Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Esperamicin A1"'
Publikováno v:
Synlett. 2000:0658-0662
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba65dad8dda90f7cf434fbe7c4189ea0
https://doi.org/10.1055/s-2000-6602
https://doi.org/10.1055/s-2000-6602
Publikováno v:
Tetrahedron Letters. 40:291-294
The conversion of keto ester 1, obtained in either enantiomeric form from (−)-quinic acid, to its corresponding enol silyl ether 4 was examined as the first step to construct the allyl trisulfide unit found in esperamicin A1. Under different condit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fbf1d3c4fe85a2c520052502280ee48
https://doi.org/10.1016/s0040-4039(98)02399-5
https://doi.org/10.1016/s0040-4039(98)02399-5
Publikováno v:
Tetrahedron Letters. 40:295-298
The MOM protected keto alcohol 7 was successfully converted to the silyl enol ether 4 by reaction with BSA. Reaction of this intermediate with dioxirane led to formation of allylic alcohol 10 . Lactone 15 was obtained by reaction of tosylate 14 with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a33114559b460d3586849274445a2df
https://doi.org/10.1016/s0040-4039(98)02400-9
https://doi.org/10.1016/s0040-4039(98)02400-9
Publikováno v:
Tetrahedron. 53:14369-14380
The monosaccharide component (α and β-anomer) of the E Ring of calicheamicin γ1I and esperamicin A1 has been synthetized by an efficient and improved stereoselective procedure starting from methyl 2-deoxy-α- and β-D-ribopyranoside. The synthetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8043398a268fe73ce9aa87471147900
https://doi.org/10.1016/s0040-4020(97)00921-6
https://doi.org/10.1016/s0040-4020(97)00921-6
Publikováno v:
Nucleic Acids Research. 25:1836-1845
Bleomycin (BLM) binding and chemistry are apparently sensitive to differences in nucleic acid conformation and could conceivably be developed as a probe for sequence-dependent elements of conformation. We report on the development of a new methodolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64733277037176fece89e797b949257
https://doi.org/10.1093/nar/25.9.1836
https://doi.org/10.1093/nar/25.9.1836
Publikováno v:
Pure and Applied Chemistry. 68:601-604
Two strategies for the construction of the calicheamicin/esperamicin core structure are presented. The first is based upon the 2.3-Wittig ring contraction of a 13- membered macrocycle 3 (X = CH2 or NCaMe). The aza 2,3-Wittig rearrangement of 3 (X = N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::713453c8d15000c6c89d9173f3298144
https://doi.org/10.1351/pac199668030601
https://doi.org/10.1351/pac199668030601
Publikováno v:
Journal of the American Chemical Society. 116:9733-9738
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bba11111a2262130b167aa4dc1cd0c3
https://doi.org/10.1021/ja00100a044
https://doi.org/10.1021/ja00100a044
Autor:
William R. Roush, Darin J. Gustin
Publikováno v:
Tetrahedron Letters. 35:4931-4934
A stereochemically general synthesis of methyl 2,4,6-trideoxy-4-methylthio-α-D-ribo-pyranoside ( 1b ), the thio sugar isolated from esperamicin, is described. The synthesis involves the neighboring group assisted delivery of a sulfur nucleophile to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54061b8346090c80aa274468526b83ce
https://doi.org/10.1016/s0040-4039(00)73285-0
https://doi.org/10.1016/s0040-4039(00)73285-0
Autor:
John F. Kadow, Nada Zein, William C. Rose, Stephen W. Mamber, Wyle Solomon, Daniel Richard Marshall, Gregory Roth
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:711-714
A series of electronically and sterically altered enediyne cores, based on esperamicin, were prepared using a cobalt mediated cyclization strategy in an attempt to improve the antitumor activity of this class of compounds. The biological activity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::615a9f5cbb363c7caa53949a3adf17df
https://doi.org/10.1016/s0960-894x(01)80185-2
https://doi.org/10.1016/s0960-894x(01)80185-2
Publikováno v:
Journal of Biological Chemistry. 269:4144-4151
DNA damage in HeLa nuclei and isolated nucleosome core particles has been examined for several members of the enediyne family of antitumor antibiotics: calicheamicin gamma 1I (CAL), esperamicin A1 (ESP A1), esperamicin C (ESP C), and neocarzinostatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a83f604fef3fe6047519a6d62db95d1
https://doi.org/10.1016/s0021-9258(17)41755-8
https://doi.org/10.1016/s0021-9258(17)41755-8