Synthesis, antitumour and antioxidant activities of novel α,β-unsaturated ketones and related heterocyclic analogues: EGFR inhibition and molecular modelling study

Autor: Walaa M. El-Husseiny, Magda A.-A. El-Sayed, Naglaa I. Abdel-Aziz, Adel S. El-Azab, Esam R. Ahmed, Alaa A.-M. Abdel-Aziz

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 507-518 (2018)

New α,β-unsaturated ketones 4a,b; 5a–c; and 6a,b; as well as 4-H pyran 7; pyrazoline 8a,b; isoxazoline 9; pyridine 10–11; and quinoline-4-carboxylic acid 12a,b derivatives were synthesized and evaluated for in vitro antitumour activity against

Externí odkaz: https://doaj.org/article/ffe7cb284bb742a5b8b4fb2fc4452d4a

Targeted anticancer potential against glioma cells of thymoquinone delivered by mesoporous silica core-shell nanoformulations with pH-dependent release

Autor: Iman M Higazy, Ahmed M. Aboul-Enein, Witold Lojkowski, Samar A Shahein, Esam R Ahmed, Khaled AbouAitah, Shaker A. Mousa, Faten Abou-Elella

Publikováno v: International Journal of Nanomedicine

Samar A Shahein1,*Ahmed M Aboul-Enein,1 Iman M Higazy,2 Faten Abou-Elella,1 Witold Lojkowski,3 Esam R Ahmed,4 Shaker A Mousa,5 Khaled AbouAitah3,6,*1Biochemistry Department, Faculty of Agriculture, Cairo University, Giza, Egypt; 2Department of Pharma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a454a51edcd22b3b532c6caaa212e00
http://europepmc.org/articles/PMC6650459

Synthesis and biological evaluation of novel 5-chloro-N-(4-sulfamoylbenzyl) salicylamide derivatives as tubulin polymerization inhibitors

Autor: Maha M. Soltan, Alaaeldin M. F. Galal, Atef G Hanna, Esam R. Ahmed

Publikováno v: MedChemComm. 9:1511-1528

A novel series of sulfonamide derivatives, coupled with a salicylamide scaffold, was designed and synthesized. The structures of the synthesized compounds were established using 1H NMR, 13C NMR and high-resolution mass spectroscopy. The synthesized c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df075f4c8e6ba6e0f06ea164eafeffd1
https://doi.org/10.1039/c8md00214b

Synthesis and biological evaluation of novel 5-chloro

Autor: Alaaeldin M F, Galal, Maha M, Soltan, Esam R, Ahmed, Atef G, Hanna

Publikováno v: MedChemComm. 9(9)

A novel series of sulfonamide derivatives, coupled with a salicylamide scaffold, was designed and synthesized. The structures of the synthesized compounds were established using (1)H NMR, (13)C NMR and high-resolution mass spectroscopy. The synthesiz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::00d95ff899f640953c660ad2a8cc2336
https://pubmed.ncbi.nlm.nih.gov/30288225

Synthesis, antitumour and antioxidant activities of novel α,β-unsaturated ketones and related heterocyclic analogues: EGFR inhibition and molecular modelling study

Autor: Magda A.-A. El-Sayed, Esam R. Ahmed, Walaa M. El-Husseiny, Alaa A.-M. Abdel-Aziz, Adel S. El-Azab, Naglaa I. Abdel-Aziz

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 507-518 (2018)
Journal of Enzyme Inhibition and Medicinal Chemistry

New α,β-unsaturated ketones 4a,b; 5a–c; and 6a,b; as well as 4-H pyran 7; pyrazoline 8a,b; isoxazoline 9; pyridine 10–11; and quinoline-4-carboxylic acid 12a,b derivatives were synthesized and evaluated for in vitro antitumour activity against

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f110d3e3c5d1aef30e2e7d9928c64ea