Výsledky vyhledávání - "Esmeralda Woestenenk"

Akademický článek

Probing contacts of inhibitor locked in transition states in the catalytic triad of DENV2 type serine protease and its mutants by 1H, 19F and 15 N NMR spectroscopy

Autor: Peter Agback, Esmeralda Woestenenk, Tatiana Agback

Publikováno v: BMC Molecular and Cell Biology, Vol 21, Iss 1, Pp 1-15 (2020)

Abstract Background Detailed structural knowledge of enzyme-inhibitor complexes trapped in intermediate state is the key for a fundamental understanding of reaction mechanisms taking place in enzymes and is indispensable as a structure-guided drug de

Externí odkaz: https://doaj.org/article/cd2f2af7a0814709812ab5bea8083cb8

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Probing contacts of inhibitor locked in transition states in the catalytic triad of DENV2 type serine protease and its mutants by 1H, 19F and 15 N NMR spectroscopy

Autor: Esmeralda Woestenenk, Tatiana Agback, Peter Agback

Publikováno v: BMC Molecular and Cell Biology, Vol 21, Iss 1, Pp 1-15 (2020)
BMC Molecular and Cell Biology

Background Detailed structural knowledge of enzyme-inhibitor complexes trapped in intermediate state is the key for a fundamental understanding of reaction mechanisms taking place in enzymes and is indispensable as a structure-guided drug design tool

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::954dcf325dd0fafe110faca414686f57
https://doi.org/10.1186/s12860-020-00283-0

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Backbone nuclear magnetic resonance assignment of human deoxyuridine 5′-triphosphate nucleotidohydrolase (dUTPase)

Autor: Johan Isaksson, Tatiana Agback, Christer Sahlberg, Esmeralda Woestenenk

Publikováno v: Biomolecular NMR Assignments. 8:81-84

Nuclear-associated deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) is an enzyme that hydrolyses deoxyuridine 5'-triphosphate (dUTP) to the monophosphate, thereby controlling the dUTP levels of the organism, which is essential for survival.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b531ac5a4c0a274df35071fa3af728
https://doi.org/10.1007/s12104-013-9457-7

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Design and synthesis of potent hydroxyethylamine (HEA) BACE-1 inhibitors carrying prime side 4,5,6,7-tetrahydrobenzazole and 4,5,6,7-tetrahydropyridinoazole templates

Autor: Jimmy Lindberg, Cathrine Åhgren, Esmeralda Woestenenk, Dean Derbyshire, Erik Lindström, Oscar Belda, Kristina Wikström, Neera Borkakoti, Elizabeth Hamelink, Genadiy Kalayanov, Christian Sund, Anders Eneroth, Lotta Vrang

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 22:6721-6727

A set of low molecular weight compounds containing a hydroxyethylamine (HEA) core structure with different prime side alkyl substituted 4,5,6,7-tetrahydrobenzazoles and one 4,5,6,7-tetrahydropyridinoazole was synthesized. Striking differences were ob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5bc6d82f37c6afc8a6e8d033e858dec
https://doi.org/10.1016/j.bmcl.2012.08.097

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Natural Disulfide Bond-disrupted Mutants of AVR4 of the Tomato Pathogen Cladosporium fulvum Are Sensitive to Proteolysis, Circumvent Cf-4-mediated Resistance, but Retain Their Chitin Binding Ability

Autor: N. Westerink, Sjef Boeren, Jacques Vervoort, Pierre J. G. M. de Wit, Esmeralda Woestenenk, Harrold A. van den Burg, Matthieu H. A. J. Joosten, R. Roth, Kees-Jan Francoijs

Publikováno v: Journal of Biological Chemistry 278 (2003) 30
Journal of Biological Chemistry, 278(30), 27340-27346

The extracellular AVR4 elicitor of the pathogenic fungus Cladosporium fulvum induces defense responses in the tomato genotype Cf-4. Here, the four disulfide bonds of AVR4 were identified as Cys-11-41, Cys-21-27, Cys-35-80, and Cys-57-72 by partial re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6deb0b95c71268e4a4b7e4a3468b2ecd
https://doi.org/10.1074/jbc.m212196200

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