Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Essam Eldin A. Osman"'
Autor:
Mai M. Shaalan, Essam Eldin A. Osman, Yasmeen M. Attia, Olfat A. Hammam, Riham F. George, Bassem H. Naguib
Publikováno v:
ACS Omega, Vol 9, Iss 35, Pp 37310-37329 (2024)
Externí odkaz:
https://doaj.org/article/28b76977d2614297b14c55913c9a2f5b
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-22 (2023)
Abstract To exploit the advantageous properties of approved drugs to hasten anticancer drug discovery, we designed and synthesized a series of fluoroquinolone (FQ) analogs via functionalization of the acid hydrazides of moxifloxacin, ofloxacin, and c
Externí odkaz:
https://doaj.org/article/0be48dc5dceb439eae7cb8c4c30bb271
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 176-188 (2017)
New target compounds were designed as inhibitors of tubulin polymerization relying on using two types of ring B models (cyclohexenone and indazole) to replace the central ring in colchicine. Different functional groups (R1) were attached to manipulat
Externí odkaz:
https://doaj.org/article/c2d6dbbe02d64e02b6baa7b47f4a60f3
Autor:
Joyeeta Roy, Armita Kyani, Maha Hanafi, Yibin Xu, John Takyi-Williams, Duxin Sun, Essam Eldin A. Osman, Nouri Neamati
Publikováno v:
Journal of Medicinal Chemistry. 66:1990-2019
Autor:
Mengchao Cui, Seung Jae Hyeon, Ahmed A. Elbatrawy, Yun Kyung Kim, Hoon Ryu, Seung Hyeo Choi, Ghilsoo Nam, Sungsu Lim, Nan Yue, Essam Eldin A. Osman
Publikováno v:
ACS Sensors. 6:2281-2289
Tau aggregation is believed to have a strong association with the level of cognitive deficits in Alzheimer's disease (AD). Thus, optical brain imaging of tau aggregates has recently gained substantial attention as a promising tool for the early diagn
Publikováno v:
Journal of medicinal chemistry. 65(4)
Analysis of the SARS-CoV-2 sequence revealed a multibasic furin cleavage site at the S1/S2 boundary of the spike protein distinguishing this virus from SARS-CoV. Furin, the best-characterized member of the mammalian proprotein convertases, is an ubiq
Autor:
Laurent Treamblu, Hesham A.M. Gomaa, Dina H. Elnaggar, Ola F. Abou-Ghadir, Ashraf M. Mohamed, Essam Eldin A. Osman, Mostafa H. Abdelrahman, Bahaa G.M. Youssif
Publikováno v:
European Journal of Medicinal Chemistry. 177:1-11
Cannabinoids as THC and the CB1 allosteric modulator CBD were reported to have antiproliferative activities with no reports for other CB1 allosteric modulators as the 5-chloroindole-2-carboxamide derivatives and their furan congeners. Based on the an
Autor:
Alaa M. Hayallah, Bahaa G.M. Youssif, Mohamed Abdel-Aziz, Essam Eldin A. Osman, Mohamed Hisham
Publikováno v:
European Journal of Medicinal Chemistry. 176:117-128
A series of novel xanthine/NO donor hybrids containing 1,3,8-trisubstituted or 1,8-disubstituted xanthine derivatives were designed and synthesized. The synthesized compounds were tested in a cell viability assay using human mammary gland epithelial
Publikováno v:
Bioorganic chemistry. 104
Six series based on barbituric acid 5a-e, 10a-d; thiobarbituric acid 6a-e, 11a-d and 1,3-dimethylbarbituric acid 7a-e, 12a-d were prepared and screened for their in vitro PARP1 inhibition. They revealed promising inhibition at nanomolar level especia
Publikováno v:
ACS Infectious Diseases
Novel beta-coronavirus SARS-CoV-2 is the pathogenic agent responsible for coronavirus disease-2019 (COVID-19), a globally pandemic infectious disease. Due to its high virulence and the absence of immunity among the general population, SARS-CoV-2 has