Peptidoglycan NlpC/P60 peptidases in bacterial physiology and host interactions

Autor: Griffin, Matthew E., Klupt, Steven, Espinosa, Juliel, Hang, Howard C.

Publikováno v: In Cell Chemical Biology 18 May 2023 30(5):436-456

Enterococcus peptidoglycan remodeling promotes checkpoint inhibitor cancer immunotherapy

Autor: Griffin, Matthew E, Espinosa, Juliel, Becker, Jessica L, Luo, Ji-Dung, Carroll, Thomas S, Jha, Jyoti K, Fanger, Gary R, Hang, Howard C

Publikováno v: Science (New York, N.Y.), vol 373, iss 6558

The antitumor efficacy of cancer immunotherapy can correlate with the presence of certain bacterial species within the gut microbiome. However, many of the molecular mechanisms that influence host response to immunotherapy remain elusive. In this stu

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EnterococcusNlpC/p60 Peptidoglycan Hydrolase SagA Localizes to Sites of Cell Division and Requires Only a Catalytic Dyad for Protease Activity

Autor: Espinosa, Juliel, Lin, Ti-Yu, Estrella, Yadyvic, Kim, Byungchul, Molina, Henrik, Hang, Howard C.

Publikováno v: Biochemistry; November 2020, Vol. 59 Issue: 46 p4470-4480, 11p

Lytic bacteriophages facilitate antibiotic sensitization of Enterococcus faecium .

Autor: Canfield GS; Division of Infectious Diseases, University of Colorado School of Medicine, Aurora, Colorado, USA.; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA., Chatterjee A; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA., Espinosa J; Laboratory of Chemical Biology and Microbial Pathogenesis, The Rockefeller University, New York, New York, USA., Mangalea MR; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA., Sheriff EK; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA., Keidan M; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA., McBride SW; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA., McCollister BD; Division of Infectious Diseases, University of Colorado School of Medicine, Aurora, Colorado, USA., Hang HC; Laboratory of Chemical Biology and Microbial Pathogenesis, The Rockefeller University, New York, New York, USA.; Departments of Immunology & Microbiology and Chemistry, Scripps Research, La Jolla, California, USA., Duerkop BA; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA breck.duerkop@cuanschutz.edu.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2023 May 01; Vol. 65 (5). Date of Electronic Publication: 2021 Mar 01.