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Publikováno v:
Current Opinion in Genetics & Development. 19:424-436
Recent evidence suggests that dynamic three-dimensional genomic interactions in the nucleus exert critical roles in regulated gene expression. Here, we review a series of recent paradigm-shifting experiments that highlight the existence of specific g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::069ae513b128572f3fa277be87526575
https://doi.org/10.1016/j.gde.2009.07.005
https://doi.org/10.1016/j.gde.2009.07.005
Autor:
Ivan Garcia-Bassets, Qidong Hu, Kasey R. Hutt, Esperanza Nunez, Maria Dafne Cardamone, Xiang-Dong Fu, Christopher K. Glass, Michael G. Rosenfeld, Young-Soo Kwon, Kenneth A. Ohgi, David W. Rose
Publikováno v:
Cell. 132:996-1010
While the transcriptional machinery has been extensively dissected at the molecular level, little is known about regulation of chromosomal organization in the three-dimensional space of the nucleus to achieve integrated transcriptional responses to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983da313253aea7bdc960ebf268eb836
https://doi.org/10.1016/j.cell.2008.01.051
https://doi.org/10.1016/j.cell.2008.01.051
Autor:
Michael G. Rosenfeld, Thorsten Cramer, Kasey R. Hutt, Xiaoyan Zhu, Esperanza Nunez, Victoria V. Lunyak, Lluis Montoliu, Ángel García-Díaz, Yun C. Yung, Bong-Gun Ju, Christopher K. Glass, Kenneth A. Ohgi, R. Roy, Gratien G. Prefontaine
Publikováno v:
Science. 317:248-251
The temporal and spatial regulation of gene expression in mammalian development is linked to the establishment of functional chromatin domains. Here, we report that tissue-specific transcription of a retrotransposon repeat in the murine growth hormon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462842c9c963b1cbc25f73f4a6f9e907
https://doi.org/10.1126/science.1140871
https://doi.org/10.1126/science.1140871
Autor:
Daria Merkurjev, Wenbo Li, Xiaoyuan Song, Qi Ma, Soohwan Oh, Christopher K. Glass, Dimple Notani, Bogdan Tanasa, Hong-Sook Kim, Michael G. Rosenfeld, Jie Zhang, Aaron Yun Chen, Kenneth A. Ohgi, Esperanza Nunez
Publikováno v:
Nature. 498(7455)
The functional importance of gene enhancers in regulated gene expression is well established. In addition to widespread transcription of long non-coding RNAs (lncRNAs) in mammalian cells, bidirectional ncRNAs are transcribed on enhancers, and are thu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b980485de61f83c0c24962b8353165
https://pubmed.ncbi.nlm.nih.gov/23877407
https://pubmed.ncbi.nlm.nih.gov/23877407
Autor:
Liuqing Yang, Qidong Hu, Wen Liu, Esperanza Nunez, Michael G. Rosenfeld, Wenbo Li, Chunru Lin
Publikováno v:
The FASEB Journal. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b6c9d9f84368d2e0442a0c54392149d
https://doi.org/10.1096/fasebj.26.1_supplement.333.5
https://doi.org/10.1096/fasebj.26.1_supplement.333.5
Autor:
Michael G. Rosenfeld, Maria Dafne Cardamone, Kasey R. Hutt, Kenneth A. Ohgi, Ivan Garcia-Bassets, Esperanza Nunez, Christopher K. Glass, Young-Soo Kwon, Xiang-Dong Fu, David W. Rose, Qidong Hu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 105(49)
Although the role of liganded nuclear receptors in mediating coactivator/corepressor exchange is well-established, little is known about the potential regulation of chromosomal organization in the 3-dimensional space of the nucleus in achieving integ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5597c6dab2516006bb3c519ba7d8d404
https://pubmed.ncbi.nlm.nih.gov/25197091
https://pubmed.ncbi.nlm.nih.gov/25197091
Autor:
Yu-Tsueng Liu, Dennis A. Carson, Qing Lu, Chunrun Lin, Jessica Wang-Rodriguez, Kimberly Christensen, Tracy M. Downs, Esperanza Nunez
Publikováno v:
Nucleic Acids Research
Studies of gene fusions in solid tumors are not as extensive as in hematological malignancies due to several technical and analytical problems associated with tumor heterogeneity. Nevertheless, there is a growing interest in the role of fusion genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca48d622894fcc718b1337408106369b
https://pubmed.ncbi.nlm.nih.gov/18794177
https://pubmed.ncbi.nlm.nih.gov/18794177
Autor:
Esperanza Nunez, Maria Dafne Cardamone, Ivan Garcia-Bassets, Kenneth A. Ohgi, Qidong Hu, Young-Soo Kwon, Kasey R. Hutt, Xiang-Dong Fu, Michael G. Rosenfeld, David W. Rose, Christopher K. Glass
Publikováno v:
Cell. 134(1)
While the transcriptional machinery has been extensively dissected at the molecular level, little is known about regulation of chromosomal organization in the three-dimensional space of the nucleus to achieve integrated transcriptional responses to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5099fe52fcd2211adcf76ce683a63578
Publikováno v:
Eugin Destici
Despite the long-standing recognition of distinct subnuclear architectural features and the recent discovery of noncoding RNAs (ncRNAs), their potential interacting roles in gene regulation remain elusive. We have found that two ncRNAs, TUG1 and NEAT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46994d6a1c1af2bff37ac11308bef9b0
https://doi.org/10.1158/1538-7445.prca2012-ia3
https://doi.org/10.1158/1538-7445.prca2012-ia3