Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Esben S Sørensen"'
Autor:
Stacyann Bailey, Grazyna E Sroga, Betty Hoac, Orestis L Katsamenis, Zehai Wang, Nikolaos Bouropoulos, Marc D McKee, Esben S Sørensen, Philipp J Thurner, Deepak Vashishth
Publikováno v:
eLife, Vol 9 (2020)
Protein phosphorylation, critical for cellular regulatory mechanisms, is implicated in various diseases. However, it remains unknown whether heterogeneity in phosphorylation of key structural proteins alters tissue integrity and organ function. Here,
Externí odkaz:
https://doaj.org/article/93fc932c9bd84bb49dd5fb7d47765f13
Autor:
Brian Christensen, Gitte N Schytte, Carsten Scavenius, Jan J Enghild, Marc D McKee, Esben S Sørensen
Publikováno v:
JBMR Plus, Vol 4, Iss 8, Pp n/a-n/a (2020)
ABSTRACT Matrix extracellular phosphoglycoprotein (MEPE) is expressed in bone and teeth where it has multiple functions. The C‐terminus of MEPE contains a mineral‐binding, acidic serine‐ and aspartate‐rich motif (ASARM) that is also present i
Externí odkaz:
https://doaj.org/article/e20ebaf5192043908ab233ad33899d50
Autor:
Brian Christensen, Elias D Zachariae, Carsten Scavenius, Morten Thybo, Morten M Callesen, Søren Kløverpris, Claus Oxvig, Jan J Enghild, Esben S Sørensen
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e113650 (2014)
Osteopontin (OPN) is a highly posttranslationally modified protein present in several tissues where it is implicated in numerous physiological processes. OPN primarily exerts its functions through interaction with integrins via the Arg-Gly-Asp and Se
Externí odkaz:
https://doaj.org/article/91eb4cf627154237952b16409d3c23c7
Autor:
Stephen A. Fleming, Sarah M. Reyes, Sharon M. Donovan, Olle Hernell, Rulan Jiang, Bo Lönnerdal, Josef Neu, Lawrence Steinman, Esben S. Sørensen, Christina E. West, Ronald Kleinman, John C. Wallingford
Publikováno v:
Frontiers in Nutrition, Vol 11 (2024)
Human milk, due to its unique composition, is the optimal standard for infant nutrition. Osteopontin (OPN) is abundant in human milk but not bovine milk. The addition of bovine milk osteopontin (bmOPN) to formula may replicate OPN’s concentration a
Externí odkaz:
https://doaj.org/article/eed2ae986a36498689796d737fbbeba8
Autor:
Esben S. Sørensen, Brian Christensen
Publikováno v:
Sørensen, E S & Christensen, B 2023, ' Milk Osteopontin and Human Health ', Nutrients, vol. 15, no. 11, 2423 . https://doi.org/10.3390/nu15112423
Osteopontin (OPN) is a multifunctional protein found in all vertebrates. OPN is expressed in many different cell types, and is consequently found in most tissues and physiological secretions. OPN is involved in a multitude of biological processes, su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca480d12695a6c560df6261e9cff183
https://pure.au.dk/portal/da/publications/milk-osteopontin-and-human-health(8f307001-1277-4c7c-ade0-15e03bbd08aa).html
https://pure.au.dk/portal/da/publications/milk-osteopontin-and-human-health(8f307001-1277-4c7c-ade0-15e03bbd08aa).html
Autor:
Brian Christensen, Albert J. Buitenhuis, Lotte N. Jacobsen, Marie S. Ostenfeld, Esben S. Sørensen
Publikováno v:
Nutrients
Volume 15
Issue 5
Pages: 1166
Christensen, B, Buitenhuis, A J, Jacobsen, L N, Ostenfeld, M S & Sørensen, E S 2023, ' The Effect of Human and Bovine Milk Osteopontin on Intestinal Caco-2 Cells : A Transcriptome Comparison ', Nutrients, vol. 15, no. 5, 1166 . https://doi.org/10.3390/nu15051166
Volume 15
Issue 5
Pages: 1166
Christensen, B, Buitenhuis, A J, Jacobsen, L N, Ostenfeld, M S & Sørensen, E S 2023, ' The Effect of Human and Bovine Milk Osteopontin on Intestinal Caco-2 Cells : A Transcriptome Comparison ', Nutrients, vol. 15, no. 5, 1166 . https://doi.org/10.3390/nu15051166
Osteopontin (OPN) is a multifunctional protein abundantly present in human milk, whereas the concentration is significantly lower in bovine milk. Human and bovine milk OPN are structurally similar and both proteins resist gastric digestion and reach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e860cc2c2609178515f9c87e213a6968
