Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Esben B. Svenningsen"'
Autor:
Naziia Kurmasheva, Aida Said, Boaz Wong, Priscilla Kinderman, Xiaoying Han, Anna H. F. Rahimic, Alena Kress, Madalina E. Carter-Timofte, Emilia Holm, Demi van der Horst, Christoph F. Kollmann, Zhenlong Liu, Chen Wang, Huy-Dung Hoang, Elina Kovalenko, Maria Chrysopoulou, Krishna Sundar Twayana, Rasmus N. Ottosen, Esben B. Svenningsen, Fabio Begnini, Anders E. Kiib, Florian E. H. Kromm, Hauke J. Weiss, Daniele Di Carlo, Michela Muscolini, Maureen Higgins, Mirte van der Heijden, Angelina Bardoul, Tong Tong, Attila Ozsvar, Wen-Hsien Hou, Vivien R. Schack, Christian K. Holm, Yunan Zheng, Melanie Ruzek, Joanna Kalucka, Laureano de la Vega, Walid A. M. Elgaher, Anders R. Korshoej, Rongtuan Lin, John Hiscott, Thomas B. Poulsen, Luke A. O’Neill, Dominic G. Roy, Markus M. Rinschen, Nadine van Montfoort, Jean-Simon Diallo, Henner F. Farin, Tommy Alain, David Olagnier
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-28 (2024)
Abstract The presence of heterogeneity in responses to oncolytic virotherapy poses a barrier to clinical effectiveness, as resistance to this treatment can occur through the inhibition of viral spread within the tumor, potentially leading to treatmen
Externí odkaz:
https://doaj.org/article/cf343351f5cf4766ad351ee93729ee99
Autor:
Laura Casares, Rita Moreno, Kevin X. Ali, Maureen Higgins, Sharadha Dayalan Naidu, Graham Neill, Lena Cassin, Anders E. Kiib, Esben B. Svenningsen, Alberto Minassi, Tadashi Honda, Thomas B. Poulsen, Clotilde Wiel, Volkan I. Sayin, Albena T. Dinkova-Kostova, David Olagnier, Laureano de la Vega
Publikováno v:
Redox Biology, Vol 51, Iss , Pp 102291- (2022)
The transcription factor BACH1 is a potential therapeutic target for a variety of chronic conditions linked to oxidative stress and inflammation, as well as cancer metastasis. However, only a few BACH1 degraders/inhibitors have been described. BACH1
Externí odkaz:
https://doaj.org/article/1416ed819aa4406aaf232a9276b3919d
Autor:
David Olagnier, Ensieh Farahani, Jacob Thyrsted, Julia Blay-Cadanet, Angela Herengt, Manja Idorn, Alon Hait, Bruno Hernaez, Alice Knudsen, Marie Beck Iversen, Mirjam Schilling, Sofie E. Jørgensen, Michelle Thomsen, Line S. Reinert, Michael Lappe, Huy-Dung Hoang, Victoria H. Gilchrist, Anne Louise Hansen, Rasmus Ottosen, Camilla G. Nielsen, Charlotte Møller, Demi van der Horst, Suraj Peri, Siddharth Balachandran, Jinrong Huang, Martin Jakobsen, Esben B. Svenningsen, Thomas B. Poulsen, Lydia Bartsch, Anne L. Thielke, Yonglun Luo, Tommy Alain, Jan Rehwinkel, Antonio Alcamí, John Hiscott, Trine H. Mogensen, Søren R. Paludan, Christian K. Holm
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Viral infections usually cause disease through direct cytopathogenic effects and excessive inflammatory responses. Here, Olagnier et al. show that two NRF2 agonists, 4-OI and DMF, possess broad IFN-independent antiviral activity and decrease host inf
Externí odkaz:
https://doaj.org/article/7eb1ed3741cc4fbfa366937b0037cc35
Autor:
