Výsledky vyhledávání - "Escherichia coli Proteins/chemistry"

Structure of the mini-RNA-guided endonuclease CRISPR-Cas12j3

Autor: Guillermo Montoya, Tillmann Pape, Simon Erlendsson, Stefano Stella, Anders Fuglsang, Piero Temperini, Nicholas Sofos, Arturo Carabias

Publikováno v: Nature Communications
Carabias, A, Fuglsang, A, Temperini, P, Pape, T, Sofos, N, Stella, S, Erlendsson, S & Montoya, G 2021, ' Structure of the mini-RNA-guided endonuclease CRISPR-Cas12j3 ', Nature Communications, vol. 12, 4476 . https://doi.org/10.1038/s41467-021-24707-3
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

CRISPR-Cas12j is a recently identified family of miniaturized RNA-guided endonucleases from phages. These ribonucleoproteins provide a compact scaffold gathering all key activities of a genome editing tool. We provide the first structural insight int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::380dfd70481600acb8e2ab65f51df601
http://europepmc.org/articles/PMC8298400

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Transport of Folded Proteins by the Tat System

Autor: Kelly M. Frain, Colin Robinson, Jan Maarten van Dijl

Publikováno v: The Protein Journal

The twin-arginine protein translocation (Tat) system has been characterized in bacteria, archaea and the chloroplast thylakoidal membrane. This system is distinct from other protein transport systems with respect to two key features. Firstly, it acce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e733b98ddb3505541868cd7eb20b3c87
https://doi.org/10.1007/s10930-019-09859-y

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Transport of Folded Proteins by the Tat System

Publikováno v: Protein journal. 38(4):377-388

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___01423::0942a7ecfd48ce90f5d24f1ca6e7e2a1
https://research.rug.nl/en/publications/29643d7e-d23b-47c2-982d-3750686e4fc3

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Direct protein-lipid interactions shape the conformational landscape of secondary transporters

Autor: Mrinal Shekhar, Eamonn Reading, Chloe Martens, Emad Tajkhorshid, Argyris Politis, Antoni J. Borysik, Andy M. Lau, Paula J. Booth

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Martens, C, Shekhar, M, Borysik, A, Lau, A M C, Tajkhorshid, E, Reading, E, Booth, P J & Politis, A 2018, ' Direct protein-lipid interactions shape the conformational landscape of secondary transporters ', Nature Communications, vol. 9, 4151 . https://doi.org/10.1038/s41467-018-06704-1
Nature communications, 9 (1

Secondary transporters undergo structural rearrangements to catalyze substrate translocation across the cell membrane - yet how such conformational changes happen within a lipid environment remains poorly understood. Here, we combine hydrogen-deuteri

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https://doaj.org/article/3878486fe69c4a06a829c58c6f048e54

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Crystal Structure of a ligand-bound LacY–Nanobody Complex

Autor: Irina Smirnova, H. Ronald Kaback, Xiaoxu Jiang, Els Pardon, Robert M. Stroud, Jan Steyaert, Vladimir N. Kasho, Janet Finer-Moore, Hemant Kumar

Publikováno v: Proceedings of the National Academy of Sciences. 115:8769-8774

The lactose permease of Escherichia coli (LacY), a dynamic polytopic membrane transport protein, catalyzes galactoside/H(+) symport and operates by an alternating access mechanism that exhibits multiple conformations, the distribution of which is alt

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https://doi.org/10.1073/pnas.1801774115

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Complete alanine scanning of the Escherichia coli RbsB ribose binding protein reveals residues important for chemoreceptor signaling and periplasmic abundance

Autor: Siham Beggah, Manuel Hernandez Gil, Vitali Maffenbeier, Artur Reimer, Manupriyam Dubey, Vladimir Sentchilo, Diogo Tavares, Jan Roelof van der Meer

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific reports, vol. 7, no. 1, pp. 8245
Scientific Reports

The Escherichia coli RbsB ribose binding protein has been used as a scaffold for predicting new ligand binding functions through in silico modeling, yet with limited success and reproducibility. In order to possibly improve the success of predictive

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https://doaj.org/article/0b1e4619ab914a33b84f04afc5cf2d7e

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The CcmC-CcmE interaction during cytochrome c maturation by System I is driven by protein-protein and not protein-heme contacts

Autor: Shevket, S, Gonzalez, D, Cartwright, J, Kleanthous, C, Ferguson, S, Redfield, C, Mavridou, D

Publikováno v: The Journal of biological chemistry, vol. 293, no. 43, pp. 16778-16790
The Journal of Biological Chemistry

Cytochromes c are ubiquitous proteins, essential for life in most organisms. Their distinctive characteristic is the covalent attachment of heme to their polypeptide chain. This post-translational modification is performed by a dedicated protein syst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f3119cdfd690c5d082899df7d50308ce
http://hdl.handle.net/10044/1/64693

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Structure–Function Analysis of the C-Terminal Domain of the Type VI Secretion TssB Tail Sheath Subunit

Autor: Laureen Logger, Stéphanie Blangy, Badreddine Douzi, Silvia Spinelli, Christian Cambillau, Eric Cascales

Publikováno v: Journal of Molecular Biology
Journal of Molecular Biology, 2018, 430 (3), pp.297-309. ⟨10.1016/j.jmb.2017.11.015⟩
Journal of Molecular Biology, Elsevier, 2018, 430 (3), pp.297-309. ⟨10.1016/j.jmb.2017.11.015⟩

International audience; The type VI secretion system (T6SS) is a specialized macromolecular complex dedicated to the delivery of protein effectors into both eukaryotic and bacterial cells. The general mechanism of action of the T6SS is similar to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e581b7f1c9c27388df743e3261240c5
https://hal-amu.archives-ouvertes.fr/hal-01780748

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The Effect of Detergent, Temperature, and Lipid on the Oligomeric State of MscL Constructs: Insights from Mass Spectrometry

Autor: Idlir Liko, Troy A. Walton, Eamonn Reading, Carol V. Robinson, Arthur Laganowsky, Michael T. Marty, Douglas C. Rees

Publikováno v: Reading, E, Walton, T A, Liko, I, Marty, M T, Laganowsky, A, Rees, D C & Robinson, C V 2015, ' The Effect of Detergent, Temperature, and Lipid on the Oligomeric State of MscL Constructs : Insights from Mass Spectrometry ', Chemistry and Biology, vol. 22, no. 5, pp. 593-603 . https://doi.org/10.1016/j.chembiol.2015.04.016

The mechanosensitive channel of large conductance (MscL) acts as an emergency release valve for osmotic shock of bacteria preventing cell lysis. The large pore size, essential for function, requires the formation of oligomers with tetramers, pentamer

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