Zobrazeno 1 - 10 of 21 pro vyhledávání: '"Esmee Koedoot"'
1
Akademický článek
Organoids as a biomarker for personalized treatment in metastatic colorectal cancer: drug screen optimization and correlation with patient response
Autor: Lidwien P. Smabers, Emerens Wensink, Carla S. Verissimo, Esmee Koedoot, Katerina-Chara Pitsa, Maarten A. Huismans, Celia Higuera Barón, Mayke Doorn, Liselot B. Valkenburg-van Iersel, Geert A. Cirkel, Anneta Brousali, René Overmeer, Miriam Koopman, Manon N. Braat, Bas Penning de Vries, Sjoerd G. Elias, Robert G. Vries, Onno Kranenburg, Sylvia F. Boj, Jeanine M. Roodhart
Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-16 (2024)
Abstract Background The inability to predict treatment response of colorectal cancer patients results in unnecessary toxicity, decreased efficacy and survival. Response testing on patient-derived organoids (PDOs) is a promising biomarker for treatmen
Externí odkaz: https://doaj.org/article/42108938a8624e94af5a5620f30c1743
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2
Akademický článek
Splicing factors control triple-negative breast cancer cell mitosis through SUN2 interaction and sororin intron retention
Autor: Esmee Koedoot, Eline van Steijn, Marjolein Vermeer, Román González-Prieto, Alfred C. O. Vertegaal, John W. M. Martens, Sylvia E. Le Dévédec, Bob van de Water
Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-17 (2021)
Abstract Background Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited therapeutic opportunities. Recently, splicing factors have gained attention as potential targets for cancer treatment. Here we systematica
Externí odkaz: https://doaj.org/article/965c99b87fb3412fb4c7057176e1ddb5
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3
Akademický článek
Differential reprogramming of breast cancer subtypes in 3D cultures and implications for sensitivity to targeted therapy
Autor: Esmee Koedoot, Liesanne Wolters, Marcel Smid, Peter Stoilov, Gerhard A. Burger, Bram Herpers, Kuan Yan, Leo S. Price, John W. M. Martens, Sylvia E. Le Dévédec, Bob van de Water
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Screening for effective candidate drugs for breast cancer has shifted from two-dimensional (2D) to three-dimensional (3D) cultures. Here we systematically compared the transcriptomes of these different culture conditions by RNAseq of 14 BC c
Externí odkaz: https://doaj.org/article/57418be9999441f5885dc1b1785fe4d6
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4
Akademický článek
Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes
Autor: Esmee Koedoot, Michiel Fokkelman, Vasiliki-Maria Rogkoti, Marcel Smid, Iris van de Sandt, Hans de Bont, Chantal Pont, Janna E. Klip, Steven Wink, Mieke A. Timmermans, Erik A. C. Wiemer, Peter Stoilov, John A. Foekens, Sylvia E. Le Dévédec, John W. M. Martens, Bob van de Water
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Triple-negative breast cancers (TNBC) have enhanced migratory behaviour. Here, the authors perform a phenotypic imaging-based RNAi screen to identify several genes associated with regulation of migratory phenotypes and show that one of the regulators
Externí odkaz: https://doaj.org/article/720606fcf5f54cc0ae38a7db6f491bec
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5
Abstract 157: Patient in the lab: Down-scaling patient-derived organoid screening for diagnostic purposes
Autor: Esmee Koedoot, Inez van Weersch, Gakuro Harada, Masahiko Watanabe, Hamdy Warda, Hideaki Kyan, Yasmine Abouleila, Takahiko Kumagai, Yuichi Hikichi, René Overmeer, Jeanine Roodhart, Kiyotaka Matsuno, Carla Verissimo, Sylvia F. Boj
Publikováno v: Cancer Research. 83:157-157
Colorectal cancer (CRC) is the third leading cause of cancer and cancer-related death. A large fraction of the CRC patients diagnosed with de novo metastatic disease do not benefit from standard of care and experience substantial side effects. Theref
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24410ba3b26fd9bbc48ac426abfc0969
https://doi.org/10.1158/1538-7445.am2023-157
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6
Abstract 151: Optimization of screening conditions using patient-derived organoids for diagnostic purposes
Autor: Carla S. Verissimo, Lidwien Smabers, Emerens Wensink, Esmee Koedoot, Katerina-Chara Pitsa, Mayke Doorn, Inez van Weersch, Hamdy Warda, Celia Higuera Barón, Gerben ten Hag, Robert G. Vries, Jeanine Roodhart, Sylvia F. Boj
Publikováno v: Cancer Research. 83:151-151
Patient-derived organoids (PDOs) are increasingly adopted in preclinical research. PDOs, or HUB Organoids®, are directly established from patient tissue, faithfully recapitulate patient disease, and effectively bridge the gap between the lab and the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::399ba0f6083351364e483c03f3ef745a
https://doi.org/10.1158/1538-7445.am2023-151
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7
Migration rather than proliferation transcriptomic signatures are strongly associated with breast cancer patient survival
Autor: Eytan Ruppin, Nishanth Ulhas Nair, Joo Sang Lee, Michiel Fokkelman, Sridhar Hannenhalli, Benjamin G. Neel, Bob van de Water, Vasiliki-Maria Rogkoti, Richard Marcotte, Isaac Meilijson, Sylvia E. Le Dévédec, Avinash Das, Chiaro G. de Jong, Esmee Koedoot
Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports, 9, 10989
The efficacy of prospective cancer treatments is routinely estimated by in vitro cell-line proliferation screens. However, it is unclear whether tumor aggressiveness and patient survival are influenced more by the proliferative or the migratory prope
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b90107213a59a3a3a97921d57bb922
http://link.springer.com/article/10.1038/s41598-019-47440-w
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9
Differential reprogramming of breast cancer subtypes in 3D cultures and implications for sensitivity to targeted therapy
Autor: John W.M. Martens, Sylvia E. Le Dévédec, Gerhard A. Burger, Leo S. Price, Liesanne Wolters, Marcel Smid, Peter Stoilov, Bram Herpers, Kuan Yan, Bob van de Water, Esmee Koedoot
Publikováno v: Scientific Reports, 11, 7529
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, 11(1):7259. Nature Publishing Group
Screening for effective candidate drugs for breast cancer has shifted from two-dimensional (2D) to three-dimensional (3D) cultures. Here we systematically compared the transcriptomes of these different culture conditions by RNAseq of 14 BC cell lines
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb9daee7c16d87843e377180eabd4c3
https://hdl.handle.net/1887/3166006
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10
Splicing factors control triple-negative breast cancer cell mitosis through SUN2 interaction and sororin intron retention
Autor: Eline van Steijn, Esmee Koedoot, Marjolein Vermeer, Alfred C.O. Vertegaal, Román González-Prieto, John W.M. Martens, Bob van de Water, Sylvia E. Le Dévédec
Publikováno v: Journal of Experimental & Clinical Cancer Research, 40. Springer Science and Business Media LLC
Journal of Experimental and Clinical Cancer Research, 40(1). BMC
Journal of Experimental & Clinical Cancer Research, 40(1):82. BioMed Central Ltd.
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-17 (2021)
Background Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited therapeutic opportunities. Recently, splicing factors have gained attention as potential targets for cancer treatment. Here we systematically evalu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738ae893f8d5ab122e39b6a7d3e78fa3
http://hdl.handle.net/1887/3204454
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