Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Esperanza M. Algarín"'
Autor:
Esperanza M. Algarín, Dalia Quwaider, Francisco J. Campos-Laborie, Andrea Díaz-Tejedor, Pedro Mogollón, Elena Vuelta, Montserrat Martín-Sánchez, Laura San-Segundo, Lorena González-Méndez, Norma C. Gutiérrez, Ramón García-Sanz, Teresa Paíno, Javier De Las Rivas, Enrique M. Ocio, Mercedes Garayoa
Publikováno v:
Cells, Vol 10, Iss 3, p 559 (2021)
BH3-mimetics targeting anti-apoptotic proteins such as MCL-1 (S63845) or BCL-2 (venetoclax) are currently being evaluated as effective therapies for the treatment of multiple myeloma (MM). Interleukin 6, produced by mesenchymal stromal cells (MSCs),
Externí odkaz:
https://doaj.org/article/7bd7f27b907643eda8b4ac2b546d5f0a
Autor:
Esperanza M Algarín, Andrea Díaz-Tejedor, Pedro Mogollón, Susana Hernández-García, Luis A. Corchete, Laura San-Segundo, Montserrat Martín-Sánchez, Lorena González-Méndez, Marie Schoumacher, Sebastien Banquet, Laurence Kraus-Berthier, Ioana Kloos, Alix Derreal, Ensar Halilovic, Heiko Maacke, Norma C. Gutiérrez, María-Victoria Mateos, Teresa Paíno, Mercedes Garayoa, Enrique M. Ocio
Publikováno v:
Haematologica, Vol 105, Iss 3 (2020)
Externí odkaz:
https://doaj.org/article/512f9175196b4277b36f9d7dcf905aba
Autor:
Enrique M. Ocio, Mercedes Garayoa, María-Victoria Maetos, Norma C. Gutiérrez, Luis A. Corchete, Carlos Ortiz-de-Solorzano, David Corbacho, Montserrat Martín-Sánchez, Esperanza M. Algarín, Ana-Alicia López-Iglesias, Susana Hernández-García, Laura San-Segundo, Lorena González-Méndez, Antonio Garcia-Gomez, Teresa Paíno
Purpose: PIM kinases are a family of serine/threonine kinases recently proposed as therapeutic targets in oncology. In the present work, we have investigated the effects of the novel pan-PIM kinase inhibitor, PIM447, on myeloma cells and myeloma-asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c4e842dd6ae86666bf855ccba83042
https://doi.org/10.1158/1078-0432.c.6526520.v1
https://doi.org/10.1158/1078-0432.c.6526520.v1
Autor:
Enrique M. Ocio, Mercedes Garayoa, María-Victoria Maetos, Norma C. Gutiérrez, Luis A. Corchete, Carlos Ortiz-de-Solorzano, David Corbacho, Montserrat Martín-Sánchez, Esperanza M. Algarín, Ana-Alicia López-Iglesias, Susana Hernández-García, Laura San-Segundo, Lorena González-Méndez, Antonio Garcia-Gomez, Teresa Paíno
Supplementary Figure 1. Evaluation of apoptosis and cell cycle in MM cell lines after PIM447 treatment. -Supplementary Figure 2. PIM447 very strongly synergizes with different antimyeloma agents in the RPMI-8226 cell line. -Supplementary Figure 3. Ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c679e19e1bf938a3b2b16c8ee51060
https://doi.org/10.1158/1078-0432.22467035
https://doi.org/10.1158/1078-0432.22467035
Autor:
Lorena González-Méndez, Javier De Las Rivas, Elena Vuelta, Norma C. Gutiérrez, Andrea Díaz-Tejedor, Esperanza M Algarín, Pedro Mogollón, Laura San-Segundo, Dalia Quwaider, Montserrat Martín-Sánchez, Teresa Paíno, Ramón García-Sanz, Enrique M. Ocio, Francisco J. Campos-Laborie, Mercedes Garayoa
Publikováno v:
Cells
Volume 10
Issue 3
Cells, Vol 10, Iss 559, p 559 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cells . 2021 Mar 4;10(3):559
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Volume 10
Issue 3
Cells, Vol 10, Iss 559, p 559 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cells . 2021 Mar 4;10(3):559
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
© 2021 by the authors.
