Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Eshwar Meduri"'
Autor:
Raquel S. Pereira, Rahul Kumar, Alessia Cais, Lara Paulini, Alisa Kahler, Jimena Bravo, Valentina R. Minciacchi, Theresa Krack, Eric Kowarz, Costanza Zanetti, Parimala Sonika Godavarthy, Fabian Hoeller, Pablo Llavona, Tabea Stark, Georg Tascher, Daniel Nowak, Eshwar Meduri, Brian J. P. Huntly, Christian Münch, Francesco Pampaloni, Rolf Marschalek, Daniela S. Krause
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Haematopoietic stem cells (HSC) reside in the bone marrow microenvironment (BMM), where they respond to extracellular calcium [eCa2+] via the G-protein coupled calcium-sensing receptor (CaSR). Here we show that a calcium gradient exists in t
Externí odkaz:
https://doaj.org/article/00699074cde14bba837f1807407edcf5
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105622- (2022)
Summary: Several studies have documented aberrant RNA editing patterns across multiple tumors across large patient cohorts from The Cancer Genome Atlas (TCGA). However, studies on understanding the role of RNA editing in acute myeloid leukemia (AML)
Externí odkaz:
https://doaj.org/article/0c7677ca02cc4eab950752ae31ce4cbc
Autor:
Alexander W Drong, George Nicholson, Asa K Hedman, Eshwar Meduri, Elin Grundberg, Kerrin S Small, So-Youn Shin, Jordana T Bell, Fredrik Karpe, Nicole Soranzo, Tim D Spector, Mark I McCarthy, Panos Deloukas, Mattias Rantalainen, Cecilia M Lindgren, MolPAGE Consortia
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55923 (2013)
Genetic variants that associate with DNA methylation at CpG sites (methylation quantitative trait loci, meQTLs) offer a potential biological mechanism of action for disease associated SNPs. We investigated whether meQTLs exist in abdominal subcutaneo
Externí odkaz:
https://doaj.org/article/649fa27bf9c84420ad067f48835c3e70
Publikováno v:
PLoS Genetics, Vol 6, Iss 1, p e1000819 (2010)
Intron number varies considerably among genomes, but despite their fundamental importance, the mutational mechanisms and evolutionary processes underlying the expansion of intron number remain unknown. Here we show that Drosophila, in contrast to mos
Externí odkaz:
https://doaj.org/article/b08dbf52e5174a50832df109a15a206e
Autor:
Oliver M. Dovey, Pedro Madrigal, Paolo Gallipoli, George S. Vassiliou, Haiyang Yun, Cameron S. Osborne, Shuchi Agrawal-Singh, Annalisa Mupo, Shabana Vohra, David Lara-Astiaso, Aracely Castillo-Venzor, Faisal Basheer, Sarah J. Horton, Brian J. P. Huntly, Ludovica Marando, Malgorzata Gozdecka, Eshwar Meduri, Carsten Müller-Tidow, Daniel Sasca, George Giotopoulos, Xiaonan Wang, Nisha Narayan
Publikováno v:
Nature Genetics. 53:1443-1455
Altered transcription is a cardinal feature of acute myeloid leukemia (AML); however, exactly how mutations synergize to remodel the epigenetic landscape and rewire three-dimensional DNA topology is unknown. Here, we apply an integrated genomic appro
Autor:
Viral Shah, George Giotopoulos, Hikari Osaki, Markus Meyerhöfer, Eshwar Meduri, Benedict Schubert, Haiyang Yun, Sarah J Horton, Shuchi Agrawal-Singh, Patricia S Haehnel, Faisal Basheer, Dave Lugo, Michael WM Kühn, Borhane Guezguez, Matthias Theobald, Thomas Kindler, Paolo Gallipoli, Rab K Prinjha, Brian JP Huntly, Daniel Sasca
