Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Esha Gauba"'
Publikováno v:
Neurobiology of Disease, Vol 121, Iss , Pp 138-147 (2019)
Mitochondrial dysfunction is pivotal in inducing synaptic injury and neuronal stress in Alzheimer's disease (AD). Mitochondrial F1Fo ATP synthase deregulation is a hallmark mitochondrial defect leading to oxidative phosphorylation (OXPHOS) failure in
Externí odkaz:
https://doaj.org/article/3773cd372f084558bf43e753d0fe277c
Autor:
Simon J. Beck, Lan Guo, Aarron Phensy, Jing Tian, Lu Wang, Neha Tandon, Esha Gauba, Lin Lu, Juan M. Pascual, Sven Kroener, Heng Du
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
F1FO ATP synthase is a critical enzyme for the maintenance of mitochondrial function. Here the authors demonstrate that loss of the F1FO-ATP synthase subunit OSCP and the interaction of OSCP with Aβ peptide in Alzheimer’s disease patients and mous
Externí odkaz:
https://doaj.org/article/2355879c4d3140d08af5450ae819ae13
Autor:
Lin Lu, Lan Guo, Esha Gauba, Jing Tian, Lu Wang, Neha Tandon, Malini Shankar, Simon J Beck, Yifeng Du, Heng Du
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144068 (2015)
Alzheimer's disease (AD) is heterogeneous and multifactorial neurological disorder; and the risk factors of AD still remain elusive. Recent studies have highlighted the role of vascular factors in promoting the progression of AD and have suggested th
Externí odkaz:
https://doaj.org/article/d124e010242448b8b4c78a2784b153ef
Autor:
Joy Q He, Amira Latif-Hernandez, Makoto Suematsu, Miles H. Linde, Esha Gauba, Ling Liu, Ravi Majeti, Katrin I. Andreasson, Peter K. Moon, Yuki Sugiura, Joshua D. Rabinowitz, Irving L. Weissman, Amit Joshi, Aarooran Sivakumaran Durairaj, Amanda J. Rubin, Melanie R. McReynolds, Qian Wang, Paras S. Minhas, Daria Mochly-Rosen, Congcong Wang, Frank M. Longo
Publikováno v:
Nature. 590:122-128
Ageing is characterized by the development of persistent pro-inflammatory responses that contribute to atherosclerosis, metabolic syndrome, cancer and frailty1-3. The ageing brain is also vulnerable to inflammation, as demonstrated by the high preval
Autor:
Aarron Phensy, Jing Tian, Esha Gauba, Kathy L. Lindquist, Heng Du, Karen A. Lindquist, Lan Guo, Dania Bairuty, Sven Kroener
Publikováno v:
J Neurosci
Redox dysregulation and oxidative stress are final common pathways in the pathophysiology of a variety of psychiatric disorders, including schizophrenia. Oxidative stress causes dysfunction of GABAergic parvalbumin (PV)-positive interneurons (PVI), w
Autor:
Christopher Driskill, Lan Guo, Esha Gauba, Qi Wang, Tripta Rughwani, Kun Jia, Jing Tian, Sven Kroener, Heng Du, Shaomei Sui, Chunxiao Yu
Publikováno v:
Neurobiol Aging
Background Oligomycin-sensitivity conferring protein (OSCP) is a critical subunit of mitochondrial F1Fo ATP synthase. OSCP dysfunction has been observed in Alzheimer’s disease (AD) brains and a mouse model with AD-like brain amyloidosis (5xFAD mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7d8121d3aaaefff80968070eb5cd5c
https://doi.org/10.21203/rs.3.rs-25903/v1
https://doi.org/10.21203/rs.3.rs-25903/v1
Autor:
Karen A. Lindquist, Aarron Phensy, Jing Tian, Esha Gauba, Kathy L. Lindquist, Lan Guo, Sven Kroener, Dania Bairuty, Heng Du
Redox dysregulation and oxidative stress are final common pathways in the pathophysiology of a variety of psychiatric disorders, including schizophrenia. Oxidative stress causes dysfunction of GABAergic parvalbumin-positive interneurons (PVI), which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f601495eba526536c4332cf59ad569
https://doi.org/10.1101/2020.04.15.043570
https://doi.org/10.1101/2020.04.15.043570
Autor:
Sven Kroener, Jeffrey M. Zigman, Lan Guo, Christopher Driskill, Esha Gauba, Qi Wang, Heng Du, Aarron Phensy, Shaomei Sui, Jing Tian, Russell H. Swerdlow
Publikováno v:
Science translational medicine. 11(505)
Hippocampal lesions are a defining pathology of Alzheimer's disease (AD). However, the molecular mechanisms that underlie hippocampal synaptic injury in AD have not been fully elucidated. Current therapeutic efforts for AD treatment are not effective
Publikováno v:
Neurobiology of Disease, Vol 121, Iss, Pp 138-147 (2019)
Mitochondrial dysfunction is pivotal in inducing synaptic injury and neuronal stress in Alzheimer's disease (AD). Mitochondrial F1Fo ATP synthase deregulation is a hallmark mitochondrial defect leading to oxidative phosphorylation (OXPHOS) failure in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7eff3ba8edb2a4b36e44f2bf622c8b7
https://europepmc.org/articles/PMC6250052/
https://europepmc.org/articles/PMC6250052/
Recent studies have highlighted the role of mitochondria in dendritic protrusion growth and plasticity. However, the detailed mechanisms that mitochondria regulate dendritic filopodia morphogenesis remain elusive. Cyclophilin D (CypD, gene name: Ppif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::879accd20f38be59b8509fa6edd3efd1
https://europepmc.org/articles/PMC6107423/
https://europepmc.org/articles/PMC6107423/