Autor:
Esben S. Sørensen, Grum Gebreyesus, Bart Buitenhuis, Lotte Bach Larsen, Christian W. Heegaard, Mette Krogh Larsen, Nina Aagaard Poulsen
Publikováno v:
Gebreyesus, G, Poulsen, N A, Larsen, M K, Larsen, L B, Sørensen, E S, Würtz Heegaard, C & Buitenhuis, A J 2021, ' Vitamin B12 and transcobalamin in bovine milk : Genetic variation and genome-wide association with loci along the genome ', JDS Communications, vol. 2, no. 3, pp. 127-131 . https://doi.org/10.3168/jdsc.2020-0048
In human nutrition, bovine milk is an essential source of bioavailable vitamin B12 and B12-binding proteins, including transcobalamin. In this study, we estimated genetic parameters for milk content of vitamin B12 and transcobalamin using milk sample
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eb1376b9f1daee284348f3f4ad6b7fd
https://doi.org/10.3168/jdsc.2020-0048
https://doi.org/10.3168/jdsc.2020-0048
Autor:
Brian Christensen, Nanna R. Nielsen, Marie R. Sørensen, Lotte N. Jacobsen, Marie S. Ostenfeld, Esben S. Sørensen
Publikováno v:
Christensen, B, Nielsen, N R, Sørensen, M R, Jacobsen, L N, Ostenfeld, M S & Sørensen, E S 2023, ' Naturally Occurring N-Terminal Fragments of Bovine Milk Osteopontin Are Transported across Models of the Intestinal Barrier ', Biomedicines, vol. 11, no. 3 . https://doi.org/10.3390/biomedicines11030893
Biomedicines; Volume 11; Issue 3; Pages: 893
Biomedicines; Volume 11; Issue 3; Pages: 893
Osteopontin (OPN) is a bioactive integrin-binding protein found in high concentrations in milk, where it is present both as a full-length protein and as several N-terminally derived fragments. OPN resists gastric digestion, and via interaction with r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::805371bd91eb0c3c09a44a29ad1e1341
https://doi.org/10.3390/biomedicines11030893
https://doi.org/10.3390/biomedicines11030893
Autor:
Jan J. Enghild, Esben S. Sørensen, Ida Bregenov, Carsten Scavenius, Gitte N Schytte, Katarzyna Kjøge, Brian Christensen, Steen V. Petersen
Publikováno v:
Schytte, G N, Christensen, B, Bregenov, I, Kjøge, K, Scavenius, C, Petersen, S V, Enghild, J J & Sørensen, E S 2020, ' FAM20C phosphorylation of the RGDSVVYGLR motif in osteopontin inhibits interaction with the αvβ3 integrin ', Journal of Cellular Biochemistry, vol. 121, no. 12, pp. 4809-4818 . https://doi.org/10.1002/jcb.29708
Osteopontin (OPN) is a ubiquitously expressed, multifunctional, and highly phosphorylated protein. OPN contains two neighboring integrin-binding motifs, RGD and SVVYGLR, which mediate interaction with cells. Phosphorylation and proteolytic processing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e2a04a8dfddfc1e7221fa3cc9022d0
https://doi.org/10.1002/jcb.29708
https://doi.org/10.1002/jcb.29708
Autor:
Lotte Bach Larsen, Esben S. Sørensen, Elias D. Zachariae, Albert Johannes Buitenhuis, Brian Christensen, Nina Aagaard Poulsen
Publikováno v:
Christensen, B, Zachariae, E D, Poulsen, N A, Buitenhuis, A J, Larsen, L B & Sørensen, E S 2021, ' Factors influencing milk osteopontin concentration based on measurements from Danish Holstein cows ', Journal of Dairy Research, vol. 88, no. 1, pp. 89-94 . https://doi.org/10.1017/S0022029921000054
Our objective was to determine the content of the bioactive protein osteopontin (OPN) in bovine milk and identify factors influencing its concentration. OPN is expressed in many tissues and body fluids, with by far the highest concentrations in milk.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c539a432935095dbd84a4ea6a3b72c9b
https://pure.au.dk/portal/da/publications/factors-influencing-milk-osteopontin-concentration-based-on-measurements-from-danish-holstein-cows(cc3da1af-971b-4d6a-83fb-7e8e2db8b873).html
https://pure.au.dk/portal/da/publications/factors-influencing-milk-osteopontin-concentration-based-on-measurements-from-danish-holstein-cows(cc3da1af-971b-4d6a-83fb-7e8e2db8b873).html