Zobrazeno 1 - 10
of 2 155
pro vyhledávání: '"Essential gene"'
Autor:
Pasi K. Korhonen, Tao Wang, Neil D. Young, Joseph J. Byrne, Tulio L. Campos, Bill C.H. Chang, Aya C. Taki, Robin B. Gasser
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1026-1035 (2024)
Advances in single cell technologies are allowing investigations of a wide range of biological processes and pathways in animals, such as the multicellular model organism Caenorhabditis elegans – a free-living nematode. However, there has been limi
Externí odkaz:
https://doaj.org/article/7ab010327aba4ea691e436fd01e2f0e5
Autor:
Yujiro Hirose, Daniel C. Zielinski, Saugat Poudel, Kevin Rychel, Jonathon L. Baker, Yoshihiro Toya, Masaya Yamaguchi, Almut Heinken, Ines Thiele, Shigetada Kawabata, Bernhard O. Palsson, Victor Nizet
Publikováno v:
mSystems, Vol 9, Iss 9 (2024)
ABSTRACT Streptococcus pyogenes is responsible for a range of diseases in humans contributing significantly to morbidity and mortality. Among more than 200 serotypes of S. pyogenes, serotype M1 strains hold the greatest clinical relevance due to thei
Externí odkaz:
https://doaj.org/article/370f8241006e4225bac7c0888054f2d2
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT Phages and bacteria have a long history of co-evolution. However, these dynamics of phage-host interactions are still largely unknown; identification of phage inhibitors that remodel host metabolism will provide valuable information for targ
Externí odkaz:
https://doaj.org/article/29dfbe9e7aae48699768f5ea7553d568
Autor:
Yulian Ding, Connor Denomy, Andrew Freywald, Yi Pan, Franco J. Vizeacoumar, Frederick S. Vizeacoumar, Fang-Xiang Wu
Publikováno v:
Cells, Vol 13, Iss 19, p 1653 (2024)
Generally, essential genes identified using shRNA and CRISPR are not always the same, raising questions about the choice between these two screening platforms. To address this, we systematically compared the performance of CRISPR and shRNA to identif
Externí odkaz:
https://doaj.org/article/b180dc4208774d579bca638ea32ec1e8
Autor:
Kotaro Ishii, Yusuke Kazama, Tomonari Hirano, Jeffrey A. Fawcett, Muneo Sato, Masami Yokota Hirai, Fujiko Sakai, Yuki Shirakawa, Sumie Ohbu, Tomoko Abe
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
Heavy-ion beam, a type of ionizing radiation, has been applied to plant breeding as a powerful mutagen and is a promising tool to induce large deletions and chromosomal rearrangements. The effectiveness of heavy-ion irradiation can be explained by li
Externí odkaz:
https://doaj.org/article/8f0c4c1841d94cd39706eb9e902c2857
Autor:
Annesha Sengupta, Anindita Bandyopadhyay, Debolina Sarkar, John I. Hendry, Max G. Schubert, Deng Liu, George M. Church, Costas D. Maranas, Himadri B. Pakrasi
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT Cyanobacteria are photosynthetic organisms that have garnered significant recognition as potential hosts for sustainable bioproduction. However, their complex regulatory networks pose significant challenges to major metabolic engineering eff
Externí odkaz:
https://doaj.org/article/5967109df3564918935e1b8fda0efbac
Publikováno v:
iMeta, Vol 3, Iss 1, Pp n/a-n/a (2024)
Abstract Over the past few decades, there has been a significant interest in the study of essential genes, which are crucial for the survival of an organism under specific environmental conditions and thus have practical applications in the fields of
Externí odkaz:
https://doaj.org/article/51c62d967c78433282fecd6ca1081081
Autor:
Yonita Yuliani, Azizah Fitriana Nurul Ilmi, Suthidee Petsong, Ajcharaporn Sawatpanich, Sunisa Chirakul, Tanittha Chatsuwan, Tanapat Palaga, Suwatchareeporn Rotcheewaphan
Publikováno v:
Antibiotics, Vol 13, Iss 6, p 483 (2024)
Background: The discovery of novel therapeutic agents, especially those targeting mycobacterial membrane protein large 3 (mmpL3), has shown promise. In this study, the CRISPR interference-Streptococcus thermophilus nuclease-deactivated Cas9 (CRISPRi-
Externí odkaz:
https://doaj.org/article/9a1c479fb4824cfb84ae375b38a59b35
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT It is uncertain whether PA1610|fabA is essential or dispensable for growth on LB-agar plates under aerobic conditions in Pseudomonas aeruginosa PAO1. To examine its essentiality, we disrupted fabA in the presence of a native promoter-control
Externí odkaz:
https://doaj.org/article/8561b3856cca4fd3a540e4a0e6ea3f8a
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.