Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Eseroline"'
Autor:
Johannes B. Zimmermann, Nadine Pinder, Thomas Bruckner, Monika Lehmann, Johann Motsch, Thorsten Brenner, Torsten Hoppe-Tichy, Stefanie Swoboda, Markus A. Weigand, Stefan Hofer
Publikováno v:
Trials, Vol 18, Iss 1, Pp 1-10 (2017)
Abstract Background Severe sepsis and septic shock remain a major challenge, even in modern intensive care. In Germany, about 68,000 patients die annually because of septic diseases, characterized by a complex systemic inflammatory response. Causal t
Externí odkaz:
https://doaj.org/article/9c52de4af1584b79a50ce359dd1cbf1d
Akademický článek
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Publikováno v:
Mini Reviews in Medicinal Chemistry. 13:456-466
Morphinans have a storied history in medicinal chemistry as pain management drugs but have received attention as modulators of cholinergic signaling for the treatment of Alzheimer’s Disease (AD). Galantamine is a reversible, competitive acetylcholi
Akademický článek
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Publikováno v:
Journal of Chromatographic Science. 49:265-271
MEKC was used for the separation of nine acetylcholinesterase inhibitors (AChEIs). AChEIs are an important group of drug compounds that are used medicinally to treat Alzheimer's disease and Myasthenia Gravis. At the time of the experiment, this is th
Autor:
Stefan Höfer, Thorsten Brenner, Nadine Pinder, Johannes Zimmermann, Torsten Hoppe-Tichy, Ute Gubbe, Stefanie Swoboda, Markus A. Weigand
Publikováno v:
Clinical Chemistry and Laboratory Medicine (CCLM). 53
BACKGROUND Physostigmine, commonly used as an antidote in anticholinergic poisoning, is reported to have additional pharmacological effects, such as activation of the cholinergic anti-inflammatory pathway in sepsis models. Due to the narrow therapeut
Publikováno v:
Tetrahedron. 61:9147-9156
A new flexible approach to hexahydropyrrolo[2,3- b ]indole system via the [3,3]-sigmatropic rearrangement of 1-(2′-methoxycarbonyl- N -methylvinylamino)skatole, culminating in the synthesis of (±)-desoxyeseroline, is described.
Publikováno v:
Journal of Chromatography B. 784:323-329
Physostigmine, an anticholinergic drug, and its metabolite eseroline can be quantitated by high-performance liquid chromatography (HPLC) with photodiode-array detection. After addition of the structurally related internal standard (-)-N-methylphysost
Autor:
J Rupreht, B Dworacek
Publikováno v:
International Congress Series. 1242:87-93
In the 1860s, the extract of the Calabar bean or Esere nut was studied as a poison but was also introduced into ophthalmology as an antagonist for atropine. Kleinwachter of Prague described it in 1864 as a successful and specific antidote for atropin
Autor:
Jure Stojan, Marko Goličnik
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry. 17:279-285
The kinetic rate constants for interaction of (-)-eseroline-(3aS-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo-[2,3-b]indol-5-ol with electric eel acetylcholinesterase (EC 3.1.1.7, acetylcholine acetylhydrolase) were measured at a low substrat