Phase II study of uPAR-PET/CT for staging of primary breast cancer in comparison with ultrasound and fine needle biopsies

Autor: Marie Øbro Fosbøl, Esben Andreas Carlsen, Malene Brandt-Larsen, Camilla Christensen, Jacob Madsen, Annika Loft, Anne Kiil Berthelsen, Tove Filtenborg Tvedskov, Niels Kroman, Kim Francis Andersen, Eric von Benzon, Andreas Kjaer

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)

Abstract Accurate initial staging of patients with breast cancer is essential for planning optimal treatment strategies. However, currently, no imaging modality is able to detect lymph node metastases preoperatively with sufficient reliability; there

Externí odkaz: https://doaj.org/article/0403cac26f5a41279c942547b0fd3aae

A convolutional neural network for total tumor segmentation in [64Cu]Cu-DOTATATE PET/CT of patients with neuroendocrine neoplasms

Autor: Esben Andreas Carlsen, Kristian Lindholm, Amalie Hindsholm, Mathias Gæde, Claes Nøhr Ladefoged, Mathias Loft, Camilla Bardram Johnbeck, Seppo Wang Langer, Peter Oturai, Ulrich Knigge, Andreas Kjaer, Flemming Littrup Andersen

Publikováno v: EJNMMI Research, Vol 12, Iss 1, Pp 1-10 (2022)

Abstract Background Segmentation of neuroendocrine neoplasms (NENs) in [64Cu]Cu-DOTATATE positron emission tomography makes it possible to extract quantitative measures useable for prognostication of patients. However, manual tumor segmentation is cu

Externí odkaz: https://doaj.org/article/eeb514d8235f486b8e309f1663897bd7

Prospective Phase II Trial of [68Ga]Ga-NODAGA-E[c(RGDyK)]2PET/CT Imaging of Integrin αvβ3for Prognostication in Patients with Neuroendocrine Neoplasms

Autor: Esben Andreas Carlsen, Mathias Loft, Annika Loft, Dorota Czyzewska, Mikkel Andreassen, Seppo W. Langer, Ulrich Knigge, Andreas Kjaer

Publikováno v: Journal of Nuclear Medicine. 64:252-259

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73a098362b6180fff6f06becf6b27c88
https://doi.org/10.2967/jnumed.122.264383

Prospective Phase II Trial of Prognostication by (68)Ga-NOTA-AE105 uPAR PET in Patients with Neuroendocrine Neoplasms: Implications for uPAR-Targeted Therapy

Autor: Esben Andreas Carlsen, Mathias Loft, Annika Loft, Anne Kiil Berthelsen, Seppo W. Langer, Ulrich Knigge, Andreas Kjaer

Publikováno v: J Nucl Med
Carlsen, E A, Loft, M, Loft, A, Berthelsen, A K, Langer, S W, Knigge, U & Kjaer, A 2022, ' Prospective phase II trial of prognostication by 68Ga-NOTA-AE105 uPAR PET in patients with neuroendocrine neoplasms: Implications for uPAR targeted therapy ', Journal of Nuclear Medicine, vol. 63, no. 9, pp. 1371-1377 . https://doi.org/10.2967/jnumed.121.263177

The clinical course for patients with neuroendocrine neoplasms (NENs) ranges from indolent to highly aggressive. Noninvasive tools to improve prognostication and guide decisions on treatment are warranted. Expression of urokinase plasminogen activato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6deb2377261c2df148ea296215d2e74
https://europepmc.org/articles/PMC9454472/

64Cu-DOTATATE PET in Patients with Neuroendocrine Neoplasms: Prospective, Head-to-Head Comparison of Imaging at 1 Hour and 3 Hours After Injection

Autor: Esben Andreas Carlsen, Annika Loft, Helle Hjorth Johannesen, Tina Binderup, Andreas Klaus Pfeifer, Seppo W. Langer, Jann Mortensen, Ulrich Knigge, Anne Kiil Berthelsen, Mathias Loft, Peter Oturai, Camilla Bardram Johnbeck, Andreas Kjaer

Publikováno v: Loft, M, Carlsen, E A, Johnbeck, C B, Johannesen, H H, Binderup, T, Pfeifer, A, Mortensen, J, Oturai, P, Loft, A, Berthelsen, A K, Langer, S W, Knigge, U & Kjaer, A 2021, ' 64 Cu-DOTATATE PET in Patients with Neuroendocrine Neoplasms : Prospective, Head-to-Head Comparison of Imaging at 1 Hour and 3 Hours Post-Injection ', The Journal of Nuclear Medicine, vol. 62, no. 1, pp. 73-80 . https://doi.org/10.2967/jnumed.120.244509

64Cu-DOTATATE PET/CT imaging 1 hour (h) post-injection (p.i.) is excellent for lesion detection in patients with neuroendocrine neoplasms (NEN). We hypothesized that the imaging time window can be extended up to 3h p.i. without significant difference

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab391305cb05e4aca110c9a3d9610a4
https://doi.org/10.2967/jnumed.120.244509