Zobrazeno 1 - 10
of 290
pro vyhledávání: '"Esa R Korpi"'
Autor:
Elina Nagaeva, Ivan Zubarev, Carolina Bengtsson Gonzales, Mikko Forss, Kasra Nikouei, Elena de Miguel, Lauri Elsilä, Anni-Maija Linden, Jens Hjerling-Leffler, George J Augustine, Esa R Korpi
Publikováno v:
eLife, Vol 9 (2020)
The cellular architecture of the ventral tegmental area (VTA), the main hub of the brain reward system, remains only partially characterized. To extend the characterization to inhibitory neurons, we have identified three distinct subtypes of somatost
Externí odkaz:
https://doaj.org/article/52b46d9c58a14a8587f7ac245893a9d1
Autor:
Elli Leppä, Anni-Maija Tuulikki Linden, M. Isabel Aller, Peer Wulff, Olga Vekovischeva, Bernhard Lüscher, Hartmut Lüddens, William Wisden, Esa R Korpi
Publikováno v:
Frontiers in Pharmacology, Vol 7 (2016)
Endogenous neurosteroids and neuroactive steroids have potent and widespread actions on the brain via inhibitory GABAA receptors. In recombinant receptors and genetic mouse models their actions depend on the alpha, beta and delta subunits of the rece
Externí odkaz:
https://doaj.org/article/99d976fd8ef64a769f0f9c05c1069500
Autor:
Amol K Bhandage, Zhe eJin, Igor eBazov, Olga eKononenko, Georgy eBakalkin, Esa R Korpi, Bryndis eBirnir
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 8 (2014)
Chronic consumption of alcohol by humans has been shown to lead to impairment of executive and cognitive functions. Here we have studied the changes that take place in the dorsal striatum in post-mortem brains of alcoholics and normal controls. The r
Externí odkaz:
https://doaj.org/article/82baab181dc14f52879d3039963fd8c2
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
GABAA receptors are the main fast inhibitory neurotransmitter receptors in the mammalian brain, and targets for many clinically important drugs widely used in the treatment of anxiety disorders, insomnia and in anesthesia. Nonetheless, there are sign
Externí odkaz:
https://doaj.org/article/00f58f6a9f9447098401fd3c9f43b6a6
Autor:
Zhe eJin, Amol K Bhandage, Igor eBazov, Olga eKononenko, Georgy eBakalkin, Esa R Korpi, Bryndis eBirnir
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 8 (2014)
The central nucleus of amygdala (CeA) has a role for mediating fear and anxiety responses. It is also involved in emotional imbalance caused by alcohol abuse and dependence and in regulating relapse to alcohol abuse. Growing evidences suggest that ex
Externí odkaz:
https://doaj.org/article/60a7fec3b6f74ae99ea18a6eb4f86c43
Autor:
Zhe eJin, Amol K Bhandage, Igor eBazov, Olga eKononenko, Georgy eBakalkin, Esa R Korpi, Bryndis eBirnir
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 8 (2014)
Glutamate is the main excitatory transmitter in the human brain. Drugs that affect the glutamatergic signaling will alter neuronal excitability. Ethanol inhibits glutamate receptors. We examined the expression level of glutamate receptor subunit mRNA
Externí odkaz:
https://doaj.org/article/31a6d92704654587953b8f7c60eb536b
Autor:
Tarja Joensuu, Saara Tegelberg, Eva Reinmaa, Mikael Segerstråle, Paula Hakala, Heidi Pehkonen, Esa R Korpi, Jaana Tyynelä, Tomi Taira, Iiris Hovatta, Outi Kopra, Anna-Elina Lehesjoki
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89321 (2014)
Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) is an autosomal recessively inherited neurodegenerative disease, manifesting with myoclonus, seizures and ataxia, caused by mutations in the cystatin B (CSTB) gene. With the aim of und
Externí odkaz:
https://doaj.org/article/efbc09911f944d31a65931d0f21924a6
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100188 (2014)
Abnormal excitatory glutamate neurotransmission and plasticity have been implicated in schizophrenia and affective disorders. Gria1-/- mice lacking GluA1 subunit (encoded by Gria1 gene) of AMPA-type glutamate receptor show robust novelty-induced hype
Externí odkaz:
https://doaj.org/article/8bbbce973a994f088f4ae5ff86f5ec67
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49282 (2012)
Agonist responses and channel kinetics of native α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are modulated by transmembrane accessory proteins. Stargazin, the prototypical accessory protein, decreases desensitization and i
Externí odkaz:
https://doaj.org/article/46e64062634d4e2b994e7b1fa046bb16
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 5 (2012)
Alcohol dependence is a common chronic relapsing disorder. The development of alcohol dependence has been associated with changes in brain GABA-A channel-mediated neurotransmission and plasticity. We have examined mRNA expression of the GABA-A channe
Externí odkaz:
https://doaj.org/article/67ea01a62e054a5494abe3dec4a7bc44