Výsledky vyhledávání - "Esselink, MT"

Increased glycocalicin index and normal thrombopoietin levels in patients with idiopathic thrombocytopenic purpura with a decreased rate of platelet production

Autor: Houwerzijl, EJ, Louwes, H, Esselink, MT, Smit, JW, Vellenga, E, de Wolf, JTM

Publikováno v: Haematologica, 90(5), 710-711. FERRATA STORTI FOUNDATION

Platelet kinetic studies in idiopathic thrombocytopenic purpura (ITP) have shown that in a subgroup of patients a shortened mean platelet life (MPL) is associated with a decreased platelet production rate (PPR).(1) Other methods of studying certain a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::7d4349f617b82b7ba0a15eada5539e17
https://research.rug.nl/en/publications/1a99f2cb-9ab2-4c3f-99bf-bcfa4a283eac

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Differential effects of interleukin-3 and interleukin-1 on the proliferation and interleukin-6 protein secretion of acute myeloid leukemic cells; the involvement of ERK, p38 and STAT5

Autor: Birkenkamp, KU, Esselink, MT, Kruijer, W, Vellenga, E

Publikováno v: European cytokine network, 10(4), 479-490

In the present study we examined whether the p38 and extracellular signal-regulated kinase (ERK) signal transduction pathways are involved in the interleukin-3 (IL-3)- or interleukin-1 (IL-1)-mediated proliferation and cytokine production of acute my

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::16e42ed54fb11cf1e82376524c1cb89f
https://research.rug.nl/en/publications/fd22a055-5ae4-4d92-ba2f-96a248924e86

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Interleukin-15 differentially enhances the expression of interferon-gamma and interleukin-4 in activated human (CD4(+))T lymphocytes

Autor: Borger, P, Kauffman, HF, Postma, DS, Esselink, MT, Vellenga, E

Publikováno v: Immunology, 96(2), 207-214. Wiley-Blackwell

In this study interleukin (IL)-15 was examined for its ability to modulate the expression of interferon-gamma (IFN-gamma) and IL-4 in activated human T lymphocytes. The effect of IL-15 was compared with IL-2 and IL-7, cytokines all known to use the I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::eae43f48b991aee2cf67d276819960a0
https://research.rug.nl/en/publications/525e7bbe-23aa-48c2-add7-147cd797f89c

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beta-adrenoceptor-mediated inhibition of IFN-gamma, IL-3, and GM-CSF mRNA accumulation in activated human T lymphocytes is solely mediated by the beta(2)-adrenoceptor subtype

Autor: Borger, P, Hoekstra, Y, Esselink, MT, Postma, DS, Zaagsma, J, Vellenga, E, Kauffman, HF

Publikováno v: American Journal of Respiratory Cell and Molecular Biology, 19(3), 400-407. AMER THORACIC SOC

Cytokine gene expression in T lymphocytes is a strictly regulated process, involving both stimulatory and inhibitory signals. beta-Adrenoceptor (beta AR) agonists are widely used in the treatment of asthma and are able to induce an inhibitory signal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::ec322f9287b2222e4145eb0dd3decb71
https://research.rug.nl/en/publications/a1cf99d7-d1d8-4685-8373-c137355d85ea

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THE SPONTANEOUS EXPRESSION OF INTERLEUKIN-1-BETA AND INTERLEUKIN-6 IS ASSOCIATED WITH SPONTANEOUS EXPRESSION OF AP-1 AND NF-KAPPA-B TRANSCRIPTION FACTOR IN ACUTE MYELOBLASTIC-LEUKEMIA CELLS

Autor: DOKTER, WHA, TUYT, L, SIERDSEMA, SJ, ESSELINK, MT, VELLENGA, E

Publikováno v: Leukemia, 9(3), 425-432. Nature Publishing Group

The nature of the spontaneous expression of cytokines that is observed in blasts of some AML patients is unclear. We studied whether or not the spontaneous expression of IL-1 beta and IL-6 is due to an increased transcription rate of the cytokine gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::3d6c97b186370b5551011f6dec222d66
https://research.rug.nl/en/publications/b53684ac-c137-47ef-aea5-15e6a9b82aa5

