Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Esa Laurila"'
Autor:
Anke Tönjes, Markus Scholz, Jana Breitfeld, Carola Marzi, Harald Grallert, Arnd Gross, Claes Ladenvall, Dorit Schleinitz, Kerstin Krause, Holger Kirsten, Esa Laurila, Jennifer Kriebel, Barbara Thorand, Wolfgang Rathmann, Leif Groop, Inga Prokopenko, Bo Isomaa, Frank Beutner, Jürgen Kratzsch, Joachim Thiery, Mathias Fasshauer, Nora Klöting, Christian Gieger, Matthias Blüher, Michael Stumvoll, Peter Kovacs
Publikováno v:
PLoS Genetics, Vol 10, Iss 12, p e1004854 (2014)
Chemerin is an adipokine proposed to link obesity and chronic inflammation of adipose tissue. Genetic factors determining chemerin release from adipose tissue are yet unknown. We conducted a meta-analysis of genome-wide association studies (GWAS) for
Externí odkaz:
https://doaj.org/article/d91331cb0317497aaef3f0b855299ac6
Autor:
Ola Ekström, Kristoffer Ström, Bilal Ahmad Mir, Esa Laurila, Ylva Wessman, Mikko Lehtovirta, Karl‐Fredrik Eriksson, Ola Hansson
Publikováno v:
Clinical Physiology and Functional Imaging.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46c07baedaf5446a35ddf1bb558b3f0a
https://doi.org/10.1111/cpf.12816
https://doi.org/10.1111/cpf.12816
Autor:
Wolfgang Rathmann, Knut Krohn, Antje Fischer-Rosinsky, Peter Kovacs, Joachim Spranger, Jürgen Kratzsch, Christian Gieger, Frank Beutner, Bo Isomaa, Carola Marzi, Jennifer Kriebel, Christa Meisinger, Claes Ladenvall, Claudia Gebhardt, Anke Tönjes, Henrike O. Heyne, Andreas Pfeiffer, Dorit Schleinitz, Leif Groop, Jacqueline Krüger, Michael Stumvoll, Joachim Thiery, Inga Prokopenko, Matthias Blüher, Kerstin Krause, Markus Scholz, Esa Laurila, Harald Grallert, Holger Kirsten
Publikováno v:
Hum. Mol. Genet. 27, 546-558 (2018)
© The Author(s) 2017. Published by Oxford University Press. All rights reserved. Progranulin is a secreted protein with important functions in processes including immune and inflammatory response, metabolism and embryonic development. The present st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d179a78672470c9b5efc1c9fbd049bab
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=52913
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=52913
Autor:
Andreas Lindqvist, Olof Asplund, Emma Ahlqvist, Esa Laurila, Nils Wierup, Tiinamaija Tuomi, Peter Almgren, Jens J. Holst, Emily Sonestedt, Marju Orho-Melander, Ulrika Krus, Leif Groop, Peter M. Nilsson, Liisa Hakaste, Emilia Ottosson-Laakso, Rashmi B. Prasad, Olle Melander
Publikováno v:
Almgren, P, Lindqvist, A, Krus, U, Hakaste, L, Ottosson-Laakso, E, Asplund, O, Sonestedt, E, Prasad, R B, Laurila, E, Orho-Melander, M, Melander, O, Tuomi, T, Holst, J J, Nilsson, P M, Wierup, N, Groop, L & Ahlqvist, E 2017, ' Genetic determinants of circulating GIP and GLP-1 concentrations ', JCI insight, vol. 2, no. 21, e93306 . https://doi.org/10.1172/jci.insight.93306
The secretion of insulin and glucagon from the pancreas and the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) from the gastrointestinal tract is essential for glucose homeostasis. Several novel t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9730492c0d028350d4ca7aab1fcb81
https://doi.org/10.1172/jci.insight.93306
https://doi.org/10.1172/jci.insight.93306
Autor:
David Altshuler, Martin Ridderstråle, Leif Groop, Pablo Tamayo, Jill P. Mesirov, Esa Laurila, Mark J. Daly, Emma Carlsson, J. Lehar, Cecilia M. Lindgren, Aravind Subramanian, Vamsi K. Mootha, Joel N. Hirschhorn, Todd R. Golub, Eric S. Lander, Nick Patterson, Nicholas E. Houstis, Pere Puigserver, Bruce M. Spiegelman, Smita Sihag, Karl-Fredrik Eriksson
