Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Esbjörn Melin"'
Autor:
Esbjörn Melin, Avtandil Nanobashvili, Una Avdic, Casper R. Gøtzsche, My Andersson, David P.D. Woldbye, Merab Kokaia
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss , Pp 179-193 (2019)
Gene therapy has been suggested as a plausible novel approach to achieve seizure control in patients with focal epilepsy that do not adequately respond to pharmacological treatment. We investigated the seizure-suppressant potential of combinatorial n
Externí odkaz:
https://doaj.org/article/e42ffa9d891a4a0e901825ec3b32a469
Autor:
Julia Alicja Szczygieł, Kira Iben Danielsen, Esbjörn Melin, Søren Hofman Rosenkranz, Stanislava Pankratova, Annika Ericsson, Karin Agerman, Merab Kokaia, David Paul Drucker Woldbye
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Gene therapy to treat pharmacoresistant temporal lobe epilepsy in humans is now being developed using an AAV vector (CG01) that encodes the combination of neuropeptide Y and its antiepileptic receptor Y2. With this in mind, the present study aimed to
Externí odkaz:
https://doaj.org/article/08b2c28562df493993f2e0974d8dbb58
Autor:
Litsa Nikitidou Ledri, Esbjörn Melin, Søren H. Christiansen, Casper R. Gøtzsche, Alessandra Cifra, David P.D. Woldbye, Mérab Kokaia
Publikováno v:
Neurobiology of Disease, Vol 86, Iss , Pp 52-61 (2016)
Although novel treatment strategies based on the gene therapy approach for epilepsy has been encouraging, there is still a gap in demonstrating a proof-of-concept in a clinically relevant animal model and study design. In the present study, a concept
Externí odkaz:
https://doaj.org/article/8ae6219ecdbe40ec88fab64f7aa14751
Autor:
Esbjörn Melin, My Andersson, Casper R. Gøtzsche, Jenny Wickham, Yuzhe Huang, Julia Alicja Szczygiel, Arnie Boender, Søren H. Christiansen, Lars Pinborg, David P. D. Woldbye, Merab Kokaia
Publikováno v:
Gene Therapy.
Gene therapy with AAV vectors carrying genes for neuropeptide Y and its receptor Y2 has been shown to inhibit seizures in multiple animal models of epilepsy. It is however unknown how the AAV serotype or the sequence order of these two transgenes in
Autor:
Lars Wahlberg, Michele Simonato, Merab Kokaia, Dwaine F. Emerich, Esbjörn Melin, Avtandil Nanobashvili, Jens Tornøe
Publikováno v:
Gene Therapy. 26:65-74
Temporal lobe epilepsy (TLE) is the most common type of epilepsy in adults. This neurological disorder is characterized by focal seizures originating in the temporal lobe, often with secondary generalization. A variety of pharmacological treatments e
Autor:
Merab Kokaia, Esbjörn Melin, David P.D. Woldbye, Stanislava Pankratova, Søren Hofman Rosenkranz, Julia Alicja Szczygieł, Karin Agerman, Annika Ericsson, Kira Iben Danielsen
Publikováno v:
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Szczygieł, J A, Danielsen, K I, Melin, E, Rosenkranz, S H, Pankratova, S, Ericsson, A, Agerman, K, Kokaia, M & Woldbye, D P D 2020, ' Gene Therapy Vector Encoding Neuropeptide Y and Its Receptor Y2 for Future Treatment of Epilepsy : Preclinical Data in Rats ', Frontiers in Molecular Neuroscience, vol. 13, 232 . https://doi.org/10.3389/fnmol.2020.603409
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Szczygieł, J A, Danielsen, K I, Melin, E, Rosenkranz, S H, Pankratova, S, Ericsson, A, Agerman, K, Kokaia, M & Woldbye, D P D 2020, ' Gene Therapy Vector Encoding Neuropeptide Y and Its Receptor Y2 for Future Treatment of Epilepsy : Preclinical Data in Rats ', Frontiers in Molecular Neuroscience, vol. 13, 232 . https://doi.org/10.3389/fnmol.2020.603409
Gene therapy to treat pharmacoresistant temporal lobe epilepsy in humans is now being developed using an AAV vector (CG01) that encodes the combination of neuropeptide Y and its antiepileptic receptor Y2. With this in mind, the present study aimed to
Autor:
Anu Lipsanen, Wolfgang Löscher, Olli Gröhn, Albert J. Becker, Teresa Ravizza, Michele Simonato, Niina Lapinlampi, Jan A. Gorter, Merab Kokaia, Jussi Paananen, Asla Pitkänen, Cristophe Bernard, Eleonora Aronica, Jens P. Bankstahl, Esbjörn Melin, Annamaria Vezzani, Paolo Roncon, Katarzyna Lukasiuk
Publikováno v:
Epilepsy Research, 129, 87-90. Elsevier
Epilepsy Research
Epilepsy Research, Elsevier, 2017, 129, pp.87-90. ⟨10.1016/j.eplepsyres.2016.11.010⟩
Epilepsy research, 129, 87-90. Elsevier
Epilepsy Research
Epilepsy Research, Elsevier, 2017, 129, pp.87-90. ⟨10.1016/j.eplepsyres.2016.11.010⟩
Epilepsy research, 129, 87-90. Elsevier
Article
Lack of translation of data obtained in preclinical trials to clinic has kindled researchers to develop new methodologies to increase the power and reproducibility of preclinical studies. One approach relates to harmonization of data col
Lack of translation of data obtained in preclinical trials to clinic has kindled researchers to develop new methodologies to increase the power and reproducibility of preclinical studies. One approach relates to harmonization of data col
Autor:
David P.D. Woldbye, Merab Kokaia, Esbjörn Melin, Litsa Nikitidou Ledri, Casper René Gøtzsche, Alessandra Cifra, Søren H. Christiansen
Publikováno v:
Neurobiology of Disease, Vol 86, Iss, Pp 52-61 (2016)
Although novel treatment strategies based on the gene therapy approach for epilepsy has been encouraging, there is still a gap in demonstrating a proof-of-concept in a clinically relevant animal model and study design. In the present study, a concept
Autor:
Esbjörn Melin
Publikováno v:
Lund University
Lund University, Faculty of Medicine Doctoral Dissertation Series; (2020:24) (2020)
Lund University, Faculty of Medicine Doctoral Dissertation Series; (2020:24) (2020)
Epilepsy is a neurological disorder, affecting approximately 1% of the population. The high rate of drug-resistance in epilepsy in general (30%), and temporal lobe epilepsy (TLE) in particular, pose a serious clinical problem. Thus, novel treatments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::01b2b4b28a351a269cd339e64cf5aa99
https://portal.research.lu.se/en/publications/a50f666a-8950-474b-ad0d-50225c0f555d
https://portal.research.lu.se/en/publications/a50f666a-8950-474b-ad0d-50225c0f555d