David Olagnier, Ensieh Farahani, Jacob Thyrsted, Julia Blay-Cadanet, Angela Herengt, Manja Idorn, Alon Hait, Bruno Hernaez, Alice Knudsen, Marie Beck Iversen, Mirjam Schilling, Sofie E. Jørgensen, Michelle Thomsen, Line S. Reinert, Michael Lappe, Huy-Dung Hoang, Victoria H. Gilchrist, Anne Louise Hansen, Rasmus Ottosen, Camilla G. Nielsen, Charlotte Møller, Demi van der Horst, Suraj Peri, Siddharth Balachandran, Jinrong Huang, Martin Jakobsen, Esben B. Svenningsen, Thomas B. Poulsen, Lydia Bartsch, Anne L. Thielke, Yonglun Luo, Tommy Alain, Jan Rehwinkel, Antonio Alcamí, John Hiscott, Trine H. Mogensen, Søren R. Paludan, Christian K. Holm
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/7a767ab0a50943a0a5a6e85eaa10ccfe
Autor:
Alejandro Mahía, Anders E. Kiib, Marija Nisavic, Esben B. Svenningsen, Johan Palmfeldt, Thomas B. Poulsen
Publikováno v:
Angewandte Chemie International Edition.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616fc190b86ecf5b7f2aa0b8e3ddff50
https://doi.org/10.1002/anie.202304142
https://doi.org/10.1002/anie.202304142
Autor:
Esben B. Svenningsen, Rasmus N. Ottosen, Katrine H. Jørgensen, Marija Nisavic, Camilla K. Larsen, Bente K. Hansen, Yong Wang, Kresten Lindorff-Larsen, Thomas Tørring, Stephan M. Hacker, Johan Palmfeldt, Thomas B. Poulsen
Publikováno v:
Svenningsen, E B, Ottosen, R N, Jørgensen, K H, Nisavic, M, Larsen, C K, Hansen, B K, Wang, Y, Lindorff-Larsen, K, Tørring, T, Hacker, S M, Palmfeldt, J & Poulsen, T B 2022, ' The covalent reactivity of functionalized 5-hydroxy-butyrolactams is the basis for targeting of fatty acid binding protein 5 (FABP5) by the neurotrophic agent MT-21 ', RSC Chemical Biology, vol. 3, no. 10, pp. 1216-1229 . https://doi.org/10.1039/d2cb00161f
RSC Chemical Biology, 3(10), 1216-1229. ROYAL SOC CHEMISTRY
RSC Chemical Biology, 3(10), 1216-1229. ROYAL SOC CHEMISTRY
Covalently acting compounds experience a strong interest within chemical biology both as molecular probes in studies of fundamental biological mechanisms and/or as novel drug candidates. In this context, the identification of new classes of reactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a351c21acb8ea1a8fe4082e4a7f639
https://doi.org/10.1039/d2cb00161f
https://doi.org/10.1039/d2cb00161f
Autor:
Kira Jennet, Rasmus Ottosen, Esben B. Svenningsen, Martin R. Jakobsen, Thomas B. Poulsen, Mette Biltoft, Han Liu, Tobias Kristensen
Publikováno v:
Liu, H, Ottosen, R N, Jennet, K M, Svenningsen, E B, Kristensen, T F, Biltoft, M, Jakobsen, M R & Poulsen, T B 2021, ' Macrodiolide Diversification Reveals Broad Immunosuppressive Activity That Impairs the cGAS-STING Pathway ', Angewandte Chemie International Edition, vol. 60, no. 34, pp. 18734-18741 . https://doi.org/10.1002/anie.202105793
The development of new immunomodulatory agents can impact various areas of medicine. In particular, compounds with the ability to modulate innate immunological pathways hold significant unexplored potential. Here, we report a modular synthetic approa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3ca8f41f306be39d52b8b22123c2ca
https://doi.org/10.1002/anie.202105793
https://doi.org/10.1002/anie.202105793
Autor:
Thomas Tørring, Jaime Moyano-Villameriel, Malene Wollesen, Thomas B. Poulsen, Christine N. Pedersen, Frederikke D. Andersen, Han Liu, Kristian M. Jacobsen, Peter Nørby, Shaoquan Lin, Esben B. Svenningsen
Publikováno v:
Nature Chemistry
Nature chemistry