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Divergent effects of IL-10 and IL-4 on the proliferation and growth factor secretion by acute myeloblastic leukemic cells

Autor: Tuyt, LML, Dokter, WHA, Esselink, MT, Vellenga, E

Publikováno v: European cytokine network, 6(4), 231-235

The effects of interleukin-10 (IL-10) and IL-4 were studied on the spontaneous and IL-1, IL-3, and Granulocyte-Colony Stimulating Factor (G-CSF) supported proliferation of acute myeloid leukemic cells, IL-10 inhibited the spontaneous proliferation in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::e48c1b02ac758ccfcfc365bbbaf9675f
https://research.rug.nl/en/publications/910d2688-db30-44fd-b407-eaa2340fee77

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EFFECT OF ULTRAFILTERABLE PLATINUM CONCENTRATION ON CISPLATIN AND CARBOPLATIN CYTOTOXICITY IN HUMAN TUMOR AND BONE-MARROW CELLS IN-VITRO

Autor: GUCHELAAR, HJ, DEVRIES, EGE, MEIJER, C, ESSELINK, MT, VELLENGA, E, UGES, DRA, MULDER, NH

Publikováno v: Pharmaceutical Research, 11(9), 1265-1269. SPRINGER/PLENUM PUBLISHERS

The importance of the ultrafilterable platinum (fPt) fraction of cisplatin (CDDP) and carboplatin (CBDCA) for cytotoxicity and myelotoxicity was studied in vitro. By incubating CDDP or CBDCA with fetal calf serum (FCS) various fractions of fPt were p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::fbd92acb7884c89499e1819235041e35
https://research.rug.nl/en/publications/27856391-2700-41fe-bf07-d4c52d70c38b

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INTERLEUKIN-4-MEDIATED INHIBITION OF C-FOS MESSENGER-RNA EXPRESSION - ROLE OF THE LIPOXYGENASE DIRECTED PATHWAY

Autor: DOKTER, WHA, SIERDSEMA, SJ, ESSELINK, MT, HALIE, MR, VELLENGA, E

Publikováno v: Leukemia, 8(7), 1181-1184. Nature Publishing Group

Interleukin-4 inhibits several monocyte functions like A23187-induced expression of cytokines and c-fos and c-jun protooncogene mRNA expression. In an attempt to elucidate the mechanism by which this inhibitive effect is mediated, we compared the eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::4f9ffa690889705d5cd2821826446b2e
https://research.rug.nl/en/publications/5ad59043-ccd8-48ee-b8ed-b1beedc620c9

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DIFFERENTIAL REGULATION OF M-CSF AND IL-6 GENE-EXPRESSION IN MONOCYTIC CELLS

Autor: DEWIT, H, ESSELINK, MT, HALIE, MR, VELLENGA, E

Publikováno v: British Journal of Haematology, 86(2), 259-264. Wiley

Using the human monocytic cell line Mono Mac 6 we studied the involvement of Ca2+, protein kinase A (PKA), and protein kinase C (PKC) dependent pathways in the regulation of M-CSF and IL-6 gene expression The results demonstrate that on activation wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::729b6d8e7c7fe345ba51bde12cc4cb54
https://research.rug.nl/en/publications/4ea1ea30-ed45-4c8d-aefe-0b58472c4c4a

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INTERLEUKIN-4 MESSENGER-RNA AND PROTEIN IN ACTIVATED HUMAN T-CELLS ARE ENHANCED BY INTERLEUKIN-7

Autor: DOKTER, WHA, SIERDSEMA, SJ, ESSELINK, MT, HALIE, MR, VELLENGA, E

Publikováno v: Experimental Hematology, 22(1), 74-79. ELSEVIER SCIENCE INC

We studied the effect of the stroma-derived cytokine interleukin-7 (IL-7) on the expression of IL-4 in human T cells at mRNA and protein level. The results demonstrate that IL-7 did not induce IL-4 mRNA in resting T cells. However, concanavalin A (co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::29a57a8bc0c793b057930c50fc8d0559
https://research.rug.nl/en/publications/aab7e82a-0fed-4a90-a9e7-10b037272791

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