, Fatima Hajee, Juan Carlos Quijano-Campos, Laura Watson, Christopher Georgiou, Jieniean Worsley, Djamilla Shamtally-Amode, Ferishta Rahimi, Heather Jones, Isabel Cruz, Gayle Lindsay, Christian Sparke, Anna Chapman, Katie Keating-Fedders, Codie Fahey, Danielle Johnson, Lucy Worboys, Simone Hargreaves, Ashlea Bucke, Lindsay Carr, Jackie Hampshire, Tracy Richardson, Jenny Sharpe, Lynne Whitehead, Naval Vyse, Stephen Kelleher, Mary-Beth Sherwood, Vicki Hughes, Kim Giraud

Publikováno v: Clinical Trials (London, England)

The COVID-19 pandemic has resulted in unprecedented challenges for healthcare systems worldwide. It has also stimulated research in a wide range of areas including rapid diagnostics, novel therapeutics, use of technology to track patients and vaccine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba67af3a6d9801d10a4f972ba42b5ca9
https://doi.org/10.1177/17407745211024764