Lin, S, Liu, H, Svenningsen, E B, Wollesen, M, Jacobsen, K M, Andersen, F D, Moyano-Villameriel, J, Pedersen, C N, Nørby, P, Tørring, T & Poulsen, T B 2021, ' Expanding the antibacterial selectivity of polyether ionophore antibiotics through diversity-focused semisynthesis ', Nature Chemistry, vol. 13, no. 1, pp. 47-55 . https://doi.org/10.1038/s41557-020-00601-1
Nature chemistry
Lin, S, Liu, H, Svenningsen, E B, Wollesen, M, Jacobsen, K M, Andersen, F D, Moyano-Villameriel, J, Pedersen, C N, Nørby, P, Tørring, T & Poulsen, T B 2021, ' Expanding the antibacterial selectivity of polyether ionophore antibiotics through diversity-focused semisynthesis ', Nature Chemistry, vol. 13, no. 1, pp. 47-55 . https://doi.org/10.1038/s41557-020-00601-1
Polyether ionophores are complex natural products capable of transporting cations across biological membranes. Many polyether ionophores possess potent antimicrobial activity and a few selected compounds have the ability to target aggressive cancer c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95445becf1000d7092cfae4f7e688d01
https://doi.org/10.1038/s41557-020-00601-1
https://doi.org/10.1038/s41557-020-00601-1
Autor:
Christian K. Holm, Anne L. Thielke, Rasmus Ottosen, Thomas B. Poulsen, Jinrong Huang, Alice Knudsen, Lydia Bartsch, Siddharth Balachandran, Marie B. Iversen, Camilla G. Nielsen, Victoria H. Gilchrist, Trine H. Mogensen, Huy-Dung Hoang, Alon Schneider Hait, Sofie E. Jørgensen, Line S. Reinert, Suraj Peri, Jan Rehwinkel, Michael Lappe, Charlotte Möller, Michelle M. Thomsen, John Hiscott, Demi van der Horst, Esben B. Svenningsen, Anne Louise Hansen, Yonglun Luo, Jacob Thyrsted, Manja Idorn, Antonio Alcami, Ensieh Farahani, Julia Blay-Cadanet, Martin R. Jakobsen, Bruno Hernáez, Mirjam Schilling, David Olagnier, Søren R. Paludan, Angela Herengt, Tommy Alain
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Olagnier, D, Farahani, E, Thyrsted, J, Blay-Cadanet, J, Herengt, A, Idorn, M, Hait, A, Hernaez, B, Knudsen, A, Iversen, M B, Schilling, M, Jørgensen, S E, Thomsen, M, Reinert, L S, Lappe, M, Hoang, H-D, Gilchrist, V H, Hansen, A L, Ottosen, R, Nielsen, C G, Møller, C, van der Horst, D, Peri, S, Balachandran, S, Huang, J, Jakobsen, M, Svenningsen, E B, Poulsen, T B, Bartsch, L, Thielke, A L, Luo, Y, Alain, T, Rehwinkel, J, Alcamí, A, Hiscott, J, Mogensen, T H, Paludan, S R & Holm, C K 2020, ' SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate ', Nature Communications, vol. 11, no. 1, 4938 . https://doi.org/10.1038/s41467-020-18764-3
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Olagnier, D P C, Farahani, E, Jensen, J T, Blay Cadanet, J, Herengt, A A P V, Idorn, M, Schneider Hait, A I, Hernaez, B, Knudsen, A, Iversen, M B, Schilling, M, Jørgensen, S E, Thomsen, M M, Reinert, L S, Lappe, M, Hoang, H D, Gilchrist, V H, Hansen, A L, Ottosen, R, Nielsen, C G, Møller, C, van der Horst, D, Peri, S, Balachandran, S, Huang, J, Jakobsen, M, Svenningsen, E B, Poulsen, T B, Bartsch, L, Thielke, A L, Luo, Y, Alain, T, Rehwinkel, J, Alcamí, A, Hiscott, J, Mogensen, T H, Paludan, S R & Holm, C K 2020, ' SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate ', Nature Communications, vol. 11, 4938 . https://doi.org/10.1038/s41467-020-18764-3