Initial clinical trials with drugs targeting epigenetic modulators - such as bromodomain and extraterminal (BET) inhibitors - demonstrate modest results in acute myeloid leukemia (AML). The main reason for this involves an increased transcriptional p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99d2692ba4e1ae6a1d89938b2c1a17d9
https://doi.org/10.1101/2022.09.14.507850
https://doi.org/10.1101/2022.09.14.507850
Autor:
Shuchi Agrawal Singh, Jaana Bagri, George Giotopoulos, Eshwar Meduri, Shubha Anad, Sarah J. Horton, Daniel Sasca, Haiyang Yun, Anthony Whetton, Brian James Patrick Huntly
Publikováno v:
Blood. 140:720-721
Autor:
Bryann Pardieu, Justine Pasanisi, Frank Ling, Reinaldo Dal Bello, Justine Penneroux, Angela Su, Romane Joudinaud, Laureen Chat, Hsin Chieh Wu, Matthieu Duchmann, Gaetano Sodaro, Clémentine Chauvel, Florence A. Castelli, Loic Vasseur, Kim Pacchiardi, Yannis Belloucif, Marie-Charlotte Laiguillon, Eshwar Meduri, Camille Vaganay, Gabriela Alexe, Jeannig Berrou, Chaima Benaksas, Antoine Forget, Thorsten Braun, Claude Gardin, Emmanuel Raffoux, Emmanuelle Clappier, Lionel Adès, Hugues de Thé, François Fenaille, Brian J. Huntly, Kimberly Stegmaier, Hervé Dombret, Nina Fenouille, Camille Lobry, Alexandre Puissant, Raphael Itzykson
Publikováno v:
Leukemia
Leukemia, 2022, 36 (6), pp.1585-1595. ⟨10.1038/s41375-022-01573-6⟩
Leukemia, 2022, 36 (6), pp.1585-1595. ⟨10.1038/s41375-022-01573-6⟩
By querying metabolic pathways associated with leukemic stemness and survival in multiple AML datasets, we nominated SLC7A11 encoding the xCT cystine importer as a putative AML dependency. Genetic and chemical inhibition of SLC7A11 impaired the viabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8490e809959cf8bced0c21513b0a94f9
https://hal.science/hal-04053984
https://hal.science/hal-04053984
Autor:
Malgorzata Gozdecka, Eshwar Meduri, Milena Mazan, Konstantinos Tzelepis, Monika Dudek, Andrew J. Knights, Mercedes Pardo, Lu Yu, Jyoti S. Choudhary, Emmanouil Metzakopian, Vivek Iyer, Haiyang Yun, Naomi Park, Ignacio Varela, Ruben Bautista, Grace Collord, Oliver Dovey, Dimitrios A. Garyfallos, Etienne De Braekeleer, Saki Kondo, Jonathan Cooper, Berthold Göttgens, Lars Bullinger, Paul A. Northcott, David Adams, George S. Vassiliou, Brian J. P. Huntly
Publikováno v:
Nature Genetics. 54:1062-1062
Autor:
George Giotopoulos, Shabana Vohra, Carsten Müller-Tidow, Faisal Basheer, Annalisa Mupo, Daniel Sasca, Paolo Gallipoli, Eshwar Meduri, Sarah J. Horton, Ludovica Marando, Malgorzata Gozdecka, Oliver M. Dovey, Xiaonan Wang, George S. Vassiliou, Shuchi Agrawal-Singh, Cameron S. Osborne, Aracely Castillo-Venzor, Brian J. P. Huntly, Haiyang Yun
Altered transcription is a cardinal feature of acute myeloid leukemia (AML), however, exactly how mutations synergize to remodel the epigenetic landscape and rewire 3-Dimensional (3-D) DNA topology is unknown. Here we apply an integrated genomic appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c296f929ce2ad4d8f3c2ad117276b1a
https://doi.org/10.1101/2020.03.20.000059
https://doi.org/10.1101/2020.03.20.000059