Výsledky vyhledávání

Akademický článek

Mesenchymal Stem Cells Promote Pancreatic Tumor Growth by Inducing Alternative Polarization of Macrophages

Autor: Esha Mathew, Arthur L. Brannon, AnnaChiara Del Vecchio, Paloma E. Garcia, Morgan K. Penny, Kevin T. Kane, Alekya Vinta, Ronald J. Buckanovich, Marina Pasca di Magliano

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 18, Iss 3, Pp 142-151 (2016)

Pancreatic cancer is characterized by an extensive desmoplastic stroma, the functional relevance of which is poorly understood. Activated fibroblasts are a prevalent component of the stroma, and traditionally, these cells have been considered as a ho

Externí odkaz: https://doaj.org/article/2302dae203264d8ea457f1a9f45934cc

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Akademický článek

Epithelial-Myeloid cell crosstalk regulates acinar cell plasticity and pancreatic remodeling in mice

Autor: Yaqing Zhang, Wei Yan, Esha Mathew, Kevin T Kane, Arthur Brannon III, Maeva Adoumie, Alekya Vinta, Howard C Crawford, Marina Pasca di Magliano

Publikováno v: eLife, Vol 6 (2017)

Dedifferentiation of acini to duct-like cells occurs during the physiologic damage response in the pancreas, but this process can be co-opted by oncogenic Kras to drive carcinogenesis. Myeloid cells infiltrate the pancreas during the onset of pancrea

Externí odkaz: https://doaj.org/article/18440f62d47549e7a0383006b185ab9a

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Akademický článek

Dosage-Dependent Regulation of Pancreatic Cancer Growth and Angiogenesis by Hedgehog Signaling

Autor: Esha Mathew, Yaqing Zhang, Alexander M. Holtz, Kevin T. Kane, Jane Y. Song, Benjamin L. Allen, Marina Pasca di Magliano

Publikováno v: Cell Reports, Vol 9, Iss 2, Pp 484-494 (2014)

Pancreatic cancer, a hypovascular and highly desmoplastic cancer, is characterized by tumor expression of Hedgehog (HH) ligands that signal to fibroblasts in the surrounding stroma that in turn promote tumor survival and growth. However, the mechanis

Externí odkaz: https://doaj.org/article/e9be95f6d8944e78a2b57779e9af30eb

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Data from CD4+ T Lymphocyte Ablation Prevents Pancreatic Carcinogenesis in Mice

Autor: Marina Pasca di Magliano, Robert H. Vonderheide, Theodore H. Welling, Rebecca A. Evans, Meredith A. Collins, Shanshan Wan, Filip Bednar, Esha Mathew, Wei Yan, Yaqing Zhang

Pancreatic cancer, one of the deadliest human malignancies, is associated with oncogenic Kras and is most commonly preceded by precursor lesions known as pancreatic intraepithelial neoplasias (PanIN). PanIN formation is accompanied by the establishme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77987c6afc3695ff044a5d3af9bc4ccb
https://doi.org/10.1158/2326-6066.c.6548512.v1

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