Zobrazeno 1 - 1
of 1
pro vyhledávání: '"Esra Özdelen"'
Autor:
Gurol Tuncman, Qiong Cao, Umut Ozcan, Laurie H. Glimcher, Ann-Hwee Lee, Cem Z. Görgün, Gökhan S. Hotamisligil, Neal N. Iwakoshi, Erkan Yilmaz, Esra Özdelen
Publikováno v:
Science. 306:457-461
Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms are poorly understood. Using cell culture and mouse models, we show that obesity causes endoplasmic reticulum (ER) stress. This stress in turn leads to suppressi