A small molecule mitigates hearing loss in a mouse model of Usher syndrome III.

Autor: Alagramam KN; Otolaryngology Head and Neck Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.; Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, USA.; Neurosciences, Case Western Reserve University, Cleveland, Ohio, USA., Gopal SR; Otolaryngology Head and Neck Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA., Geng R; Otolaryngology Head and Neck Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA., Chen DH; Otolaryngology Head and Neck Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA., Nemet I; Pharmacology and Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, Cleveland, Ohio, USA., Lee R; Pharmacology and Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, Cleveland, Ohio, USA., Tian G; Pharmacology and Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, Cleveland, Ohio, USA., Miyagi M; Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio, USA., Malagu KF; BioFocus, a Charles River company, Chesterford Research Park, Saffron Walden, UK., Lock CJ; BioFocus, a Charles River company, Chesterford Research Park, Saffron Walden, UK., Esmieu WR; BioFocus, a Charles River company, Chesterford Research Park, Saffron Walden, UK., Owens AP; BioFocus, a Charles River company, Chesterford Research Park, Saffron Walden, UK., Lindsay NA; BioFocus, a Charles River company, Chesterford Research Park, Saffron Walden, UK., Ouwehand K; Charles River Nederland BV, Leiden, the Netherlands., Albertus F; Charles River Nederland BV, Leiden, the Netherlands., Fischer DF; Charles River Nederland BV, Leiden, the Netherlands., Bürli RW; BioFocus, a Charles River company, Chesterford Research Park, Saffron Walden, UK., MacLeod AM; BioFocus, a Charles River company, Chesterford Research Park, Saffron Walden, UK., Harte WE; Office of Translation and Innovation, Case Western Reserve University, Cleveland, Ohio, USA., Palczewski K; Pharmacology and Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, Cleveland, Ohio, USA., Imanishi Y; Pharmacology and Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, Cleveland, Ohio, USA.

Publikováno v: Nature chemical biology [Nat Chem Biol] 2016 Jun; Vol. 12 (6), pp. 444-51. Date of Electronic Publication: 2016 Apr 25.