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Olagnier, D, Farahani, E, Thyrsted, J, Blay-Cadanet, J, Herengt, A, Idorn, M, Hait, A, Hernaez, B, Knudsen, A, Iversen, M B, Schilling, M, Jørgensen, S E, Thomsen, M, Reinert, L S, Lappe, M, Hoang, H-D, Gilchrist, V H, Hansen, A L, Ottosen, R, Nielsen, C G, Møller, C, van der Horst, D, Peri, S, Balachandran, S, Huang, J, Jakobsen, M, Svenningsen, E B, Poulsen, T B, Bartsch, L, Thielke, A L, Luo, Y, Alain, T, Rehwinkel, J, Alcamí, A, Hiscott, J, Mogensen, T H, Paludan, S R & Holm, C K 2020, ' SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate ', Nature Communications, vol. 11, no. 1, 4938 . https://doi.org/10.1038/s41467-020-18764-3
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Olagnier, D P C, Farahani, E, Jensen, J T, Blay Cadanet, J, Herengt, A A P V, Idorn, M, Schneider Hait, A I, Hernaez, B, Knudsen, A, Iversen, M B, Schilling, M, Jørgensen, S E, Thomsen, M M, Reinert, L S, Lappe, M, Hoang, H D, Gilchrist, V H, Hansen, A L, Ottosen, R, Nielsen, C G, Møller, C, van der Horst, D, Peri, S, Balachandran, S, Huang, J, Jakobsen, M, Svenningsen, E B, Poulsen, T B, Bartsch, L, Thielke, A L, Luo, Y, Alain, T, Rehwinkel, J, Alcamí, A, Hiscott, J, Mogensen, T H, Paludan, S R & Holm, C K 2020, ' SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate ', Nature Communications, vol. 11, 4938 . https://doi.org/10.1038/s41467-020-18764-3
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Versiones preprint disponibles en: http://hdl.handle.net/10261/216920 y http://hdl.handle.net/10261/217161
Antiviral strategies to inhibit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and the pathogenic consequences of COVID-19 ar
Antiviral strategies to inhibit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and the pathogenic consequences of COVID-19 ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c770a0f99e983608245ee2ef5c88b25
https://doaj.org/article/7eb1ed3741cc4fbfa366937b0037cc35
https://doaj.org/article/7eb1ed3741cc4fbfa366937b0037cc35
Autor:
Esben B. Svenningsen, Joseph A. Izzo, Yidong Liu, Thomas B. Poulsen, Karl Anker Jørgensen, David McLeod, Sebastijan Ričko
Publikováno v:
Liu, Y, Izzo, J A, McLeod, D, Ričko, S, Svenningsen, E B, Poulsen, T B & Jørgensen, K A 2021, ' Organocatalytic Asymmetric Multicomponent Cascade Reaction for the Synthesis of Contiguously Substituted Tetrahydronaphthols ', Journal of the American Chemical Society, vol. 143, no. 21, pp. 8208-8220 . https://doi.org/10.1021/jacs.1c03923
Isobenzopyrylium ions are unique, highly reactive, aromatic intermediates which are largely unexplored in asymmetric catalysis despite their high potential synthetic utility. In this study, an organocatalytic asymmetric multicomponent cascade via die
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5972c46c1a1855dbe5bdff5e3b5addd0
https://pure.au.dk/portal/da/publications/organocatalytic-asymmetric-multicomponent-cascade-reaction-for-the-synthesis-of-contiguously-substituted-tetrahydronaphthols(6c721c34-4e08-47fb-a325-ae907c10d0bb).html
https://pure.au.dk/portal/da/publications/organocatalytic-asymmetric-multicomponent-cascade-reaction-for-the-synthesis-of-contiguously-substituted-tetrahydronaphthols(6c721c34-4e08-47fb-a325-ae907c10d0bb).html