DNA microarrays can be used to identify gene expression changes characteristic of human disease. This is challenging, however, when relevant differences are subtle at the level of individual genes. We introduce an analytical strategy, Gene Set Enrich
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012104c453c569e4d2b36feff17a14c3
https://doi.org/10.1038/ng1180
https://doi.org/10.1038/ng1180
Autor:
Esa Laurila, Pasi K. Korhonen, Virve M. Lundgren, Leif Groop, Valeriya Lyssenko, Tiinamaija Tuomi, Bo Isomaa
Publikováno v:
Diabetes
OBJECTIVE To evaluate the significance of GAD antibodies (GADAs) and family history for type 1 diabetes (FHT1) or type 2 diabetes (FHT2) in nondiabetic subjects. RESEARCH DESIGN AND METHODS GADAs were analyzed in 4,976 nondiabetic relatives of type 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e40db3c1e40afc42470a05b2963d5b42
https://doi.org/10.2337/db09-0747
https://doi.org/10.2337/db09-0747
Publikováno v:
European Journal of Endocrinology. :701-707
OBJECTIVE: Insulin resistance is a frequent consequence of GH replacement therapy but patients on GH replacement therapy often also have replacement of other hormone deficiencies which theoretically could modify the metabolic effects of GH. In partic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4589026f3cdb88a6cc33622a97c9fd7
https://doi.org/10.1530/eje.0.1510701
https://doi.org/10.1530/eje.0.1510701
Publikováno v:
Metabolism. 52:535-539
To examine whether the effects of high-fat feeding on glycogen synthase (GS) activity and mRNA levels differ between diabetes-prone (C57BL/6J) and diabetes-resistant mice (NMRI), we measured GS activity and mRNA levels in muscle from C57BL/6J and NMR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5674a5d95e0d4a12a441b1948b308205
https://doi.org/10.1053/meta.2003.50107
https://doi.org/10.1053/meta.2003.50107
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 88:1455-1463
The effects of GH replacement therapy on energy metabolism are still uncertain, and long-term benefits of increased muscle mass are thought to outweigh short-term negative metabolic effects. This study was designed to address this issue by examining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f36164a369a87e59387ce2969d8761
https://doi.org/10.1210/jc.2002-020542
https://doi.org/10.1210/jc.2002-020542
Autor:
Esa Laurila, Jana Breitfeld, Peter Kovacs, Nora Klöting, Barbara Thorand, Harald Grallert, Christian Gieger, Michael Stumvoll, Frank Beutner, Inga Prokopenko, Matthias Blüher, Mathias Fasshauer, Holger Kirsten, Wolfgang Rathmann, Joachim Thiery, Kerstin Krause, Markus Scholz, Dorit Schleinitz, Carola Marzi, Anke Tönjes, Arnd Gross, Leif Groop, Jennifer Kriebel, Jürgen Kratzsch, Claes Ladenvall, Bo Isomaa
Publikováno v:
PLoS Genetics, Vol 10, Iss 12, p e1004854 (2014)
PLoS Genetics
e1004854
PLoS Genet. 10:e1004854 (2015)
PLoS Genetics; 10(12), no e1004854 (2014)
PLoS Genetics
e1004854
PLoS Genet. 10:e1004854 (2015)
PLoS Genetics; 10(12), no e1004854 (2014)
Chemerin is an adipokine proposed to link obesity and chronic inflammation of adipose tissue. Genetic factors determining chemerin release from adipose tissue are yet unknown. We conducted a meta-analysis of genome-wide association studies (GWAS) for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3854e44ade49a8825a531c88353a3ddd
http://europepmc.org/articles/PMC4270463?pdf=render
http://europepmc.org/articles/PMC4270463?pdf=render