Zobrazeno 1 - 10
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pro vyhledávání: '"Esperamicin"'
Akademický článek
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Akademický článek
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Publikováno v:
Journal of the American Chemical Society. 132:967-979
A variety of fragmentations and rearrangements can follow Bergman cyclization in enediynes equipped with acetal rings mimicking the carbohydrate moiety of natural enediyne antibiotics of the esperamicine and calchiamicine families. In the first step
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e2ffbabc8e4b41696919314496cf868
https://doi.org/10.1021/ja905100u
https://doi.org/10.1021/ja905100u
Publikováno v:
Nucleic Acids Research. 25:1836-1845
Bleomycin (BLM) binding and chemistry are apparently sensitive to differences in nucleic acid conformation and could conceivably be developed as a probe for sequence-dependent elements of conformation. We report on the development of a new methodolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64733277037176fece89e797b949257
https://doi.org/10.1093/nar/25.9.1836
https://doi.org/10.1093/nar/25.9.1836
Publikováno v:
Pure and Applied Chemistry. 68:601-604
Two strategies for the construction of the calicheamicin/esperamicin core structure are presented. The first is based upon the 2.3-Wittig ring contraction of a 13- membered macrocycle 3 (X = CH2 or NCaMe). The aza 2,3-Wittig rearrangement of 3 (X = N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::713453c8d15000c6c89d9173f3298144
https://doi.org/10.1351/pac199668030601
https://doi.org/10.1351/pac199668030601
Autor:
George A. Ellestad, Girija Krishnamurthy, Egidio Giorgio, Katsunori Tanaka, Carlo Rosini, Nina Berova, Weidong Ding, Keith Pitts
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:5072-5079
The aglycon, or so-called 'warhead' portion, of several potent 10-membered ring enediyne antitumor antibiotics contain dienonecarbamate and enediyne chromophores in an unusual bicyclic ring structure in which these two subunits are essentially orthog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62fac3c0a2674b22db3fb345b25a85ad
https://doi.org/10.1016/j.bmc.2005.04.007
https://doi.org/10.1016/j.bmc.2005.04.007
Autor:
William R. Roush, Darin J. Gustin
Publikováno v:
Tetrahedron Letters. 35:4931-4934
A stereochemically general synthesis of methyl 2,4,6-trideoxy-4-methylthio-α-D-ribo-pyranoside ( 1b ), the thio sugar isolated from esperamicin, is described. The synthesis involves the neighboring group assisted delivery of a sulfur nucleophile to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54061b8346090c80aa274468526b83ce
https://doi.org/10.1016/s0040-4039(00)73285-0
https://doi.org/10.1016/s0040-4039(00)73285-0
Autor:
John F. Kadow, Nada Zein, William C. Rose, Stephen W. Mamber, Wyle Solomon, Daniel Richard Marshall, Gregory Roth
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:711-714
A series of electronically and sterically altered enediyne cores, based on esperamicin, were prepared using a cobalt mediated cyclization strategy in an attempt to improve the antitumor activity of this class of compounds. The biological activity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::615a9f5cbb363c7caa53949a3adf17df
https://doi.org/10.1016/s0960-894x(01)80185-2
https://doi.org/10.1016/s0960-894x(01)80185-2
Publikováno v:
Journal of Biological Chemistry. 269:4144-4151
DNA damage in HeLa nuclei and isolated nucleosome core particles has been examined for several members of the enediyne family of antitumor antibiotics: calicheamicin gamma 1I (CAL), esperamicin A1 (ESP A1), esperamicin C (ESP C), and neocarzinostatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a83f604fef3fe6047519a6d62db95d1
https://doi.org/10.1016/s0021-9258(17)41755-8
https://doi.org/10.1016/s0021-9258(17)41755-8
Publikováno v:
Journal of the American Chemical Society. 116:15-29
A solvated model for the DNA-esperamicin complex has been constructed and shown to be thermodynamically stable over a 300-ps molecular dynamics simulation. The dynamical model is consistent with all of the available experimental data. The model has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e15f7fd290c88d9b78a8c63af37dd9a
https://doi.org/10.1021/ja00080a003
https://doi.org/10.1021/ja00080a003