BH3-mimetics targeting anti-apoptotic proteins such as MCL-1 (S63845) or BCL-2 (venetoclax) are currently being evaluated as effective therapies for the treatment of multiple myeloma (MM). Interleukin 6, produced by mesen
BH3-mimetics targeting anti-apoptotic proteins such as MCL-1 (S63845) or BCL-2 (venetoclax) are currently being evaluated as effective therapies for the treatment of multiple myeloma (MM). Interleukin 6, produced by mesen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23def009e1085f10043ec1f555b25c2d
Autor:
Mercedes Garayoa, Norma C. Gutiérrez, Maria-Victoria Mateos, Luis A. Corchete, Enrique M. Ocio, Laura San-Segundo, Susana Hernández-García, Esperanza M Algarín, Montserrat Martín-Sánchez, Pedro Mogollón, Lorena González-Méndez, Teresa Paíno, Andrea Díaz-Tejedor
Publikováno v:
Cancers (Basel) . 2020 Sep 24;12(10):2743
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Cancers
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cancers, Vol 12, Iss 2743, p 2743 (2020)
Volume 12
Issue 10
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Cancers
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cancers, Vol 12, Iss 2743, p 2743 (2020)
Volume 12
Issue 10
© 2020 by the authors.
[Background]: Proviral Insertion site for Moloney murine leukemia virus (PIM) kinases are overexpressed in hematologic malignancies, including multiple myeloma. Previous preclinical data from our group demonstrated the an
[Background]: Proviral Insertion site for Moloney murine leukemia virus (PIM) kinases are overexpressed in hematologic malignancies, including multiple myeloma. Previous preclinical data from our group demonstrated the an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3704d9a4aa0ea1386471118477b5714
http://hdl.handle.net/10902/21517
http://hdl.handle.net/10902/21517
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
[Introduction]: Kinesin spindle protein (KSP) is indispensable for the proper separation of spindle poles during mitosis. Importantly, this protein is expressed only in cells undergoing cell division and hence represents an appealing target for the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6051e257e3c1563991a71805095071ec
http://hdl.handle.net/10261/222823
http://hdl.handle.net/10261/222823
Autor:
Laura San-Segundo, Esperanza M Algarín, Mercedes Garayoa, Lorena González-Méndez, Andrea Díaz-Tejedor, Teresa Paíno, Norma C. Gutiérrez, Luis A. Corchete, Brian Tunquist, Irena Misiewicz-Krzeminska, Enrique M. Ocio, Montserrat Martín-Sánchez, Elena Díaz-Rodríguez, Susana Hernández-García, Maria-Victoria Mateos, Pedro Mogollón, Ana-Alicia López-Iglesias
Publikováno v:
GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname
Haematologica
instname
Haematologica
[EN]Kinesin spindle protein inhibition is known to be an effective therapeutic approach in several malignancies. Filanesib (ARRY-520), an inhibitor of this protein, has demonstrated activity in heavily pre-treated multiple myeloma patients. The aim o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52beab60992207b0f566e28abca67ca
https://doi.org/10.3324/haematol.2017.168666
https://doi.org/10.3324/haematol.2017.168666
Autor:
Pedro Mogollón, Lorena González-Méndez, Andrea Díaz-Tejedor, Montserrat Martín-Sánchez, Esperanza M Algarín, Enrique M. Ocio, Ensar Halilovic, Norma C. Gutiérrez, Sébastien Banquet, Maria-Victoria Mateos, Laura San-Segundo, Teresa Paíno, Mercedes Garayoa, Susana Hernández-García, Heiko Maacke, Alix Derreal, Laurence Kraus-Berthier, Luis A. Corchete, Ioana Kloos, Marie Schoumacher
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Haematologica . 2020 Mar;105(3):e116-e120
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
instname
Haematologica . 2020 Mar;105(3):e116-e120
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
This work was supported by the Spanish ISCIII-FIS and FEDER Funds (PI 15/00067 and PI 15/02156) and the Regional Health Council of Castilla y León (GRS 1604/A/17). EMA was supported by a grant from the Regional Education Council of Castilla y Leó
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d44ea51fc5752fed67abba7f22e3a9
https://pubmed.ncbi.nlm.nih.gov/31320555
https://pubmed.ncbi.nlm.nih.gov/31320555
Autor:
Esperanza M Algarín, Teresa Paíno, Andrea Díaz-Tejedor, Pedro Mogollón, Mercedes Garayoa, Enrique M. Ocio
Publikováno v:
Cells . 2019 Nov 13;8(11):1432
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Cells
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Cells
A high priority problem in multiple myeloma (MM) management is the development of resistance to administered therapies, with most myeloma patients facing successively shorter periods of response and relapse. Herewith, we review the current knowledge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6ca53a2ac3cbc989e14af57dbfe270
http://hdl.handle.net/10902/21519
http://hdl.handle.net/10902/21519