Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Erzsebet Borok"'
Autor:
Tamas L. Horvath, David H. Rowitch, Vien Nguyen, Beata Jablonska, Joseph Scafidi, Vittorio Gallo, Flora M. Vaccarino, Adan Aguirre, Erzsebet Borok
Publikováno v:
The Journal of Neuroscience. 32:14775-14793
Diffuse white matter injury (DWMI) caused by hypoxia is associated with permanent neurodevelopmental disabilities in preterm infants. The cellular and molecular mechanisms producing DWMI are poorly defined. Using a mouse model of neonatal hypoxia, we
Autor:
Diego Perez-Tilve, Péter Sótonyi, Beatrix Sarman, Sabrina Diano, Cristina García-Cáceres, Paul T. Pfluger, Barry E. Levin, Julie A. Chowen, Jesús Argente, Matthias H. Tschöp, Marya Shanabrough, Michael A. Cowley, Tamas L. Horvath, Erzsebet Borok, Pablo J. Enriori, Hella S. Brönneke
Publikováno v:
Proceedings of the National Academy of Sciences. 107:14875-14880
The neuronal circuits involved in the regulation of feeding behavior and energy expenditure are soft-wired, reflecting the relative activity of the postsynaptic neuronal system, including the anorexigenic proopiomelanocortin (POMC)-expressing cells o
Autor:
Marya Shanabrough, Hua V. Lin, Hiraku Ono, Tamas L. Horvath, Leona Plum, Erzsebet Borok, Luciano Rossetti, Roger Gutierrez-Juarez, Domenico Accili
Publikováno v:
Diabetes
OBJECTIVE The sites of insulin action in the central nervous system that regulate glucose metabolism and energy expenditure are incompletely characterized. We have shown that mice with hypothalamic deficiency (L1) of insulin receptors (InsRs) fail to
Autor:
Steven G. Kohama, Tamas L. Horvath, Marya Shanabrough, Jodi L. Downs, Erzsebet Borok, Michael R. Dunn, Henryk F. Urbanski
Publikováno v:
Neurobiology of Aging. 28:1286-1295
Orexin neuropeptides regulate arousal state and excite the noradrenergic locus coeruleus (LC), so it is plausible that an age-related loss of orexin neurons and projections to the LC contributes to poor sleep quality in elderly humans and nonhuman pr
Autor:
John D. Elsworth, Mark W. Sleeman, Matthias H. Tschöp, Marya Shanabrough, Alfonso Abizaid, Robert H. Roth, Zane B. Andrews, Erzsebet Borok, Zhong-Wu Liu, Tamas L. Horvath, Xiao-Bing Gao, Marina R. Picciotto
Publikováno v:
Journal of Clinical Investigation. 116:3229-3239
The gut hormone ghrelin targets the brain to promote food intake and adiposity. The ghrelin receptor growth hormone secretagogue 1 receptor (GHSR) is present in hypothalamic centers controlling energy metabolism as well as in the ventral tegmental ar
Autor:
Gregory M. Sutton, Kathleen G. Mountjoy, Michael A. Cowley, Joel K. Elmquist, Zoë D. Thornton-Jones, Jeffrey M. Zigman, Nina Balthasar, Peter G. Clifton, Chen-Yu Zhang, Andrew A. Butler, Ligang Zhou, Jeffrey M. Friedman, Toshiro Kishi, Jia Yu, Charlotte E. Lee, Erzsebet Borok, Olivier Boss, Tamas L. Horvath, Carl J. Aschkenasi, Bradford B. Lowell, Lora K. Heisler, Erin E Jobst, Hongyan Liu
Publikováno v:
Monash University
SummaryThe neural pathways through which central serotonergic systems regulate food intake and body weight remain to be fully elucidated. We report that serotonin, via action at serotonin1B receptors (5-HT1BRs), modulates the endogenous release of bo
Publikováno v:
Neuron. 44(4):677-690
Long-term maintenance and modification of synaptic strength involve the turnover of neurotransmitter receptors. Glutamate receptors are constitutively and acutely internalized, presumptively through clathrin-mediated receptor endocytosis. Here, we sh
Autor:
Genevieve H. Flanders, Elly Nedivi, Tadahiro Fujino, Jennifer H. Leslie, Erzsebet Borok, Tamas L. Horvath, Ronen Eavri, Jerry L. Chen, Walter C. Lin
Publikováno v:
PMC
Use-dependent selection of optimal connections is a key feature of neural circuit development and, in the mature brain, underlies functional adaptation, such as is required for learning and memory. Activity patterns guide circuit refinement through s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c84fe7de6c64cd1a74c3fbd9f580b21d
https://orcid.org/0000-0002-1710-0767
https://orcid.org/0000-0002-1710-0767
Autor:
Qian Gao, Sabrina Diano, Gan Geliang, Catiele Antunes, Zhong-Wu Liu, Yongzhan Nie, Allison W. Xu, Erzsebet Borok, Tamas L. Horvath, Xiao-Bing Gao, Marcelo O. Dietrich, Diogo O. Souza
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(35)
Sirt1 has been associated with various effects of calorie restriction, including an increase in lifespan. Here we show in mice that a central regulatory component in energy metabolism, the hypothalamic melanocortin system, is affected by Sirt1, which
Autor:
Deborah J. Clegg, Erzsebet Borok, Tamas L. Horvath, Jinling Zhu, Ofer Reizes, Qiao Zheng, Stephen C. Benoit, Marya Shanabrough
Publikováno v:
Neuroscience. 171(4)
Obesity is associated with increased risk of diabetes, cardiovascular disease and several types of cancers. The hypothalamus is a region of the brain critical in the regulation of body weight. One of the critical and best studied hypothalamic circuit