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Metabolic RNA labeling in non-engineered cells following spontaneous uptake of fluorescent nucleoside phosphate analogues.

Autor: Pfeiffer P; Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Kemivägen 10, SE-41296 Gothenburg, Sweden., Nilsson JR; Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Kemivägen 10, SE-41296 Gothenburg, Sweden.; LanteRNA (Stealth Labels Biotech AB), c/o Chalmers Ventures AB, Vera Sandbergs allé 8, SE-41296 Gothenburg, Sweden., Gallud A; Department of Life Sciences, Chalmers University of Technology, Kemivägen 10, SE-41296 Gothenburg, Sweden.; Advanced Drug Delivery, Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, SE-43181 Gothenburg, Sweden., Baladi T; Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Kemivägen 10, SE-41296 Gothenburg, Sweden.; Oligonucleotide Discovery, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Le HN; Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Kemivägen 10, SE-41296 Gothenburg, Sweden.; Oligonucleotide Discovery, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Bood M; Oligonucleotide Discovery, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.; Department of Chemistry and Molecular Biology, University of Gothenburg, P.O. Box 462, SE-40530 Gothenburg, Sweden., Lemurell M; Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Dahlén A; Oligonucleotide Discovery, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Grøtli M; Department of Chemistry and Molecular Biology, University of Gothenburg, P.O. Box 462, SE-40530 Gothenburg, Sweden., Esbjörner EK; Department of Life Sciences, Chalmers University of Technology, Kemivägen 10, SE-41296 Gothenburg, Sweden., Wilhelmsson LM; Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Kemivägen 10, SE-41296 Gothenburg, Sweden.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2024 Sep 23; Vol. 52 (17), pp. 10102-10118.

Extracellular Vesicles Slow Down Aβ(1-42) Aggregation by Interfering with the Amyloid Fibril Elongation Step.

Autor: Halipi V; Division of Chemical Biology, Department of Life Sciences, Chalmers University of Technology, Kemivägen 10, S-412 96 Gothenburg, Sweden., Sasanian N; Division of Chemical Biology, Department of Life Sciences, Chalmers University of Technology, Kemivägen 10, S-412 96 Gothenburg, Sweden., Feng J; Division of Chemical Biology, Department of Life Sciences, Chalmers University of Technology, Kemivägen 10, S-412 96 Gothenburg, Sweden., Hu J; Division of Physical Chemistry, Department of Chemistry, Lund University, SE-22100 Lund, Sweden., Lubart Q; Division of Chemical Biology, Department of Life Sciences, Chalmers University of Technology, Kemivägen 10, S-412 96 Gothenburg, Sweden., Bernson D; Division of Chemical Biology, Department of Life Sciences, Chalmers University of Technology, Kemivägen 10, S-412 96 Gothenburg, Sweden., van Leeuwen D; Division of Chemical Biology, Department of Life Sciences, Chalmers University of Technology, Kemivägen 10, S-412 96 Gothenburg, Sweden., Ahmadpour D; Division of Chemical Biology, Department of Life Sciences, Chalmers University of Technology, Kemivägen 10, S-412 96 Gothenburg, Sweden., Sparr E; Division of Physical Chemistry, Department of Chemistry, Lund University, SE-22100 Lund, Sweden., Esbjörner EK; Division of Chemical Biology, Department of Life Sciences, Chalmers University of Technology, Kemivägen 10, S-412 96 Gothenburg, Sweden.

Publikováno v: ACS chemical neuroscience [ACS Chem Neurosci] 2024 Mar 06; Vol. 15 (5), pp. 944-954. Date of Electronic Publication: 2024 Feb 26.

Monovalent cations have different effects on the assembly kinetics and morphology of α-synuclein amyloid fibrils.

Autor: Havemeister F; Division of Chemical Biology, Department of Life Sciences, Chalmers University of Technology, Kemivägen 10, S-41296, Gothenburg, Sweden., Ghaeidamini M; Division of Chemical Biology, Department of Life Sciences, Chalmers University of Technology, Kemivägen 10, S-41296, Gothenburg, Sweden., Esbjörner EK; Division of Chemical Biology, Department of Life Sciences, Chalmers University of Technology, Kemivägen 10, S-41296, Gothenburg, Sweden. Electronic address: eline@chalmers.se.

Publikováno v: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2023 Oct 30; Vol. 679, pp. 31-36. Date of Electronic Publication: 2023 Aug 29.

Interaction Kinetics of Individual mRNA-Containing Lipid Nanoparticles with an Endosomal Membrane Mimic: Dependence on pH, Protein Corona Formation, and Lipoprotein Depletion.

Autor: Aliakbarinodehi N; Division of Nano and Biophysics, Department of Physics, Chalmers University of Technology 41296 Göteborg, Sweden., Gallud A; Division of Chemical Biology, Department of Biology and Biological Engineering, Chalmers University of Technology, 41296 Göteborg, Sweden.; Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, 43181 Gothenburg, Sweden., Mapar M; Division of Nano and Biophysics, Department of Physics, Chalmers University of Technology 41296 Göteborg, Sweden., Wesén E; Division of Chemical Biology, Department of Biology and Biological Engineering, Chalmers University of Technology, 41296 Göteborg, Sweden., Heydari S; Division of Chemical Biology, Department of Biology and Biological Engineering, Chalmers University of Technology, 41296 Göteborg, Sweden., Jing Y; Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, 43181 Gothenburg, Sweden., Emilsson G; Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, 43181 Gothenburg, Sweden., Liu K; Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, 43181 Gothenburg, Sweden., Sabirsh A; Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, 43181 Gothenburg, Sweden., Zhdanov VP; Division of Nano and Biophysics, Department of Physics, Chalmers University of Technology 41296 Göteborg, Sweden.; Boreskov Institute of Catalysis, Russian Academy of Sciences, Novosibirsk 630090, Russia., Lindfors L; Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, 43181 Gothenburg, Sweden., Esbjörner EK; Division of Chemical Biology, Department of Biology and Biological Engineering, Chalmers University of Technology, 41296 Göteborg, Sweden., Höök F; Division of Nano and Biophysics, Department of Physics, Chalmers University of Technology 41296 Göteborg, Sweden.

Publikováno v: ACS nano [ACS Nano] 2022 Dec 27; Vol. 16 (12), pp. 20163-20173. Date of Electronic Publication: 2022 Dec 13.