Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Espen, Molden"'
Autor:
Hasan Çağın Lenk, Elise Koch, Kevin S. O’Connell, Robert Løvsletten Smith, Ibrahim A. Akkouh, Srdjan Djurovic, Ole A. Andreassen, Espen Molden
Publikováno v:
Human Genomics, Vol 18, Iss 1, Pp 1-9 (2024)
Abstract Background Treatment resistant schizophrenia (TRS) is broadly defined as inadequate response to adequate treatment and is associated with a substantial increase in disease burden. Clozapine is the only approved treatment for TRS, showing sup
Externí odkaz:
https://doaj.org/article/369f22af251e4c118addb20133152a72
Autor:
Marta H. Hernandez, Jacqueline M. Cohen, Karoline H. Skåra, Thea K. Grindstad, Yunsung Lee, Per Magnus, Pål R. Njølstad, Ole A. Andreassen, Elizabeth C. Corfield, Alexandra Havdahl, Espen Molden, Kari Furu, Maria C. Magnus, Alvaro Hernaez
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109285- (2024)
Summary: Low birth weight raises neonatal risks and lifelong health issues and is linked to maternal medication use during pregnancy. We examined data from the Norwegian Mother, Father, and Child Cohort Study and the Medical Birth Registry of Norway,
Externí odkaz:
https://doaj.org/article/e30fa6344ada4cb6aaa0e9e53d4984dc
Autor:
Robert Løvsletten Smith, Birgit M. Wollmann, Elisabet Størset, Hasan Çağın Lenk, Kevin S. O'Connell, Marianne Kringen Kristiansen, Magnus Ingelman‐Sundberg, Espen Molden
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 2, Pp n/a-n/a (2024)
Abstract Cytochrome P450 2D6 (CYP2D6) is important for metabolism of 20%–25% of all clinically used drugs. Many known genetic variants contribute to the large interindividual variability in CYP2D6 metabolism, but much is still unexplained. We recen
Externí odkaz:
https://doaj.org/article/bc583d3f16e243a881eff9ea3dbfb57a
Autor:
Pari Faraj, Elisabet Størset, Kristine Hole, Godfrey Smith, Espen Molden, Erik Sveberg Dietrichs
Publikováno v:
EBioMedicine, Vol 95, Iss , Pp 104779- (2023)
Summary: Background: For a decade, patients have been advised against using high citalopram- and escitalopram-doses due to risk for ventricular arrhythmia and cardiac arrest. Still, these drugs are widely used to treat depression and anxiety especial
Externí odkaz:
https://doaj.org/article/e9dd8f7480494aac94df61a7749140a7
Autor:
Hasan Çağın Lenk, Robert Løvsletten Smith, Kevin S. O'Connell, Marin M. Jukić, Marianne Kristiansen Kringen, Ole A. Andreassen, Magnus Ingelman‐Sundberg, Espen Molden
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 1, Pp 62-72 (2023)
Abstract Clinical response of clozapine is closely associated with serum concentration. Although tobacco smoking is the key environmental factor underlying interindividual variability in clozapine metabolism, recent genome‐wide studies suggest that
Externí odkaz:
https://doaj.org/article/b404641d026a4bb681d473f000373fe3
Autor:
Line Skute Bråten, Magnus Ingelman‐Sundberg, Marin M. Jukic, Espen Molden, Marianne Kristiansen Kringen
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 9, Pp 2135-2145 (2022)
Abstract Sertraline is a commonly used SSRI antidepressant drug, metabolized by CYP2C19 and CYP2B6, that exhibits a substantial interindividual variation in clinical response, of which only a part can be attributed to known genetic variants. In the c
Externí odkaz:
https://doaj.org/article/65875f5235c64f31969d93433786b3a6
Publikováno v:
BMC Geriatrics, Vol 22, Iss 1, Pp 1-8 (2022)
Abstract Background In older patients with polypharmacy and multiple comorbidities, even low grades of statin-associated muscle symptoms may have clinical implications. The aim of this study was therefore to investigate the potential associations bet
Externí odkaz:
https://doaj.org/article/2ede51c200ea4fb6a527fa203186bf64
Autor:
Lisbeth Damlien Nymoen, Trude Eline Flatebø, Tron Anders Moger, Erik Øie, Espen Molden, Kirsten Kilvik Viktil
Publikováno v:
PLoS ONE, Vol 17, Iss 9 (2022)
Introduction The main objective of this study was to investigate whether systematic medication review conducted by clinical pharmacists can impact clinical outcomes and post-discharge outcomes for patients admitted to the emergency department. Method
Externí odkaz:
https://doaj.org/article/ac70373ce242405487cacfdc0fa53b0f
Autor:
Ron HN van Schaik, Vangelis G Manolopoulos, Ann K Daly, Mikko Niemi, Branka Zukic, George P Patrinos, Dragan Primorac, Jesse J Swen, Magnus Ingelman-Sundberg, Tiffany Morris, Espen Molden, Daniel Müller, Sonja Pavlovic, Stefan Russmann, Marc Ansari, Linda M Henricks, Wout van den Broek, Francesco Florindi, Nada Bozina, Demet Akin, Lona Christrup, Adrian Llerena, Cilla Sipeky, Sanja Stankovic
Publikováno v:
Pharmacogenomics, 24(5), 243-246. Future Medicine Ltd.
On 8–9 November 2022, the European Society of Pharmacogenomics and Personalised Therapy organized its sixth biennial congress, in Belgrade, Serbia (congress website: www.sspt.rs ). The congress aimed to address the current status and future perspec
Autor:
Birgit M. Wollmann, Elisabet Størset, Marianne Kristiansen Kringen, Espen Molden, Robert L. Smith
Publikováno v:
European Journal of Clinical Pharmacology. 79:523-531
Purpose Poor metabolizers (PMs) of the highly polymorphic enzyme CYP2D6 are usually at high risk of adverse effects during standard recommended dosing of CYP2D6-metabolized drugs. We studied if the metabolism of solanidine, a dietary compound found i