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Akademický článek

Derivatives of Esculentin-1 Peptides as Promising Candidates for Fighting Infections from Escherichia coli O157:H7

Autor: Raffaella Scotti, Bruno Casciaro, Annarita Stringaro, Fabrizio Morgia, Maria Luisa Mangoni, Roberta Gabbianelli

Publikováno v: Antibiotics, Vol 11, Iss 5, p 656 (2022)

New strategies are needed to fight the emergence of multidrug-resistant bacteria caused by an overuse of antibiotics in medical and veterinary fields. Due to the importance of biofilms in clinical infections, antibiofilm peptides have a great potenti

Externí odkaz: https://doaj.org/article/52cc385efbbc4ac48021c7f7dcdc3ea8

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Linearized esculentin-2EM shows pH dependent antibacterial activity with an alkaline optimum

Autor: David A. Phoenix, Jaipaul Singh, L.H.G. Morton, Timothy J. Snape, Erum Malik, Sarah R. Dennison, Frederick Harris

Publikováno v: Molecular and Cellular Biochemistry

Here the hypothesis that linearized esculentin 2EM (E2EM-lin) from Glandirana emeljanovi possesses pH dependent activity is investigated. The peptide showed weak activity against Gram-negative bacteria (MLCs ≥ 75.0 μM) but potent efficacy towards

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf056196cc0368705362b5b7cba0a45d
http://europepmc.org/articles/PMC8382640

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Beneficial actions of esculentin-2CHa(GA30) on high sucrose-induced oxidative stress in Drosophila melanogaster

Autor: Adeola O. Adedara, Opeolu O. Ojo, Oluwabukola M. Farodoye, Omolola A Adesanoye, Amos O. Abolaji, Ayodele A. Falobi

Publikováno v: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 157

Hyperglycaemia-induced oxidative stress plays a critical role in the development of diabetes and its complications. This study investigated actions of esculentin-2CHa(GA30) on high sucrose-induced oxidative stress in adult Drosophila melanogaster. Ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f1a06544cbbd54dc446d953e42a177
https://pubmed.ncbi.nlm.nih.gov/34656695

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Akademický článek

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Membrane perturbing activities and structural properties of the frog-skin derived peptide Esculentin-1a(1-21)NH2 and its Diastereomer Esc(1-21)-1c: Correlation with their antipseudomonal and cytotoxic activity

Autor: Burkhard Bechinger, Vincenzo Luca, Maria Luisa Mangoni, Anirban Bhunia, Anirban Ghosh, Bruno Casciaro, Lorenzo Stella, Annalisa Bortolotti, Floriana Cappiello, Maria Rosa Loffredo, Nicole Harmouche

Publikováno v: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1859:2327-2339

Antimicrobial peptides (AMPs) represent new alternatives to cope with the increasing number of multi-drug resistant microbial infections. Recently, a derivative of the frog-skin AMP esculentin-1a, Esc(1-21), was found to rapidly kill both the plankto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e71b2ef996441e7009d583a219fbea3
https://doi.org/10.1016/j.bbamem.2017.09.009

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Immunomodulatory and anti-diabetic actions of a structurally-modified analogue of esculentin-2CHa isolated from the skin secretion of the frog, lithobates chiricahuensis (ranidae)

Autor: Monica Sen, Falobi Ayodele Abiodun, Opeolu O. Ojo, Wendy Amy Ofosu, Falana Ayokunle Benjamin, Lesley A. Smyth

Publikováno v: Endocrine Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e1868b2eea5f90acb4ae98dcdb5a365
https://doi.org/10.1530/endoabs.70.aep252

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Akademický článek

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Inhibition of MDR/MRSA Bacterial Biofilms by the Antimicrobial Peptides Esculaentin 1-A and OH-CATH-30 Monitored by a Thermal Sensor System in Real-Time

Autor: Julia Assmann, Jan K. Kotthaus, Gerald Urban, Tobias Wieland, Helena Gmoser

Publikováno v: 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII).

In the present work, we showcase a reusable miniaturized thermal sensor based on sinusoidal excitation for continuous monitoring of biofilms over several days. The sensor measurement system is able to steadily monitor biofilm formation with very low

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::158f72d3bc8af004f4eecf35d1f4939a
https://doi.org/10.1109/transducers.2019.8808589

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